- Page 1 and 2:
FUNCTIONAL STUDIES ON THE EFFECTS O
- Page 3 and 4:
ACKNOWLEDGEMENTS I wish to express
- Page 5 and 6:
TABLE OF CONTENTS Page No ACKNOWLED
- Page 7 and 8:
TABLE OF CONTENTS (Continued) Deter
- Page 9 and 10:
TABLE OF CONTENTS (Continued) Effec
- Page 11 and 12:
TAULIC OF CON'I'ISN'I'S (C'untinued
- Page 13 and 14:
xi LIST OF TABLES (Continued) I'agc
- Page 15 and 16:
Table 24a Table 24b Table 24c Table
- Page 17 and 18:
Fig. 1 Fig. 2 Effect of TCDD on the
- Page 19 and 20:
Fig. 12c Fig. 12d Fig. 13 Fig. 14a
- Page 21 and 22:
LIST OF FIGURES (Continued) Fig. 23
- Page 23 and 24:
LH M PL mg mRNA N AD NADH NADP NADP
- Page 25 and 26:
layers, an outer layer of visceral
- Page 27 and 28:
tubular epithelium and continually
- Page 29 and 30:
lmn~unization of monkeys against FS
- Page 31 and 32:
and this reaction is catalyzed by t
- Page 33 and 34:
extratubular environment or synthes
- Page 35 and 36:
the most active in protein secretio
- Page 37 and 38:
1958). A rapid fall in serum testos
- Page 39 and 40:
have also been reported in the rats
- Page 41 and 42:
Effect of TCDD on heart muscle has
- Page 43 and 44:
1.4 Effect of oxidative stress on m
- Page 45 and 46:
2 SCOPE OF THE PRESENT STUDY There
- Page 47 and 48:
3 MATERIALS AND METHODS 3.1 Animals
- Page 49 and 50:
Subgroup III: Administration of TCD
- Page 51 and 52:
choppcd with the help of sharp razo
- Page 53 and 54:
anti-FSH antibody. After incubation
- Page 55 and 56:
lust sped (500 to 700 rpm) on an or
- Page 57 and 58:
3.13.4 Quantitative determinntiun u
- Page 59 and 60:
The plates were dried by inverting
- Page 61 and 62:
centrifuged at 3,500 g for I5 min o
- Page 63 and 64:
3.17 Preparation of tiasue humogena
- Page 65 and 66:
supcrnutant was taken. Hlunk was pr
- Page 67 and 68:
3.21.4 Assay of glutathione peroxid
- Page 69:
4 RESULTS 4.1 Administration of TCD
- Page 72 and 73:
seminiferous tubules was found to b
- Page 74 and 75:
fractions of rat testis as compared
- Page 76 and 77:
4.1.11.1 Effect of TCDD on the prod
- Page 78 and 79:
4.2 Co-administration of TCDD and v
- Page 80 and 81:
4.2.8 Effect of co-administration o
- Page 82 and 83:
4.2.11.5 Effect of co-administratio
- Page 84 and 85:
Table I b. Effect of TCDD on the we
- Page 86 and 87:
Table 4. Effect of TCDD on the seru
- Page 88 and 89: Table 7b. Effect of TCDD on the pro
- Page 90 and 91: Table 8c. Effect of TCDD on the lev
- Page 92 and 93: Table 9d. Effect of TCDD on the act
- Page 94 and 95: Table 13. Effect of TCDD on the ant
- Page 96 and 97: Table 15. Effect of TCDD on the lev
- Page 98 and 99: Table 16c. Effcct of TCDD on the an
- Page 100 and 101: Table 18a. Effect of co-administrat
- Page 103 and 104: Table 21. Effect of co-administrati
- Page 105 and 106: Table 24b. Effect of co-administrat
- Page 107 and 108: Table 25c. Effect of co-administrat
- Page 109 and 110: Table 26d. Effect of co-administrat
- Page 111 and 112: Table 30. Effect of co-administrati
- Page 113 and 114: Table 32. Effect of caadrninistrati
- Page 115 and 116: Table 33c. Effcct of co-administrut
- Page 117 and 118: 5 DISCUSSION 5.1 Significance of th
