ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

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TABLE OF CONTENTS (Cuntinucul) Effect of TCDD on the testicular sleroidogencsis Effect of TCDD on nucleic acids and protein contents in testis Effect of TCDD on the production of reactive oxygen species in the crude homogenate, mitochondrial and ~nicrosome-rich fractions of testis of rats Effect of TCDD on the levels of antioxidants in the crude homogenate, mitochondrial and microsome-rich fractions of testis of rats Effect of TCDD on the antioxidant enzymes and lipid peroxidation in crude homopennte. mitochondrial and microsomc-rich l'ractions of testis of rat Effect of TCDD on the epididymal sperm and epididymis Effect of TCDD on the production of reaclive oxygen species in the epididymal sperm of adult rats Effect of TCDD on the levels of antioxidants in the epididymal sperm of adult rats Effect of TCDD on the antioxidant enzymes and lipid peroxidation in the epididymal sperm of adult rats Effect of TCDD on the production of reactive oxygen spccies in the capuc. corpus and cauda epididymides of adult rats Effect of TCDD on the antioxidants in the caput, corpus and cauda epididymides of adult rats 4.1 .I 1.6 Effect of TCDD on the antioxidant enzymes and lipid peroxidation in the caput. corpus and cauda epididymides of adult rats 4.1.12 Effects of TCDD on the levels of reactive oxygen species production, antioxidants, antioxidant enzymes and lipid peroxidation in kidney 4.2 Co-administration of TCDD and Vitamin E to Rats 4.2.1 Eflbcl or co-administration oTT
TABLE OF CONTENTS (Continued) Effect of co-administration of TCDD and vitaniin E on seminiferous tubular and lumen diamcter Effect of co-administration of TCDD and vitamin E on the levels of serum hormones Effect of co-administration of TCDD and vitamin E on thc testicular steroidogenesis Effect of co-administration of TCDD and vitamin E on nucleic acids and protein contents of testis Effect of co-administration of TCDD and vitamin E on the production of reactive oxygen species in the crude homogenate, mitochondrial and microsome-rich fractions of testis of rats Effect of co-administration of TCDD and vitamin E on the levels of antioxidants in the crude homogenate, mitochondria1 and microsome-rich fractions of testis of rats Effect of co-administration of TCDD and vitamin E on the antioxidant enzymes and lipid peroxidation in crude homogenate, mitochondria1 and microsome-rich fractions of testis of rats Effect of co-administration of TCDD and vitamin E on the epididymal sperm of adult rats Effect of co-administration of TCDD and vitamin I: on tlic production of reactive oxygen species in the epididymal sperm of adult rats Effect of co-administration of TCDD and vitamin E on the levels of antioxidant in the epididymal sperm of adult rat Effect of co-administration of TCDD and vitamin E on the antioxidant enzymes and lipid peroxidation in the epididymal sperm of adult rats Effect of co-administration of TCDD and vitamin E on the production of reactive oxygen species in the caput, corpus and cnudn cpididyniidcs of adnlt rats EHbct of co-administration of 'fCDD and vitamin Li on thc antioxidants in the caput. corpus and cauda epididyniidcs of adult rats El'f'ect of co-administration of I'CDD and vitamin li on thc antioxidant enzymes and lipid peroxidation in the caput. corpus and cauda epididymides of adult rats vii Page No 56
