ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

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Fig. 24d. Effect of TCDD or TCDD and vitamin E on the activity of glutathione peroxidase in the kidney of adult rats (meanfSD; .P
7 REFERENCES Aitken RJ, Irvine DS, Wu FC. Generation of reactive oxygen species, lipid peroxidation in human sperm function. Biol Reprod 1989; 40: 183-1 97. Aitken RJ, Irvine DS, Wu FC. Perspective analysis of sperm-oocyte fusion and reactive oxygen species generation as criteria for the diagnosis of infertility. Am J Obstet Gynccol 1991; 164: 542-551. Allen JR, Lalich JJ. Response of chicken to prolonged feeding of crude 'toxic fat'. Proc Soc Exp Biol Med 1962; 109: 48-5 1. Baker CS, Magargee SF, Hammerstedt RH. Cholesterol transfer proteins from ram cauda cpididymal and seminal plasma. Biol Reprod 1993; 48: 11 I. Bardin CW, Brown TR, Mills NC, Gupta C, Bullock LP. The regulation of the P-glucuronidase gene by androgens and progestins. Biol Reprod 1978; 18: 74-83. Bardin CW, Cheng CV, Musto NA, Gunsalus GL. The Sertoli Cell. In: Knobil E , Neill JD (eds.), The Physiology of Reproduction, New York: Raven Press; 1988: 933-974. Bellve AR, Zbeng W. Different pleiotypic actions of seminiferous growth factor (SGF), acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF). Ann NY Acad Sci 1989; 564: 1 16- 13 1. Bergh A. Paracrine regulation of lxydig cells by the seminiferous tubules. Int J Androl 1983; 6: 57-65. Bergmeyer HU. P-Hydroxysteroid dehydrogenase. In: Bergmeyer HU (ed.), Methods of Enzymatic Analysis, New York: Academic Press: 1974: 447-489. Blauk WF, Treinen KA, Juniewicz PE. Application of testicular sperm head counts in the assessment of male reproductive toxicity. Methods Toxicol 1993; 3A: 86- 94. Bookataff RCM Kamel F, Moore RW, Bjerke DL, Peterson RE. Altered regulation of pituitary responsiveness to GnRH in 2,3.7.8-teuachlorodibenzo-pdioxin treated male rats. Toxicol Appl Pharmacol 1990; 105: 78-92. Brewster DW, Matsumura F, Akera T. Effect of 2.3.7.8-teuachlorodibenzo-pdioxin on the guinea pig heart muscle. Toxicol Appl Pharmacol 1987; 89: 408- 417. Brook DE. Metabolic activity in the epididymis and its regulation by androgens. Physiol Rev 1981; 61: 515-555. Bruchovsky N, Laser B, Van horn E, Craven S. I.Iormond ellbts: on cell proliferation in rat prostate. Vit Horm 1975; 33: 61 - 102. Buqe JA, Aust SD. Lactoperoxidax catalyzed lipid peroxiddon of microsomal and artificial membranes. Biochim Biophys Acta 1976; 444: -192-201.
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FUNCTIONAL STUDIES ON THE EFFECTS O
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ACKNOWLEDGEMENTS I wish to express
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TABLE OF CONTENTS Page No ACKNOWLED
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TABLE OF CONTENTS (Continued) Deter
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TABLE OF CONTENTS (Continued) Effec
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TAULIC OF CON'I'ISN'I'S (C'untinued
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xi LIST OF TABLES (Continued) I'agc
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Table 24a Table 24b Table 24c Table
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Fig. 1 Fig. 2 Effect of TCDD on the
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Fig. 12c Fig. 12d Fig. 13 Fig. 14a
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LIST OF FIGURES (Continued) Fig. 23
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LH M PL mg mRNA N AD NADH NADP NADP
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layers, an outer layer of visceral
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tubular epithelium and continually
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lmn~unization of monkeys against FS
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and this reaction is catalyzed by t
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extratubular environment or synthes
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the most active in protein secretio
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1958). A rapid fall in serum testos
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have also been reported in the rats
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Effect of TCDD on heart muscle has
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1.4 Effect of oxidative stress on m
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2 SCOPE OF THE PRESENT STUDY There
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3 MATERIALS AND METHODS 3.1 Animals
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Subgroup III: Administration of TCD
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choppcd with the help of sharp razo
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anti-FSH antibody. After incubation
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lust sped (500 to 700 rpm) on an or
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3.13.4 Quantitative determinntiun u
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The plates were dried by inverting
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centrifuged at 3,500 g for I5 min o
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3.17 Preparation of tiasue humogena
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supcrnutant was taken. Hlunk was pr
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3.21.4 Assay of glutathione peroxid
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4 RESULTS 4.1 Administration of TCD
