ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

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~lLllc mu ~LYIC~L~ II*: ~[IL'IIII WIIIS ill UC u~UJ..II cpi. didyt~lis :eul d,c izi~nacs~icul;~r slrniuilid rw11u, ilrur;i. .ILI iviilr uii ck~rrIio~i tii UIC xlivili~ of sl~xific IG\I~CU. rru~gc~ri~J using Ralli R~llu-Uvd!jcni Inx~n~gcnircr. I0 5, I ~ul~t~wlC Wuv prclmi~d ill IUWIEII s:ilittt: ~1 11 si~p,~l;runi ru.ul lw Iiicrlu~rio~l &'d:1y. 'llr cxrr*cii, 1;v ~ii;utcr CII~IIW. s so~lrilol dcl~yhwga~w, IWLIC u~rl ~klmniwtion of M A mlJ RNA m wnie~ ~kliydmgcir:~~!, ~.glur.u:~yl muqrpl~d:~~ uul gluc.cru C. !ull~,wi~rg Ur l
enbw1h1.W mu IUY Wcab unpiliml~t at &ticactivity ilrw with llic dcvclojr~~~e~ti of sr~ntr;,lo Ub. piluilalY. Cf ~1yp~IPliY1lic lcwl, 'nu ~pididyi~ii~, C~ICK~"'~. Acliviliu; ot truc ly~u,~~ul UIL~IU !wvr iull :cini~ud wick wid vc~~utll INWUI~: an: tl11 ul&rwl. dwWl\ In nu, dm enlicuhr slcruicbgc~uiis il; ill. ~&lI orpimr, dying On ICstoslM~ ,fur kir ucuu~I'*'~. A &acmc in UIC %id ohosDhahr ill lrer grwnh nnd fUnclion[lol. A rcducljon in (heir wcidlk stlr ww~d bus rcthl d d lesicu~pr smido8em- 11uy r c b u ~ Jcuwred bianvi~ilability wd pralunion of sis in Ur W - m u ad UI my ba cmdnkd will1 1110 aI~enr("'. ducal rasrerion of g ~ p h i A ~ deacare . in tk nl!dinc phosphaurw ocuvity in cndosulfan.mlcd n$ in- J i W lhnl emlobulf~~~ unLrw111 prduccd s sue of deurarcd stMidogwcris whuc Ihc inrcr- and invrcllular Wnrporr Was &ccd as rhc melabolic d m lo channnlize the MU~Y~ input8 for slemidogurais slowed do*n("l. In conclusion, 'he own1 studics indicate hat en- Pmeid IO..%tz.r) 13.12+1.lrF IINA' ll.l:l*l.:L~~ ?,i9*(1,#~> WIA' ;1.1')tU.W 0.93t0.2ib AX.5.W acid' 2.5+0.81 I.M+O.IP LYw' 4.5.08+7. 32.64+Y.L? M-2 31.nts.m 1r.utz.w 3 POH.uarxd 3.WtI.W l.e8*0.31" JC~>*IWJ Aca -y' 10L.07+25.1 79.%~10,&5~ Wim phy.p"ouel W.50r.X.42 55.61*15.2UL ' III~L wet wcidll 01 1 ~~1~s ln~~~V~og 11tu1ein ' ruwl of NAD conuuled lo NADIUmidnrp pmlcin 'l,nwl rt.~~~~~~~l~lw~~~l IIIC~;~I~I~:I~ T/::lI III~II/IIXI (21; I8,Ulflll PPM sc*norvlcgcs the rscipl of financial support horn Uc Popllation Council, New York. USA. References 1 WllO kpn. Inlau!hm! yropmmr m c l a d olsly. In, Lv(mwW IWL Cri~iu-W. Gx!dlu~ L WllD. Gus"") 1w: I. 2 Siwl, SK, lbrky US 'rvricilg or ctuknilr.lll ax! LLlirg ,,I llule NY LI .IYIIUI le chg nrohiiul~s c~u)%sa ;yul ltucm. rarrrl lipicl pwrilluim. llwlisll J Lp llid I'm): 27: 725 - :I l\>l.b" VII, l\$d
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FUNCTIONAL STUDIES ON THE EFFECTS O
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ACKNOWLEDGEMENTS I wish to express
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TABLE OF CONTENTS Page No ACKNOWLED
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TABLE OF CONTENTS (Continued) Deter
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TABLE OF CONTENTS (Continued) Effec
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TAULIC OF CON'I'ISN'I'S (C'untinued
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xi LIST OF TABLES (Continued) I'agc
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Table 24a Table 24b Table 24c Table
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Fig. 1 Fig. 2 Effect of TCDD on the
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Fig. 12c Fig. 12d Fig. 13 Fig. 14a
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LIST OF FIGURES (Continued) Fig. 23
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LH M PL mg mRNA N AD NADH NADP NADP
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layers, an outer layer of visceral
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tubular epithelium and continually
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lmn~unization of monkeys against FS
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and this reaction is catalyzed by t
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extratubular environment or synthes
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the most active in protein secretio
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1958). A rapid fall in serum testos
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have also been reported in the rats
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Effect of TCDD on heart muscle has
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1.4 Effect of oxidative stress on m
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2 SCOPE OF THE PRESENT STUDY There
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3 MATERIALS AND METHODS 3.1 Animals
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Subgroup III: Administration of TCD
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choppcd with the help of sharp razo
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anti-FSH antibody. After incubation
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lust sped (500 to 700 rpm) on an or
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3.13.4 Quantitative determinntiun u
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The plates were dried by inverting
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centrifuged at 3,500 g for I5 min o
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3.17 Preparation of tiasue humogena
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supcrnutant was taken. Hlunk was pr
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3.21.4 Assay of glutathione peroxid
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4 RESULTS 4.1 Administration of TCD
