ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

4.1.11.5 Effect of TCDD on the antioxidants in the caput, corpus and cauda
epididymides
Administration of TCDD caused significant decrease in the levels of
reduced glutathione and a-tocopherol in the caput, corpus and cauda regions of the
epididymis of the treated rats with respect to the corresponding groups of control
animals (Table 15).
4.1.11.6 Effect of TCDD on the antioxidant enzymes and lipid peroxidation in
the cnput, corpus and caudaepididymides
The activity of superoxide dismutase, catalase, glutathione reductase and
glutathione peroxidase decreased significantly in the caput, corpus and cauda regions
of the epididymis of the treated rats as compared to the corresponding groups of
control animals (Table 16a, 16b & 16c). The level of lipid peroxidation increased
significantly in all the regions of the epididymis of the treated rats as compared to the
corresponding groups of control animals (Table 16a. 16b & 16c).
4.1.12 Effect of TCDD on the levels of reactive oxygen species production,
antioxidants, antioxidant enzymes and lipid peroxidation of kidney
Administration of TCDD at the dose of 1 and 10 ngl Kg body weight did not
cause any significant change in the levels of superoxide anion, nitric oxide. hydrogen
peroxide, glutathione, a-tocopherol, superoxide dismutase. catalase. glutathione
reductase, glutathione peroxidase and lipid peroxidation as compared to the
corresponding groups of control animals (Table 17a to 17c) while administration of
TCDD at the dose of 100 ngl Kg body we~ght caused significant increase in the
production of superoxide anion. nitric oxide. hydrogen peroxidu and
lipid
peroxidation and decreased in the levels of' antioxidant system in the kidney as
compared to the corresponding groups of co~itrol animals (Table 17a to 17c).