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seminiferous tubules was found to b
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fractions of rat testis as compared
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4.1.11.1 Effect of TCDD on the prod
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4.2 Co-administration of TCDD and v
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4.2.8 Effect of co-administration o
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4.2.11.5 Effect of co-administratio
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Table I b. Effect of TCDD on the we
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Table 4. Effect of TCDD on the seru
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Table 7b. Effect of TCDD on the pro
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Table 8c. Effect of TCDD on the lev
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Table 9d. Effect of TCDD on the act
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Table 13. Effect of TCDD on the ant
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Table 15. Effect of TCDD on the lev
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Table 16c. Effcct of TCDD on the an
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Table 18a. Effect of co-administrat
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Table 21. Effect of co-administrati
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Table 24b. Effect of co-administrat
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Table 25c. Effect of co-administrat
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Table 26d. Effect of co-administrat
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Table 30. Effect of co-administrati
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Table 32. Effect of caadrninistrati
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Table 33c. Effcct of co-administrut
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5 DISCUSSION 5.1 Significance of th
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Measurement of weights of the acces
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compartment of the cells (Chainy el
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the reduction in daily sperm produc
Page 125 and 126: eported in the TCDD-treated rats (M
Page 127 and 128: lilnction is to ililcrccpt lipid pc
Page 129 and 130: in the animals administered with TC
Page 131 and 132: protective effects on serum testost
Page 133: suygcstccl that vivamin 1: conld im
Page 136 and 137: Fig.4~. ENect of TCDD or TCDD and v
Page 138: tE W d In w it I I (,OCX) 3s PUB (,
Page 142 and 143: Fig. 7c. Effect of TCDD or TCDD and
Page 145 and 146: u 3 f ~ = m w * N O .- ~Slew aew en
Page 147 and 148: Fig.lOb. ENmt of TCDD or TCDD and v
Page 151: Fig. 1Ir Effect of TCDD or TCDD md
Page 158 and 159: Fig. 14c. Effect of TCDD or TCDD an
Page 160 and 161: Fig. 16b. Effect of TCDD or TCDD an
Page 164 and 165: Fig.18~. EKect of TCDD or TCDD and
Page 166 and 167: 1 1.2 l4 Fig. 19b. ENect of TCDD or
Page 168 and 169: Fig. ZOb. Elkt of TCDD or TCDD and
Page 171 and 172: Fig. 21. Effect olTCDD or TCDD and
Page 173 and 174: Fig. 22c. Effect of TCDD or TCDD an
Page 175: Fig. 24b. Eflect ofTCDD or TCDD and
Page 179 and 180: Chitm KC, Latchoumycandanc,C, Mathu
Page 181 and 182: Flsher JS, Turner KJ, Brown D, Shar
Page 183 and 184: Hornsby PJ. Regulation of cytochrom
Page 185 and 186: Latcboumycandane C, Chitra KC, Math
Page 187 and 188: Moore RW, Panona JA, Bookstaff RC,
Page 189 and 190: Rommerts FFG, Cooke BA, Van Der Kem
Page 191 and 192: Slaunwhite WR, Burgett MJ. h virro
Page 193 and 194: 1.1 Preparation of dosing solution
Page 195 and 196: 1.4.6 Wash concentrate One bottle,
Page 197 and 198: 1.7.3 Estradiol controls Two vials.
Page 199 and 200: 1.1 1.2 Orcinol(6%) 6 g of orcinol
Page 201 and 202: 1.16.2 Horseradish peroxidase (8 Un
Page 203 and 204: 1.20 Superoxide dismutase 1.20.1 Tr
Page 205 and 206: 1.24.2 Thiobarbituric acid (TBA; 0.
Page 207 and 208: Chronic effect: of enclosulfan on t
Page 209: enbw1h1.W mu IUY Wcab unpiliml~t at
Page 212 and 213: cbniuis 11~11 b"nci:~lc ~wlive oxyg
Page 214 and 215: DNA, RNA ;uxl Wcin wcrr abarval, wh
Page 216 and 217: Mt~~m(10-lZsu&)vacob- Wfmn Ihehml ~
Page 218 and 219: New Delhi, llrliil Ib SCI~KK Rcm& M
Page 220 and 221: tiii~lc rcprmluction or rut (Cllitr
Page 222 and 223: wciglit (b.wt.) per day for 45 days
Page 224 and 225: 0.1 00 01 " 0.8 I . .lo Dl* rcnn IW
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Chilr:~. K.C.. L!olnn!myci!~dum. C.
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C. hteboumyeradlos . KC. CMtn . P.P
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I. 1 Ilal 01 2 1.7 # I c I ~ ~ L I
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Fin. L Corrclatwn bclwfcn "perm cou
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Iionshii nepmdvctivc mxicity ad upt
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o. Glutathione reductage mg pmWn mg
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IOWAME -. Tor. #558517 PME: 9 SESS:
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JOBNAME: Rqm. Tm. M5W7 PAOB: 11 SBS
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t 02 ELSEVIER Toricology OM) (2W1)
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---- - wcre obtu~ncd from E-Monk. G
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3.2. A,III~AILNI syrlo~t of ,nIroch
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Uc,#!dy. SC. N;tdcru. S , 1% Conlrb
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