ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

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June NHPM, Jansen R, Grootegoed JA, Rommerts FFG, Clausen OPF, van der Molen HJ. Regulation of survival of rat pachytene spermatogenesis by lactate supply 6um Sertoli cells. 1 Reprod Fcrtil 1982; 65: 431438. June NHPM. Jansen R, Grootegoed JA, Rommerts FFC, van der Molen HJ. FSH stimulation of the producuon of yruvate and lactate by rat Senoli cells may be involved in hormonal regulation ofbpermatogenesis. J Reprod Fenil 1983; 68: 219-226. Kamatb SA, Narnyan KA. Interaction of ca2' with endoplasmic reticulum of rat liver. Anal Biochem 1972; 48: 53-61. Knneto M. Kanamori S. Hisbia A, Kishi K. EvididYmal swrrn motion as a parameter of male reproductive toxicity: s@rm -motion, fertility, and histopathology in ethinylesuadiol-treated rats. Reprod Toxicol 1999; 13' 279- 289. Kessopoulou E, Tomlinson MJ, Barran CLR Origin of reactive oxygen spccles in human semen. spermatozoa or leukocytes? J Reprod Fenil 1992; 94: 463-470 Khera KS, Ruddick JA Polychlorinated dibenzo-p-dioxins: perinatal effects and the dominant letbal test in Wistar rats. In: Blair EH (eds.). Chlorodioxins- Origin and Fate. Washington DC: American Chemical Society; 1973: 70-84. Kirchhoff C, Ostcrhoff C, Pcra I, Schr6ter S. Function of human epididymal proteins in sperm maturation. Andrologia 1998; 30: 225-232. Klinefeltcr GR, Has RA. Toxicology of the male excurrent ducts and accessory sex glands. In: Korach KS (eds.). Reproductive Developmental Toxicology. New York: Marcel, Dekkar Inc; 1998: 553- 591. Kochakian CD. Regulation of kidney growth by androgens. In: Uriggs MIL, Christic GA (eds.). Advances in Steroid Biochemistry and pharmacology. London: Academic Press; 1977: 1-34. Kociba FU. Keeler PA, Park CN, Cehring PJ. 2.3.7.8-Tetrachlorodibenw-pdioxin (TCDD): results of a 13 week oral toxicity study in rats. Toxicol Appl Pharmacol 1976; 35: 553-574. Koppenol W, Moreno J, Pryor W, Ischiropoulos H, Beckman JS. Chem Res Toxicol 1992; 5: 834-842. Krishna MC, Russo A, Mitchell JB, Goldstein S, Dafni H, Samuri A. Do nitroxide antioxidants act as scavengers of superoxide or as superoxide disrnutase mimics? J Biol Chem 19%; 27 1 : 260262603 1. Kumar TR, Wan Y, Lu N, Makuk MM. Follicle stimulating hormone is required for ovarian fofficle maturation but not in male fertility. Nar Gent. 1997; 15: 201- 204. Lalchoumyclndane C, Matbur PP. Effect of methoxychlor on the antioxidant system in mitochondria1 and microsome-rich fractions of rat testis. Toxicology 2002; (in press). Latchoumycandane C, Chitra KC, Mathur PP. The effect of methoxychlor on the epididymal antioxidant system in adult rats. Reprod Toxicol2002a; 16: 161 -1 72.
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FUNCTIONAL STUDIES ON THE EFFECTS O
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ACKNOWLEDGEMENTS I wish to express
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TABLE OF CONTENTS Page No ACKNOWLED
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TABLE OF CONTENTS (Continued) Deter
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TABLE OF CONTENTS (Continued) Effec
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TAULIC OF CON'I'ISN'I'S (C'untinued
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xi LIST OF TABLES (Continued) I'agc
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Table 24a Table 24b Table 24c Table
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Fig. 1 Fig. 2 Effect of TCDD on the
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Fig. 12c Fig. 12d Fig. 13 Fig. 14a
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LIST OF FIGURES (Continued) Fig. 23
Page 23 and 24:
LH M PL mg mRNA N AD NADH NADP NADP
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layers, an outer layer of visceral
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tubular epithelium and continually
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lmn~unization of monkeys against FS
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and this reaction is catalyzed by t
Page 33 and 34:
extratubular environment or synthes
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the most active in protein secretio
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1958). A rapid fall in serum testos
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have also been reported in the rats
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Effect of TCDD on heart muscle has
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1.4 Effect of oxidative stress on m
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2 SCOPE OF THE PRESENT STUDY There
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3 MATERIALS AND METHODS 3.1 Animals
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Subgroup III: Administration of TCD
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choppcd with the help of sharp razo
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anti-FSH antibody. After incubation
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lust sped (500 to 700 rpm) on an or
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3.13.4 Quantitative determinntiun u
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The plates were dried by inverting
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centrifuged at 3,500 g for I5 min o
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3.17 Preparation of tiasue humogena
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supcrnutant was taken. Hlunk was pr
