ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

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Chilr:~. K.C.. L!olnn!myci!~dum. C.. Milhur. P.P.. IWP. Kimbroufi. R.D.. 1914. The loaklty d the p+l~Io+.~cd ('l~io~tk cN~yl ol'e~dtaulhn un Ik Inlicukr funstions or imlmciic m d s m d chffabla. CRC Crit. ra A'iiiln J Adrol 1. 203-206 Rn. Toriwl. L 443-498. Chtlr;~. K.C.. Sul;!lha. R.. Lulchoun~yclnJan. C.. Mathur. Klirrkksr. 0.1, Heo, I.&, 1998, To* 01 lhc male P 1'. XKll, EGXI rf lindme nn entinxid.nl ctuymn in uarmnt d m ad r4 *.dl. In: Kod. K.s. cpal*ly~nir >~tmI r~t'dym~l sprm of ntlull mu. Asinn J (Ed.). R*nodustk and R*okmul Toikdqy, pp. Andt,-l J. ?(I5 XIR. -((1. -- 0- . 1 , ('littlwrn~.,\.. lVX5. 11,. C~RVIIWI~!~. R. (W.1. IlmJhr,k Kono. V. FtlJa!ch. I.. IPU. Supmxidc ndbl inhibits Mrlln
S.tlc. S.. ?IXII. Mubuli~r bioluyy ol 1 l ,411 ~ rwqvlut iwd it* IOIC Sl1n11h.S l .Alrlt.~c~l.N.J .Sh;tr;!. M,A..Al~ll,~y:tl~./. A,. Wi!ltl?.t. in ath'iaop~xsis. 'Turir'ol. Lull. 120. 1-7. Z.Z., IWI. Bvidmwr. tor IIIC it~duclioa ol ill! ox3;clive sllcrr Slliarp. R.M.. 1993. Oxlining rprlll ~ounlr in mcn - i: ll>elu is rut hcp;nlcmilwh~ndria by 2.3.1.8~MIrucl~l~~rodibE1~~~~1~. "a cdwrinc ruur'? I, lidwrinui. 116. 317. Jbll. dtoxin fTCI)I)). Ad", lirp. MIYI. Ricll. 2x1, &?I R3l Silwl. I1.M.. tirrlrr. I'.. I1)XI. i~~wliv~~lk~~~ a%( 11111111111 ('11 /.!I SIIFIII.II:I. K.. Kilt~~l,l~ti~. S . Yiu~tl~d:~. I .. l )Itlit. S.. )liw1:~\liil,8, r~~~ur~~r~Jiaa~~luwduri~\lsr~~u~Llt~O~~~~JII~O,~ Arch. K., YI~su~I~, M.~ lri~,i~i.Kt~riy:,~tt;t, Y,, 21811 Aryl lhycl~twa~. II~x.ln~t. Ilu!pl~y. 212. 41-1 4Ib. Skme, S.A.. Lkwltunl. IS.. (imcnhry. M.. 1989. I'oiyel!lu!i. IIUIL~ dibnus.(#-dit)ai8ih atd polychbrinul~d rlikwh,. lur~l rvruelar IAIIW I.,t!etli;llcd l~alt!eli~n~t,l xi~~~ll~i~lc ~ull~l:)~.f x;~t~lllilludcl~ydru&~~!i~~-;~~livily by !.~.~.R.IcI~~~cI~~~~II~II~II , I'untn.: Ilr rill 10 bulnna hullll, A Rcv. Ilunl. 'l'ari~r,l 8. llrr). 177 ?lIJ. huj;ellt;t. H..Cltllr;t. LC.. I.i~lul~~nt~~~yvi~lId:~l,c.C.. M,llll\rr, I'.I' . S~ohx. SJ.. IW. O~idulive atw induced by 2.3.7.8-lclrd. ?WI. E ~ of ltndsm I on Icsicubr rnl~o~iJa,lr syrlcln und chloralibmw.pdwxi~~ ITCDU). Fra Rud. Biol. Mcd. 9. 79-W. aerotdoscnic cnzymn in adult ruts. Astun J. Androl. 3. 135-138.