- Page 119 and 120: Measurement of weights of the acces
- Page 121 and 122: compartment of the cells (Chainy el
- Page 123 and 124: the reduction in daily sperm produc
- Page 125 and 126: eported in the TCDD-treated rats (M
- Page 127 and 128: lilnction is to ililcrccpt lipid pc
- Page 129 and 130: in the animals administered with TC
- Page 131 and 132: protective effects on serum testost
- Page 133: suygcstccl that vivamin 1: conld im
- Page 136 and 137: Fig.4~. ENect of TCDD or TCDD and v
- Page 138: tE W d In w it I I (,OCX) 3s PUB (,
- Page 143: Fig. 7c. ElTect of TCDD or TCDD and
- Page 146 and 147: Fig.lOa. EBut of TCDD or TCDD and v
- Page 148: Filk Effect of TCDD or TCDD and vit
- Page 157 and 158: Fig. 14a. Effect of TCDD or TCDD an
- Page 159 and 160: Fig. 1Sb. Effect of TCDD or TCDD an
- Page 161: Fig.16d. Effect of TCDD or TCDD and
- Page 165 and 166: Fig. 19a. Effect of TCDD or TCDD an
- Page 167 and 168: 60 Fig. 20a. Effect of TCDD or TCDD
- Page 169: Fig. 2k. Ekt of TCDD or TCDD and vi
- Page 172 and 173: Fig. 22a. EKect of TCDD or TCDD and
- Page 174 and 175: Fig. 23b. Effect of TCDD or TCDD an
- Page 176 and 177: Fig. 24d. Effect of TCDD or TCDD an
- Page 178 and 179: Burkhart ER. A study of the early e
- Page 180 and 181: de Kretaer DM. In: The Testis. Burg
- Page 182 and 183: Griawold MD. Protein secretion by S
- Page 184 and 185: June NHPM, Jansen R, Grootegoed JA,
- Page 186 and 187: Mathur PP, Mo MY, Panzironi C, Silv
- Page 188 and 189: Petenon RE, Scefeld MD, Christian W
- Page 190 and 191:
Shan LX. Hardy MP. Developmental ch
- Page 192 and 193:
Tindall DJ, MiUer DA, Means AR. Cha
- Page 194 and 195:
1.3.4 Antibody-Enzyme Conjugate sol
- Page 196 and 197:
1.6.2 Testosterone standards One vi
- Page 198 and 199:
22.91 pg of 4-androstcne 3,17-dione
- Page 200 and 201:
1.13 Subcellulnr frnctionation of t
- Page 202 and 203:
1.17.4 Disodium hydrogen phosphate
- Page 204 and 205:
1.22.2 NADPH (0.2 pM) 16.6672 mg of
- Page 206 and 207:
APPENDIX 2 LIST OF PUBLICATIONS OF
- Page 208 and 209:
~lLllc mu ~LYIC~L~ II*: ~[IL'IIII W
- Page 211 and 212:
Effect of lindane on testicular ant
- Page 213 and 214:
ILXlll hnl, .I 121; 1.0 -/.a . Ill
- Page 215 and 216:
Effect of lindane on antioxidant en
- Page 217 and 218:
WnCr, inyminn~nt of spmri motility,
- Page 219 and 220:
The effect of 2,3,7,8-tetrachlorodi
- Page 221 and 222:
I kl
- Page 223 and 224:
C'. I~~I~~~~IIIII~~O~,~~~~~~ R6+ 4,
- Page 225 and 226:
'lstrr,tb~xr 171 i?lYJ?I 127 /.IS I
- Page 227 and 228:
S.tlc. S.. ?IXII. Mubuli~r bioluyy
- Page 229 and 230:
(I't,l:~t~cl 211x1 Kin~hronglt IVX4
- Page 231 and 232:
t11.3. Wal 01 TCDD on !he acttnly o
- Page 233:
IIR h r k a ~ r Ilw ~ ;njllmr~ l ~
- Page 239 and 240:
C L m r ~ n . l l ~ T a d ~ 1 6 W J
- Page 241 and 242:
c urbmwen&n= s a( I n.pradpradpradn
- Page 243 and 244:
- aaarslu30 ,.*mra. L~jl;lr; -P4-w~
- Page 245 and 246:
(=I 23. w- C Olln (LC W W. Ubrth d-
- Page 247 and 248:
continuous exposure of humans to in
- Page 249 and 250:
pH 7.6). I00 pl of 200 mM NADPH, IW
- Page 252 and 253:
ioavaiiability andlor production of
- Page 254:
Glutnchlone irrox$dssc, rupcioridc