Page 1 and 2: FUNCTIONAL STUDIES ON THE EFFECTS O
Page 3 and 4: ACKNOWLEDGEMENTS I wish to express
Page 5 and 6: TABLE OF CONTENTS Page No ACKNOWLED
Page 7: TABLE OF CONTENTS (Continued) Deter
Page 11 and 12: TAULIC OF CON'I'ISN'I'S (C'untinued
Page 13 and 14: xi LIST OF TABLES (Continued) I'agc
Page 15 and 16: Table 24a Table 24b Table 24c Table
Page 17 and 18: Fig. 1 Fig. 2 Effect of TCDD on the
Page 19 and 20: Fig. 12c Fig. 12d Fig. 13 Fig. 14a
Page 21 and 22: LIST OF FIGURES (Continued) Fig. 23
Page 23 and 24: LH M PL mg mRNA N AD NADH NADP NADP
Page 25 and 26: layers, an outer layer of visceral
Page 27 and 28: tubular epithelium and continually
Page 29 and 30: lmn~unization of monkeys against FS
Page 31 and 32: and this reaction is catalyzed by t
Page 33 and 34: extratubular environment or synthes
Page 35 and 36: the most active in protein secretio
Page 37 and 38: 1958). A rapid fall in serum testos
Page 39 and 40: have also been reported in the rats
Page 41 and 42: Effect of TCDD on heart muscle has
Page 43 and 44: 1.4 Effect of oxidative stress on m
Page 45 and 46: 2 SCOPE OF THE PRESENT STUDY There
Page 47 and 48: 3 MATERIALS AND METHODS 3.1 Animals
Page 49 and 50: Subgroup III: Administration of TCD
Page 51 and 52: choppcd with the help of sharp razo
Page 53 and 54: anti-FSH antibody. After incubation
Page 55 and 56: lust sped (500 to 700 rpm) on an or
Page 57 and 58: 3.13.4 Quantitative determinntiun u
Page 59 and 60:
The plates were dried by inverting
Page 61 and 62:
centrifuged at 3,500 g for I5 min o
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3.17 Preparation of tiasue humogena
Page 65 and 66:
supcrnutant was taken. Hlunk was pr
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3.21.4 Assay of glutathione peroxid
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4 RESULTS 4.1 Administration of TCD
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seminiferous tubules was found to b
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fractions of rat testis as compared
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4.1.11.1 Effect of TCDD on the prod
Page 78 and 79:
4.2 Co-administration of TCDD and v
Page 80 and 81:
4.2.8 Effect of co-administration o
Page 82 and 83:
4.2.11.5 Effect of co-administratio
Page 84 and 85:
Table I b. Effect of TCDD on the we
Page 86 and 87:
Table 4. Effect of TCDD on the seru
Page 88 and 89:
Table 7b. Effect of TCDD on the pro
Page 90 and 91:
Table 8c. Effect of TCDD on the lev
Page 92 and 93:
Table 9d. Effect of TCDD on the act
Page 94 and 95:
Table 13. Effect of TCDD on the ant
Page 96 and 97:
Table 15. Effect of TCDD on the lev
Page 98 and 99:
Table 16c. Effcct of TCDD on the an
Page 100 and 101:
Table 18a. Effect of co-administrat
Page 103 and 104:
Table 21. Effect of co-administrati
Page 105 and 106:
Table 24b. Effect of co-administrat
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Table 25c. Effect of co-administrat
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Table 26d. Effect of co-administrat
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Table 30. Effect of co-administrati
Page 113 and 114:
Table 32. Effect of caadrninistrati
Page 115 and 116:
