ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

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DNA, RNA ;uxl Wcin wcrr abarval, whkh show Ihac wlive oxygcn rpccies WI atmk vllnl mnparnt~ or the all-like 11w1cic uci& and pieim. In oMlflusicm, che pant s!wh indiik bl )ind;ur sllrrs lwiUUlilr fuwtiam PhTiMy by i&ig rroctin: ~u).yl~ qxim md &ansing LI\C a~tiw.ii tnxyilcs lhuchy disrupting tntk rrpNJuEtion. Ilw: ;w~lxm hi~t cb SUIT o( Binbmwicn Centre, Wickny Univmicy, Rmdichary lor help. PPM &nnvlalw (he rtipl or iimisl rmn he I'M8 4: 2m - 6. Itl(ul;~~iis Cinl~il. New Y$11,. USA (CSUII Nth. WJJ. 17 LWIY OH, k- NJ. Ih AL. -1 K). !+*in M7P-I)/ lCMC onl t3YJ.W KM;). maurcmerr~U1PoBrr~reaa.IBblorm IR1; 198: %-15. I8 hlskhxi S. hbkhd 0. hwdVemn d -a nim References nbdh.liolldrbndm.dlm*ibn*ml I WH0lkp.m. l-prgrracm~rd~. lawcYnur. %I&mtem1974:.yU-l4 In: WIh ad Sufny M- 5( Unic (W.-) 19 CUbm A. C*.lr mivky. Ln: Onan*lld R. edlw IVJI: p 14, GKlmtu&dnrhoc(lfammrrknlmrch. Bax 2 aAnm7. n.nsdR.Su"Au.yurard RM. M; CRC Mi IW. pan-81. mlrrinc-diming ~ 4 ~ in ~ viMrlc 1 % rrl hmn. Enw- XI ~I.MnnsvU81.W~dcmEahnsnd nn HwXh IWJi 101: 378-8(. hRvmz,m~-fmrmIher. JBi :I Caxq.~ Kt.. Clsch&+ RW. RJrhab OL. GrUm IM. aa Irn, 261: M74-a,. Ik.111 KC. Ihn Jl,. M by. t!X~%i 41(l*cn hmn- El lk'tB,kbiY.Syuu&~nrrll~l.A,jmJaivlhy UI ~xlnll
Effect of lindane on antioxidant enzymes in epididymis and epididymal sperm of adult rats K.C. Chitre, R. Sujah, C. Latchoumycandanc, P.P. Malhur M#(lk-, Pm&myUn(wniy. W " y M Z O l 4 , Idk -: 1-1 Y -I epididymir: Mcioxidulai mUvc oxygen species Ab.tnct d lbr- W. h: h llerhllbd mis, hum we& ignitka& duaiona inin& qklkiy' nrlwdqhc.rpieQrml~~~~oDuadmocUiryrrmpndwlBth?~. SigniTmcdaMlerinchewpmjd. (80D),-, #atidam nhrPr d @uUthiare pm*duc dvitia ud signitmt inmaws in thc ~plarbodtlpld~~r*o~inUlscpididymirudepididyrmltprmoflindan~ucPted a. Lip*D dPElOIDl the bYOL of mdoddmf CN- in lk epididymia and epididyd ~gcrm of dor~WS~lndushp&wM. ( ~ ~ ~ ~ J A I ~ ~ ~ ~ W I S ~ ~ I S : M S - ~ I % O B ) ud d v e oxygen spkkr (ROS) thereby inducing ox- Mvc we&". ROS have bkn shorn a damage 81- most all chs rmcmmksvlcs of che dl incluing mm- LXUIO~O~~~~~~IWRWI f.lty~c/ds (WFA). CBUSiw hpnimm or plldor fudons[" ). Thc cpididyznis ir highly rW in RlFA aal lhusfoa suPcqxible IO (la &vs MO. &pcsm lo wvimnmenlal conlominpnl lindur bu tea Ibom lo enhsna oxidalive urrrr in liver and d"". Ihe -1 6lUdy WM wdcnnken I0 C- vducdc PL U T d ~ linJMs on che pnciaxht cmym d cpididymL ad epLWytrlnl yrnn ie &I1 NU. Iiadna (99%) w a gin fmn Jayhrishn. &tic&, Srbm. %nil Nadu. India. All Mhcr drmicnls
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FUNCTIONAL STUDIES ON THE EFFECTS O
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ACKNOWLEDGEMENTS I wish to express
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TABLE OF CONTENTS Page No ACKNOWLED
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TABLE OF CONTENTS (Continued) Deter
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TABLE OF CONTENTS (Continued) Effec
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TAULIC OF CON'I'ISN'I'S (C'untinued
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xi LIST OF TABLES (Continued) I'agc
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Table 24a Table 24b Table 24c Table
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Fig. 1 Fig. 2 Effect of TCDD on the
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Fig. 12c Fig. 12d Fig. 13 Fig. 14a
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LIST OF FIGURES (Continued) Fig. 23
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LH M PL mg mRNA N AD NADH NADP NADP
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layers, an outer layer of visceral
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tubular epithelium and continually
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lmn~unization of monkeys against FS
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and this reaction is catalyzed by t
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extratubular environment or synthes
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the most active in protein secretio
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1958). A rapid fall in serum testos
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have also been reported in the rats
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Effect of TCDD on heart muscle has
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1.4 Effect of oxidative stress on m
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2 SCOPE OF THE PRESENT STUDY There
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3 MATERIALS AND METHODS 3.1 Animals
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Subgroup III: Administration of TCD
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choppcd with the help of sharp razo
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anti-FSH antibody. After incubation
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lust sped (500 to 700 rpm) on an or
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3.13.4 Quantitative determinntiun u
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The plates were dried by inverting
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centrifuged at 3,500 g for I5 min o
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3.17 Preparation of tiasue humogena
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supcrnutant was taken. Hlunk was pr
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3.21.4 Assay of glutathione peroxid
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4 RESULTS 4.1 Administration of TCD