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seminiferous tubules was found to b
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fractions of rat testis as compared
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4.1.11.1 Effect of TCDD on the prod
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4.2 Co-administration of TCDD and v
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4.2.8 Effect of co-administration o
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4.2.11.5 Effect of co-administratio
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Table I b. Effect of TCDD on the we
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Table 4. Effect of TCDD on the seru
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Table 7b. Effect of TCDD on the pro
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Table 8c. Effect of TCDD on the lev
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Table 9d. Effect of TCDD on the act
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Table 13. Effect of TCDD on the ant
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Table 15. Effect of TCDD on the lev
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Table 16c. Effcct of TCDD on the an
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Table 18a. Effect of co-administrat
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Table 21. Effect of co-administrati
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Table 24b. Effect of co-administrat
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Table 25c. Effect of co-administrat
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Table 26d. Effect of co-administrat
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Table 30. Effect of co-administrati
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Table 32. Effect of caadrninistrati
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Table 33c. Effcct of co-administrut
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5 DISCUSSION 5.1 Significance of th
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Measurement of weights of the acces
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compartment of the cells (Chainy el
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the reduction in daily sperm produc
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eported in the TCDD-treated rats (M
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lilnction is to ililcrccpt lipid pc
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in the animals administered with TC
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protective effects on serum testost
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suygcstccl that vivamin 1: conld im
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Fig.4~. ENect of TCDD or TCDD and v
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tE W d In w it I I (,OCX) 3s PUB (,
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Fig. 7c. Effect of TCDD or TCDD and
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u 3 f ~ = m w * N O .- ~Slew aew en
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Fig.lOb. ENmt of TCDD or TCDD and v
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Fig. 1Ir Effect of TCDD or TCDD md
Page 158 and 159: Fig. 14c. Effect of TCDD or TCDD an
Page 160 and 161: Fig. 16b. Effect of TCDD or TCDD an
Page 164 and 165: Fig.18~. EKect of TCDD or TCDD and
Page 166 and 167: 1 1.2 l4 Fig. 19b. ENect of TCDD or
Page 168 and 169: Fig. ZOb. Elkt of TCDD or TCDD and
Page 171 and 172: Fig. 21. Effect olTCDD or TCDD and
Page 173 and 174: Fig. 22c. Effect of TCDD or TCDD an
Page 175 and 176: Fig. 24b. Eflect ofTCDD or TCDD and
Page 177 and 178: 7 REFERENCES Aitken RJ, Irvine DS,
Page 179 and 180: Chitm KC, Latchoumycandanc,C, Mathu
Page 181 and 182: Flsher JS, Turner KJ, Brown D, Shar
Page 183 and 184: Hornsby PJ. Regulation of cytochrom
Page 185 and 186: Latcboumycandane C, Chitra KC, Math
Page 187 and 188: Moore RW, Panona JA, Bookstaff RC,
Page 189 and 190: Rommerts FFG, Cooke BA, Van Der Kem
Page 191 and 192: Slaunwhite WR, Burgett MJ. h virro
Page 193 and 194: 1.1 Preparation of dosing solution
Page 195 and 196: 1.4.6 Wash concentrate One bottle,
Page 197 and 198: 1.7.3 Estradiol controls Two vials.
Page 199 and 200: 1.1 1.2 Orcinol(6%) 6 g of orcinol
Page 201 and 202: 1.16.2 Horseradish peroxidase (8 Un
Page 203 and 204: 1.20 Superoxide dismutase 1.20.1 Tr
Page 205 and 206: 1.24.2 Thiobarbituric acid (TBA; 0.
Page 207: Chronic effect: of enclosulfan on t
Page 212 and 213: cbniuis 11~11 b"nci:~lc ~wlive oxyg
Page 214 and 215: DNA, RNA ;uxl Wcin wcrr abarval, wh
Page 216 and 217: Mt~~m(10-lZsu&)vacob- Wfmn Ihehml ~
Page 218 and 219: New Delhi, llrliil Ib SCI~KK Rcm& M
Page 220 and 221: tiii~lc rcprmluction or rut (Cllitr
Page 222 and 223: wciglit (b.wt.) per day for 45 days
Page 224 and 225: 0.1 00 01 " 0.8 I . .lo Dl* rcnn IW
Page 226 and 227: Chilr:~. K.C.. L!olnn!myci!~dum. C.
Page 228 and 229: C. hteboumyeradlos . KC. CMtn . P.P
Page 230 and 231: I. 1 Ilal 01 2 1.7 # I c I ~ ~ L I
Page 232 and 233: Fin. L Corrclatwn bclwfcn "perm cou
Page 235: Iionshii nepmdvctivc mxicity ad upt
Page 240 and 241: o. Glutathione reductage mg pmWn mg
Page 242 and 243: IOWAME -. Tor. #558517 PME: 9 SESS:
Page 244 and 245: JOBNAME: Rqm. Tm. M5W7 PAOB: 11 SBS
Page 246 and 247: t 02 ELSEVIER Toricology OM) (2W1)
Page 248 and 249: ---- - wcre obtu~ncd from E-Monk. G
Page 250: 3.2. A,III~AILNI syrlo~t of ,nIroch
Page 253 and 254: Uc,#!dy. SC. N;tdcru. S , 1% Conlrb
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