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FUNCTIONAL STUDIES ON THE EFFECTS O
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ACKNOWLEDGEMENTS I wish to express
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TABLE OF CONTENTS Page No ACKNOWLED
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TABLE OF CONTENTS (Continued) Deter
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TABLE OF CONTENTS (Continued) Effec
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TAULIC OF CON'I'ISN'I'S (C'untinued
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xi LIST OF TABLES (Continued) I'agc
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Table 24a Table 24b Table 24c Table
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Fig. 1 Fig. 2 Effect of TCDD on the
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Fig. 12c Fig. 12d Fig. 13 Fig. 14a
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LIST OF FIGURES (Continued) Fig. 23
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LH M PL mg mRNA N AD NADH NADP NADP
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layers, an outer layer of visceral
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tubular epithelium and continually
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lmn~unization of monkeys against FS
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and this reaction is catalyzed by t
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extratubular environment or synthes
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the most active in protein secretio
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1958). A rapid fall in serum testos
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have also been reported in the rats
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Effect of TCDD on heart muscle has
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1.4 Effect of oxidative stress on m
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2 SCOPE OF THE PRESENT STUDY There
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3 MATERIALS AND METHODS 3.1 Animals
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Subgroup III: Administration of TCD
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choppcd with the help of sharp razo
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anti-FSH antibody. After incubation
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lust sped (500 to 700 rpm) on an or
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3.13.4 Quantitative determinntiun u
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The plates were dried by inverting
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centrifuged at 3,500 g for I5 min o
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3.17 Preparation of tiasue humogena
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supcrnutant was taken. Hlunk was pr
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3.21.4 Assay of glutathione peroxid
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4 RESULTS 4.1 Administration of TCD
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seminiferous tubules was found to b
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fractions of rat testis as compared
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4.1.11.1 Effect of TCDD on the prod
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4.2 Co-administration of TCDD and v
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4.2.8 Effect of co-administration o
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4.2.11.5 Effect of co-administratio
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Table I b. Effect of TCDD on the we
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Table 4. Effect of TCDD on the seru
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Table 7b. Effect of TCDD on the pro
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Table 8c. Effect of TCDD on the lev
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Table 9d. Effect of TCDD on the act
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Table 13. Effect of TCDD on the ant
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Table 15. Effect of TCDD on the lev
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Table 16c. Effcct of TCDD on the an
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Table 18a. Effect of co-administrat
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Table 21. Effect of co-administrati
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Table 24b. Effect of co-administrat
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Table 25c. Effect of co-administrat
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Table 26d. Effect of co-administrat
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Table 30. Effect of co-administrati
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Table 32. Effect of caadrninistrati
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Table 33c. Effcct of co-administrut
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5 DISCUSSION 5.1 Significance of th
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Measurement of weights of the acces
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compartment of the cells (Chainy el
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the reduction in daily sperm produc
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eported in the TCDD-treated rats (M
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lilnction is to ililcrccpt lipid pc
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in the animals administered with TC
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protective effects on serum testost
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suygcstccl that vivamin 1: conld im
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Fig.4~. ENect of TCDD or TCDD and v
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tE W d In w it I I (,OCX) 3s PUB (,
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Fig. 7c. Effect of TCDD or TCDD and
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u 3 f ~ = m w * N O .- ~Slew aew en
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Fig.lOb. ENmt of TCDD or TCDD and v
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Fig. 1Ir Effect of TCDD or TCDD md
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Fig. 14c. Effect of TCDD or TCDD an
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Fig. 16b. Effect of TCDD or TCDD an
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Fig.18~. EKect of TCDD or TCDD and
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1 1.2 l4 Fig. 19b. ENect of TCDD or
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Fig. ZOb. Elkt of TCDD or TCDD and
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Fig. 21. Effect olTCDD or TCDD and
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Fig. 22c. Effect of TCDD or TCDD an
Page 175 and 176: Fig. 24b. Eflect ofTCDD or TCDD and
Page 177 and 178: 7 REFERENCES Aitken RJ, Irvine DS,
Page 179 and 180: Chitm KC, Latchoumycandanc,C, Mathu
Page 181 and 182: Flsher JS, Turner KJ, Brown D, Shar
Page 183 and 184: Hornsby PJ. Regulation of cytochrom
Page 185 and 186: Latcboumycandane C, Chitra KC, Math
Page 187 and 188: Moore RW, Panona JA, Bookstaff RC,
Page 189 and 190: Rommerts FFG, Cooke BA, Van Der Kem
Page 191 and 192: Slaunwhite WR, Burgett MJ. h virro
Page 193 and 194: 1.1 Preparation of dosing solution
Page 195 and 196: 1.4.6 Wash concentrate One bottle,
Page 197 and 198: 1.7.3 Estradiol controls Two vials.
Page 199 and 200: 1.1 1.2 Orcinol(6%) 6 g of orcinol
Page 201 and 202: 1.16.2 Horseradish peroxidase (8 Un
Page 203 and 204: 1.20 Superoxide dismutase 1.20.1 Tr
Page 205 and 206: 1.24.2 Thiobarbituric acid (TBA; 0.
Page 207 and 208: Chronic effect: of enclosulfan on t
Page 209: enbw1h1.W mu IUY Wcab unpiliml~t at
Page 212 and 213: cbniuis 11~11 b"nci:~lc ~wlive oxyg
Page 214 and 215: DNA, RNA ;uxl Wcin wcrr abarval, wh
Page 216 and 217: Mt~~m(10-lZsu&)vacob- Wfmn Ihehml ~
Page 218 and 219: New Delhi, llrliil Ib SCI~KK Rcm& M
Page 220 and 221: tiii~lc rcprmluction or rut (Cllitr
Page 222 and 223: wciglit (b.wt.) per day for 45 days
Page 224 and 225: 0.1 00 01 " 0.8 I . .lo Dl* rcnn IW
Page 228 and 229: C. hteboumyeradlos . KC. CMtn . P.P
Page 230 and 231: I. 1 Ilal 01 2 1.7 # I c I ~ ~ L I
Page 232 and 233: Fin. L Corrclatwn bclwfcn "perm cou
Page 235: Iionshii nepmdvctivc mxicity ad upt
Page 240 and 241: o. Glutathione reductage mg pmWn mg
Page 242 and 243: IOWAME -. Tor. #558517 PME: 9 SESS:
Page 244 and 245: JOBNAME: Rqm. Tm. M5W7 PAOB: 11 SBS
Page 246 and 247: t 02 ELSEVIER Toricology OM) (2W1)
Page 248 and 249: ---- - wcre obtu~ncd from E-Monk. G
Page 250: 3.2. A,III~AILNI syrlo~t of ,nIroch
Page 253 and 254: Uc,#!dy. SC. N;tdcru. S , 1% Conlrb
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