BioHPLC Column Selection Guide Cover - Agilent Technologies
BioHPLC Column Selection Guide Cover - Agilent Technologies
BioHPLC Column Selection Guide Cover - Agilent Technologies
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BioPharmaceutical Lifecycle<br />
Reversed-Phase<br />
Ion-Exchange<br />
Size Exclusion<br />
mRP-C18<br />
ZORBAX Prep HT<br />
300Å StableBond<br />
VariTide RPC<br />
PLRP-S 100Å, 300Å,<br />
1000Å, 4000Å<br />
PL-SAX<br />
PL-SCX<br />
ZORBAX GF-250/450<br />
PURIFICATION – PREP HPLC<br />
Purification<br />
<strong>Agilent</strong> has a comprehensive range of silica and polymeric HPLC columns and media designed for<br />
biomolecule purification. There are high efficiency small particle prep columns optimized for the<br />
purification of µg and mg amounts of a biopharmaceutical drug candidate and fully porous bulk<br />
media, to pack development and process columns to purify multiple 100 g, kg and multi-kg of API.<br />
Some columns are specifically designed to address the needs of high efficiency purification,<br />
while other products provide easy scale-up from small particle analytical columns to full scale<br />
API production. Figure 1 shows prep column/media options and the quantity of product that can<br />
be purified.<br />
Discovery<br />
µg mg<br />
high efficiency<br />
Development<br />
Figure 1: <strong>Agilent</strong> columns and media for biomolecule purification – chromatographic type, product family and purification scale.<br />
Production<br />
g kg multi-kg<br />
high throughput<br />
PURIFICATION<br />
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