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3.21.4 Assay of glutathione peroxid
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4 RESULTS 4.1 Administration of TCD
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seminiferous tubules was found to b
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fractions of rat testis as compared
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4.1.11.1 Effect of TCDD on the prod
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4.2 Co-administration of TCDD and v
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4.2.8 Effect of co-administration o
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4.2.11.5 Effect of co-administratio
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Table I b. Effect of TCDD on the we
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Table 4. Effect of TCDD on the seru
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Table 7b. Effect of TCDD on the pro
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Table 8c. Effect of TCDD on the lev
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Table 9d. Effect of TCDD on the act
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Table 13. Effect of TCDD on the ant
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Table 15. Effect of TCDD on the lev
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Table 16c. Effcct of TCDD on the an
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Table 18a. Effect of co-administrat
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Table 21. Effect of co-administrati
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Table 24b. Effect of co-administrat
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Table 25c. Effect of co-administrat
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Table 26d. Effect of co-administrat
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Table 30. Effect of co-administrati
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Table 32. Effect of caadrninistrati
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Table 33c. Effcct of co-administrut
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5 DISCUSSION 5.1 Significance of th
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Measurement of weights of the acces
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compartment of the cells (Chainy el
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the reduction in daily sperm produc
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eported in the TCDD-treated rats (M
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lilnction is to ililcrccpt lipid pc
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in the animals administered with TC
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protective effects on serum testost
Page 133: suygcstccl that vivamin 1: conld im
Page 136 and 137: Fig.4~. ENect of TCDD or TCDD and v
Page 138: tE W d In w it I I (,OCX) 3s PUB (,
Page 142 and 143: Fig. 7c. Effect of TCDD or TCDD and
Page 145 and 146: u 3 f ~ = m w * N O .- ~Slew aew en
Page 147 and 148: Fig.lOb. ENmt of TCDD or TCDD and v
Page 151: Fig. 1Ir Effect of TCDD or TCDD md
Page 158 and 159: Fig. 14c. Effect of TCDD or TCDD an
Page 160 and 161: Fig. 16b. Effect of TCDD or TCDD an
Page 164 and 165: Fig.18~. EKect of TCDD or TCDD and
Page 166 and 167: 1 1.2 l4 Fig. 19b. ENect of TCDD or
Page 168 and 169: Fig. ZOb. Elkt of TCDD or TCDD and
Page 171 and 172: Fig. 21. Effect olTCDD or TCDD and
Page 173 and 174: Fig. 22c. Effect of TCDD or TCDD an
Page 175 and 176: Fig. 24b. Eflect ofTCDD or TCDD and
Page 177 and 178: 7 REFERENCES Aitken RJ, Irvine DS,
Page 179 and 180: Chitm KC, Latchoumycandanc,C, Mathu
Page 181 and 182: Flsher JS, Turner KJ, Brown D, Shar
Page 183: Hornsby PJ. Regulation of cytochrom
Page 187 and 188: Moore RW, Panona JA, Bookstaff RC,
Page 189 and 190: Rommerts FFG, Cooke BA, Van Der Kem
Page 191 and 192: Slaunwhite WR, Burgett MJ. h virro
Page 193 and 194: 1.1 Preparation of dosing solution
Page 195 and 196: 1.4.6 Wash concentrate One bottle,
Page 197 and 198: 1.7.3 Estradiol controls Two vials.
Page 199 and 200: 1.1 1.2 Orcinol(6%) 6 g of orcinol
Page 201 and 202: 1.16.2 Horseradish peroxidase (8 Un
Page 203 and 204: 1.20 Superoxide dismutase 1.20.1 Tr
Page 205 and 206: 1.24.2 Thiobarbituric acid (TBA; 0.
Page 207 and 208: Chronic effect: of enclosulfan on t
Page 209: enbw1h1.W mu IUY Wcab unpiliml~t at
Page 212 and 213: cbniuis 11~11 b"nci:~lc ~wlive oxyg
Page 214 and 215: DNA, RNA ;uxl Wcin wcrr abarval, wh
Page 216 and 217: Mt~~m(10-lZsu&)vacob- Wfmn Ihehml ~
Page 218 and 219: New Delhi, llrliil Ib SCI~KK Rcm& M
Page 220 and 221: tiii~lc rcprmluction or rut (Cllitr
Page 222 and 223: wciglit (b.wt.) per day for 45 days
Page 224 and 225: 0.1 00 01 " 0.8 I . .lo Dl* rcnn IW
Page 226 and 227: Chilr:~. K.C.. L!olnn!myci!~dum. C.
Page 228 and 229: C. hteboumyeradlos . KC. CMtn . P.P
Page 230 and 231: I. 1 Ilal 01 2 1.7 # I c I ~ ~ L I
Page 232 and 233: Fin. L Corrclatwn bclwfcn "perm cou
Page 235:
Iionshii nepmdvctivc mxicity ad upt
Page 240 and 241:
o. Glutathione reductage mg pmWn mg
Page 242 and 243:
IOWAME -. Tor. #558517 PME: 9 SESS:
Page 244 and 245:
JOBNAME: Rqm. Tm. M5W7 PAOB: 11 SBS
Page 246 and 247:
t 02 ELSEVIER Toricology OM) (2W1)
Page 248 and 249:
---- - wcre obtu~ncd from E-Monk. G
Page 250:
3.2. A,III~AILNI syrlo~t of ,nIroch
Page 253 and 254:
Uc,#!dy. SC. N;tdcru. S , 1% Conlrb
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