ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

(Latchuumycandane el ul.. 2002 b). Uccrcasod activitics of antioxidant cnzymcs and
increased levels of lipid peroxidation in the epididymal sperm could rcveal the
adverse effect of TCDD on the antioxidant system of rats.
5.2.9 Effect of TCDD on antioxidant system in the caput, corpus and cauda
epididymides
Administration of TCDD increased the production of superoxide anion, nitric
oxide and hydrogen peroxide in the caput, corpus and cauda epididymides of rats
when compared to the corresponding groups of control animals (Fig. 18a to 18c;
'Table 14). Administration of TCDD decreased the levels of antioxidants such as
glutathione and a-tocopherol in the caput, corpus and cauda epididymides of rats
(Fig. l9a & 19b; Table 15). Administration of TCDD decreased the activities of
superoxide dismutase. catalase, glutathione reductase and glutathione peroxidase (Fig.
20a to 2Od; Table 16a to 16c), while the level of lipid peroxidation incroascd
s~gnificantly in the caput, corpus and cauda epididymides of rats (Fig. 21: Table 16a
to 16c). Similar observation has also been reported in caput, corpus and cauda
epididymides of rats foIlowing treatment with lindane (Chitra eta/.. 2001).
5.2.10 Effect of TCDD on antioxidant system in kidney
Administration of TCDD at the dose level of 100 ngl Kg body weight! day
increased the production of superoxide anion, nitric oxide and hydrogen peroxide in
the kidney of rats when compared to the corresponding groups of control animals
(Fig. 22a to 22c; Table 17a). TCDD decreased the levels of antioxidants such as
glutathione and a-tocopherol in the kidney of rats at 100 ng dose level (Fig.23a L
23b; Table 17b) when compared to the corresponding groups of control animals.
Administration of TCDD decreased the activities of superoxide dismutase. catalase.
glutathione reductase and glutathione peroxidase at 100 ng dose level (Fig. 24a to
24d; Table 17c) while the level of lipid petoxidation increased significantly in the
kidney of rats (Fig. 25: Table 17c). However, no significant changes were observed