ON TESTIS AND EPlDlDYMlS OF RATS - Pondicherry University ...

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Table 15. Effect of TCDD on the levels of antioxidants in the caput, corpus and cauda epididymides of adult rats TCDDJ Kg body weight Control I ng 10 ng 100 ng Capur epididymis Glutathione* 143 f 6.83 127 r 8.11. 121 t 4.21. 116 r 3.98. a-Tocopherolb 0.84i 0.06 0.71 f 0.12: 0.70+ 0.16. 0.69i 0.09. Corpus epidrdymb Glutathione' 140 i 7.23 120 t 6.26* 117 c 6.93' 113 i 4.90' a-Tocopherolb 0.82 i 0.1 1 0.74 + 0.06* 0.72 f 0.08' 0.70 t 0.06' " nmoll min/ mg protein; pmol/ min/ mg protein 'I'he data are expressed as nieanfSD for six aninlalsl dosc *p
Tablel6a. Effect of TCDD on the antioxidant enzymes and lipid peroxidation in the caput cpididymis TCDD/ Kg body weight Control 1 ng 10 ny 100 ng Supcroxide disrnutase' 31.98 f 2.18 26.00 f 1.85' 20.13 f 1.57' 17.97 i 2.29' catalaseb 5.18f0.61 4.07+0.21* 3.78f 0.22- 3.65+0.27' Glutathionc reductasen 39.91 f 2.99 28.34 + 1.68' 23.22 + 1.93* 21.33 f 4.41' Glutathione pcroxidase'61.43 f 3.61 40.05 f 2.38. 30.87 + 1 .45* 27.07 2 3.40* Lipid peroxidation' 2.45 i 0.13 3.05 2 0.27. 4.02 * 0.25. 7.56 + 0.76* " nmoll mid mg protein; pmoll rnin / mg protein; ' bmol/ mg protein The data arc expressed as meaniSD for six animals/ dose *pcO.05 against the control group Table 16b. Effect of TCDD on the antioxidant enzymes and lipid peroxidation in the corpus cpididy~nis TCDDi Kg body weight Supcroxide disrnutase' 41.06 i 2.44 33.14 + 2.44' 30.39 f 1.8 1 * 24.23k 3.68' Catalaseb 4.1 7 f 0.31 3.80 f 0.29' 3.43 i 0.35. 3.21f 0.34* Glutathione rcductasea 37.48 i 2.40 30.08 + 2.17' 27.50 f 2.63. 23.88f 5.13' Glutathione pcroxidase'73.22 f 5.82 52.12 f 4.08. 44.94 + 4.66. 36.47i 6.86* Lipid peroxidation' 1.91 * 0.18 2.82 f 0.34. 3.34 i 0.37. 4.88~ 0.52' nmoll mid mg protein; pol/ min I mg protein; ' pmol/ rng protein Thc data arc expressed as rncanfSD for six animals/ dose *p
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FUNCTIONAL STUDIES ON THE EFFECTS O
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ACKNOWLEDGEMENTS I wish to express
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TABLE OF CONTENTS Page No ACKNOWLED
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TABLE OF CONTENTS (Continued) Deter
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TABLE OF CONTENTS (Continued) Effec
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TAULIC OF CON'I'ISN'I'S (C'untinued
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xi LIST OF TABLES (Continued) I'agc
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Table 24a Table 24b Table 24c Table
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Fig. 1 Fig. 2 Effect of TCDD on the
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Fig. 12c Fig. 12d Fig. 13 Fig. 14a
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LIST OF FIGURES (Continued) Fig. 23
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LH M PL mg mRNA N AD NADH NADP NADP
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layers, an outer layer of visceral
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tubular epithelium and continually
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lmn~unization of monkeys against FS
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and this reaction is catalyzed by t
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extratubular environment or synthes
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the most active in protein secretio
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1958). A rapid fall in serum testos
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have also been reported in the rats
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Effect of TCDD on heart muscle has
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1.4 Effect of oxidative stress on m
Page 45 and 46: 2 SCOPE OF THE PRESENT STUDY There
Page 47 and 48: 3 MATERIALS AND METHODS 3.1 Animals
Page 49 and 50: Subgroup III: Administration of TCD
Page 51 and 52: choppcd with the help of sharp razo
Page 53 and 54: anti-FSH antibody. After incubation
Page 55 and 56: lust sped (500 to 700 rpm) on an or
Page 57 and 58: 3.13.4 Quantitative determinntiun u
Page 59 and 60: The plates were dried by inverting
Page 61 and 62: centrifuged at 3,500 g for I5 min o
Page 63 and 64: 3.17 Preparation of tiasue humogena
Page 65 and 66: supcrnutant was taken. Hlunk was pr
Page 67 and 68: 3.21.4 Assay of glutathione peroxid
Page 69: 4 RESULTS 4.1 Administration of TCD
Page 72 and 73: seminiferous tubules was found to b
Page 74 and 75: fractions of rat testis as compared
Page 76 and 77: 4.1.11.1 Effect of TCDD on the prod
Page 78 and 79: 4.2 Co-administration of TCDD and v
Page 80 and 81: 4.2.8 Effect of co-administration o
Page 82 and 83: 4.2.11.5 Effect of co-administratio
Page 84 and 85: Table I b. Effect of TCDD on the we
Page 86 and 87: Table 4. Effect of TCDD on the seru
Page 88 and 89: Table 7b. Effect of TCDD on the pro
Page 90 and 91: Table 8c. Effect of TCDD on the lev
Page 92 and 93: Table 9d. Effect of TCDD on the act
Page 94 and 95: Table 13. Effect of TCDD on the ant
