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Pandemic Influenza Plan - Questar III

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Section 7: Antiviral Medication Procurement, Distribution, and Use<br />

• Treatment (For clinical guidelines regarding the use of antiviral medications to<br />

treat patients ill with influenza, see Section 5.)<br />

<strong>Plan</strong>ning Considerations<br />

o The effectiveness of antivirals against a new pandemic influenza strain<br />

cannot be predicted.<br />

o Early treatment is a more efficient use of antivirals than prophylaxis,<br />

because prophylaxis requires 6 or more weeks of daily use, instead of a 5-<br />

day treatment course.<br />

o The choice of antiviral medication used will depend on what is known<br />

about the viral resistance pattern and the availability of a particular drug.<br />

o For more information, see Appendix 7-A: Characteristics of Anti-<br />

<strong>Influenza</strong> Antiviral Medications, and Appendix 7-B: Recommended Daily<br />

Dosage of Antiviral Medications for Treatment and Prophylaxis.<br />

Treatment of <strong>Influenza</strong> Disease<br />

The clinical effectiveness of antiviral medications for treatment of novel influenza<br />

is unknown, but it is likely that the earlier treatment is initiated, the greater<br />

likelihood of benefit. Treatment strategies for optimizing the use of limited<br />

stocks of antiviral drugs will vary depending on the phase of the pandemic. As<br />

infection with the pandemic strain becomes more common, laboratory<br />

confirmation will be less necessary to initiate treatment. Strategies include:<br />

At all stages of a pandemic:<br />

o Targeting treatment to influenza patients admitted to the hospital within 48<br />

hours of symptom onset. Treatment after 48 hours of onset may have no<br />

benefit. Note: there are no data on the effectiveness of treatment at<br />

hospitalization. If stockpiled antiviral drug supplies are very limited, the<br />

priority of this group could be reconsidered based on the epidemiology of the<br />

pandemic and any additional data on effectiveness in this population.<br />

o Implementing mechanisms to detect the emergence of drug-resistant variants<br />

by obtaining specimens from persons who develop influenza while on<br />

prophylaxis or who progress in severity despite treatment.<br />

When pandemic influenza is reported abroad, or sporadic pandemic<br />

influenza cases are reported in the United States, without evidence of spread:<br />

o Treatment decisions should be based on laboratory confirmation of disease<br />

caused by the pandemic strain by viral isolation, real-time polymerase chain<br />

reaction (RT-PCR), or other means recommended by CDC. Treatment may be<br />

initiated with a positive rapid antigen test for influenza A, though a<br />

confirmatory test should be performed and treatment discontinued if influenza<br />

is not confirmed (see Sections 2 and 5).<br />

o Negative test results would permit cessation of treatment, given the overall<br />

low rate of infection in a particular location.<br />

February 7, 2006 7-4

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