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Pandemic Influenza Plan - Questar III

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Appendix 7-A<br />

Characteristics of Anti-<strong>Influenza</strong> Antiviral Medications<br />

Inhibits Acts on Administration Common Side<br />

Effects<br />

Amantadine M2 ion channel <strong>Influenza</strong> A Oral CNS, GI<br />

Rimantadine M2 ion channel <strong>Influenza</strong> A Oral CNS, GI (less<br />

often than<br />

Amantadine<br />

Oseltamivir Neuraminidase <strong>Influenza</strong> A Oral<br />

GI<br />

and B<br />

Zanamivir Neuraminidase <strong>Influenza</strong> A<br />

and B<br />

Inhaler Bronchospasm<br />

These agents differ in mechanisms of action, pharmacokinetics, FDA-approved<br />

indications, dosages, cost, and potential for emergence of drug resistance (see July 2005<br />

recommendations of the AHIC: http://www.cdc.gov/mmwr/PDF/rr/rr5408.pdf. )<br />

The neuraminidase inhibitors and rimantadine are superior with regard to the frequency<br />

of side effects.<br />

The use of M2 inhibitors, particularly for treatment, is likely to lead to the emergency and<br />

spread of drug-resistant influenza viruses.<br />

(Source: HHS <strong>Pandemic</strong> <strong>Influenza</strong> <strong>Plan</strong>, Part 2-Public Health Guidance<br />

Supplements, Supplement 7)<br />

February 7, 2006

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