Page 98 and 99: Table 16c. Effcct of TCDD on the an
Page 100 and 101: Table 18a. Effect of co-administrat
Page 103 and 104: Table 21. Effect of co-administrati
Page 105 and 106: Table 24b. Effect of co-administrat
Page 107 and 108: Table 25c. Effect of co-administrat
Page 109 and 110: Table 26d. Effect of co-administrat
Page 111 and 112: Table 30. Effect of co-administrati
Page 113 and 114: Table 32. Effect of caadrninistrati
Page 115 and 116: Table 33c. Effcct of co-administrut
Page 117 and 118: 5 DISCUSSION 5.1 Significance of th
Page 119 and 120: Measurement of weights of the acces
Page 121 and 122: compartment of the cells (Chainy el
Page 123 and 124: the reduction in daily sperm produc
Page 125 and 126: eported in the TCDD-treated rats (M
Page 127 and 128: lilnction is to ililcrccpt lipid pc
Page 129 and 130: in the animals administered with TC
Page 131 and 132: protective effects on serum testost
Page 133: suygcstccl that vivamin 1: conld im
Page 136 and 137: Fig.4~. ENect of TCDD or TCDD and v
Page 138: tE W d In w it I I (,OCX) 3s PUB (,
Page 142 and 143: Fig. 7c. Effect of TCDD or TCDD and
Page 145 and 146: u 3 f ~ = m w * N O .- ~Slew aew en
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Fig.lOb. ENmt of TCDD or TCDD and v
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Fig. 1Ir Effect of TCDD or TCDD md
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Fig. 14c. Effect of TCDD or TCDD an
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Fig. 16b. Effect of TCDD or TCDD an
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Fig.18~. EKect of TCDD or TCDD and
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1 1.2 l4 Fig. 19b. ENect of TCDD or
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Fig. ZOb. Elkt of TCDD or TCDD and
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Fig. 21. Effect olTCDD or TCDD and
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Fig. 22c. Effect of TCDD or TCDD an
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Fig. 24b. Eflect ofTCDD or TCDD and
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7 REFERENCES Aitken RJ, Irvine DS,
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Chitm KC, Latchoumycandanc,C, Mathu
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Flsher JS, Turner KJ, Brown D, Shar
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Hornsby PJ. Regulation of cytochrom
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Latcboumycandane C, Chitra KC, Math
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Moore RW, Panona JA, Bookstaff RC,
Page 189 and 190:
Rommerts FFG, Cooke BA, Van Der Kem
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Slaunwhite WR, Burgett MJ. h virro
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1.1 Preparation of dosing solution
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1.4.6 Wash concentrate One bottle,
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1.7.3 Estradiol controls Two vials.
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1.1 1.2 Orcinol(6%) 6 g of orcinol
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1.16.2 Horseradish peroxidase (8 Un
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1.20 Superoxide dismutase 1.20.1 Tr
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1.24.2 Thiobarbituric acid (TBA; 0.
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Chronic effect: of enclosulfan on t
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enbw1h1.W mu IUY Wcab unpiliml~t at
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cbniuis 11~11 b"nci:~lc ~wlive oxyg
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DNA, RNA ;uxl Wcin wcrr abarval, wh
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Mt~~m(10-lZsu&)vacob- Wfmn Ihehml ~
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New Delhi, llrliil Ib SCI~KK Rcm& M
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tiii~lc rcprmluction or rut (Cllitr
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wciglit (b.wt.) per day for 45 days
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0.1 00 01 " 0.8 I . .lo Dl* rcnn IW
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Chilr:~. K.C.. L!olnn!myci!~dum. C.
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C. hteboumyeradlos . KC. CMtn . P.P
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I. 1 Ilal 01 2 1.7 # I c I ~ ~ L I
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Fin. L Corrclatwn bclwfcn "perm cou
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Iionshii nepmdvctivc mxicity ad upt
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o. Glutathione reductage mg pmWn mg
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IOWAME -. Tor. #558517 PME: 9 SESS:
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JOBNAME: Rqm. Tm. M5W7 PAOB: 11 SBS
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t 02 ELSEVIER Toricology OM) (2W1)
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---- - wcre obtu~ncd from E-Monk. G
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3.2. A,III~AILNI syrlo~t of ,nIroch
Page 253 and 254:
Uc,#!dy. SC. N;tdcru. S , 1% Conlrb
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