Table 33c. Effcct of co-administrut
Page 117 and 118:
5 DISCUSSION 5.1 Significance of th
Page 119 and 120:
Measurement of weights of the acces
Page 121 and 122:
compartment of the cells (Chainy el
Page 123 and 124:
the reduction in daily sperm produc
Page 125 and 126:
eported in the TCDD-treated rats (M
Page 127 and 128:
lilnction is to ililcrccpt lipid pc
Page 129 and 130:
in the animals administered with TC
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protective effects on serum testost
Page 133:
suygcstccl that vivamin 1: conld im
Page 136 and 137:
Fig.4~. ENect of TCDD or TCDD and v
Page 138:
tE W d In w it I I (,OCX) 3s PUB (,
Page 142 and 143:
Fig. 7c. Effect of TCDD or TCDD and
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u 3 f ~ = m w * N O .- ~Slew aew en
Page 147 and 148:
Fig.lOb. ENmt of TCDD or TCDD and v
Page 151:
Fig. 1Ir Effect of TCDD or TCDD md
Page 158 and 159:
Fig. 14c. Effect of TCDD or TCDD an
Page 160 and 161:
Fig. 16b. Effect of TCDD or TCDD an
Page 164 and 165:
Fig.18~. EKect of TCDD or TCDD and
Page 166 and 167:
1 1.2 l4 Fig. 19b. ENect of TCDD or
Page 168 and 169:
Fig. ZOb. Elkt of TCDD or TCDD and
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Fig. 21. Effect olTCDD or TCDD and
Page 173 and 174:
Fig. 22c. Effect of TCDD or TCDD an
Page 175 and 176:
Fig. 24b. Eflect ofTCDD or TCDD and
Page 177 and 178:
7 REFERENCES Aitken RJ, Irvine DS,
Page 179 and 180:
Chitm KC, Latchoumycandanc,C, Mathu
Page 181 and 182:
Flsher JS, Turner KJ, Brown D, Shar
Page 183 and 184:
Hornsby PJ. Regulation of cytochrom
Page 185 and 186:
Latcboumycandane C, Chitra KC, Math
Page 187 and 188:
Moore RW, Panona JA, Bookstaff RC,
Page 189 and 190:
Rommerts FFG, Cooke BA, Van Der Kem
Page 191 and 192:
Slaunwhite WR, Burgett MJ. h virro
Page 193 and 194:
1.1 Preparation of dosing solution
Page 195 and 196:
1.4.6 Wash concentrate One bottle,
Page 197 and 198:
1.7.3 Estradiol controls Two vials.
Page 199 and 200:
1.1 1.2 Orcinol(6%) 6 g of orcinol
Page 201 and 202:
1.16.2 Horseradish peroxidase (8 Un
Page 203 and 204:
1.20 Superoxide dismutase 1.20.1 Tr
Page 205 and 206:
1.24.2 Thiobarbituric acid (TBA; 0.
Page 207 and 208:
Chronic effect: of enclosulfan on t
Page 209:
enbw1h1.W mu IUY Wcab unpiliml~t at
Page 212 and 213:
cbniuis 11~11 b"nci:~lc ~wlive oxyg
Page 214 and 215:
DNA, RNA ;uxl Wcin wcrr abarval, wh
Page 216 and 217:
Mt~~m(10-lZsu&)vacob- Wfmn Ihehml ~
Page 218 and 219:
New Delhi, llrliil Ib SCI~KK Rcm& M
Page 220 and 221:
tiii~lc rcprmluction or rut (Cllitr
Page 222 and 223:
wciglit (b.wt.) per day for 45 days
Page 224 and 225:
0.1 00 01 " 0.8 I . .lo Dl* rcnn IW
Page 226 and 227:
Chilr:~. K.C.. L!olnn!myci!~dum. C.
Page 228 and 229:
C. hteboumyeradlos . KC. CMtn . P.P
Page 230 and 231:
I. 1 Ilal 01 2 1.7 # I c I ~ ~ L I
Page 232 and 233:
Fin. L Corrclatwn bclwfcn "perm cou
Page 235:
Iionshii nepmdvctivc mxicity ad upt
Page 240 and 241:
o. Glutathione reductage mg pmWn mg
Page 242 and 243:
IOWAME -. Tor. #558517 PME: 9 SESS:
Page 244 and 245:
JOBNAME: Rqm. Tm. M5W7 PAOB: 11 SBS
Page 246 and 247:
t 02 ELSEVIER Toricology OM) (2W1)
Page 248 and 249:
---- - wcre obtu~ncd from E-Monk. G
Page 250:
3.2. A,III~AILNI syrlo~t of ,nIroch
Page 253 and 254:
Uc,#!dy. SC. N;tdcru. S , 1% Conlrb
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