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seminiferous tubules was found to b
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fractions of rat testis as compared
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4.1.11.1 Effect of TCDD on the prod
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4.2 Co-administration of TCDD and v
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4.2.8 Effect of co-administration o
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4.2.11.5 Effect of co-administratio
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Table I b. Effect of TCDD on the we
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Table 4. Effect of TCDD on the seru
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Table 7b. Effect of TCDD on the pro
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Table 8c. Effect of TCDD on the lev
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Table 9d. Effect of TCDD on the act
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Table 13. Effect of TCDD on the ant
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Table 15. Effect of TCDD on the lev
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Table 16c. Effcct of TCDD on the an
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Table 18a. Effect of co-administrat
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Table 21. Effect of co-administrati
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Table 24b. Effect of co-administrat
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Table 25c. Effect of co-administrat
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Table 26d. Effect of co-administrat
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Table 30. Effect of co-administrati
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Table 32. Effect of caadrninistrati
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Table 33c. Effcct of co-administrut
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5 DISCUSSION 5.1 Significance of th
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Measurement of weights of the acces
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compartment of the cells (Chainy el
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the reduction in daily sperm produc
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eported in the TCDD-treated rats (M
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lilnction is to ililcrccpt lipid pc
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in the animals administered with TC
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protective effects on serum testost
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suygcstccl that vivamin 1: conld im
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Fig.4~. ENect of TCDD or TCDD and v
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tE W d In w it I I (,OCX) 3s PUB (,
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Fig. 7c. Effect of TCDD or TCDD and
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u 3 f ~ = m w * N O .- ~Slew aew en
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Fig.lOb. ENmt of TCDD or TCDD and v
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Fig. 1Ir Effect of TCDD or TCDD md
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Fig. 14c. Effect of TCDD or TCDD an
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Fig. 16b. Effect of TCDD or TCDD an
Page 164 and 165: Fig.18~. EKect of TCDD or TCDD and
Page 166 and 167: 1 1.2 l4 Fig. 19b. ENect of TCDD or
Page 168 and 169: Fig. ZOb. Elkt of TCDD or TCDD and
Page 171 and 172: Fig. 21. Effect olTCDD or TCDD and
Page 173 and 174: Fig. 22c. Effect of TCDD or TCDD an
Page 175 and 176: Fig. 24b. Eflect ofTCDD or TCDD and
Page 177 and 178: 7 REFERENCES Aitken RJ, Irvine DS,
Page 179 and 180: Chitm KC, Latchoumycandanc,C, Mathu
Page 181 and 182: Flsher JS, Turner KJ, Brown D, Shar
Page 183 and 184: Hornsby PJ. Regulation of cytochrom
Page 185 and 186: Latcboumycandane C, Chitra KC, Math
Page 187 and 188: Moore RW, Panona JA, Bookstaff RC,
Page 189 and 190: Rommerts FFG, Cooke BA, Van Der Kem
Page 191 and 192: Slaunwhite WR, Burgett MJ. h virro
Page 193 and 194: 1.1 Preparation of dosing solution
Page 195 and 196: 1.4.6 Wash concentrate One bottle,
Page 197 and 198: 1.7.3 Estradiol controls Two vials.
Page 199 and 200: 1.1 1.2 Orcinol(6%) 6 g of orcinol
Page 201 and 202: 1.16.2 Horseradish peroxidase (8 Un
Page 203 and 204: 1.20 Superoxide dismutase 1.20.1 Tr
Page 205 and 206: 1.24.2 Thiobarbituric acid (TBA; 0.
Page 207 and 208: Chronic effect: of enclosulfan on t
Page 209: enbw1h1.W mu IUY Wcab unpiliml~t at
Page 212 and 213: cbniuis 11~11 b"nci:~lc ~wlive oxyg
Page 216 and 217: Mt~~m(10-lZsu&)vacob- Wfmn Ihehml ~
Page 218 and 219: New Delhi, llrliil Ib SCI~KK Rcm& M
Page 220 and 221: tiii~lc rcprmluction or rut (Cllitr
Page 222 and 223: wciglit (b.wt.) per day for 45 days
Page 224 and 225: 0.1 00 01 " 0.8 I . .lo Dl* rcnn IW
Page 226 and 227: Chilr:~. K.C.. L!olnn!myci!~dum. C.
Page 228 and 229: C. hteboumyeradlos . KC. CMtn . P.P
Page 230 and 231: I. 1 Ilal 01 2 1.7 # I c I ~ ~ L I
Page 232 and 233: Fin. L Corrclatwn bclwfcn "perm cou
Page 235: Iionshii nepmdvctivc mxicity ad upt
Page 240 and 241: o. Glutathione reductage mg pmWn mg
Page 242 and 243: IOWAME -. Tor. #558517 PME: 9 SESS:
Page 244 and 245: JOBNAME: Rqm. Tm. M5W7 PAOB: 11 SBS
Page 246 and 247: t 02 ELSEVIER Toricology OM) (2W1)
Page 248 and 249: ---- - wcre obtu~ncd from E-Monk. G
Page 250: 3.2. A,III~AILNI syrlo~t of ,nIroch
Page 253 and 254: Uc,#!dy. SC. N;tdcru. S , 1% Conlrb
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