PCT/1998/43 - World Intellectual Property Organization

43/1998
15000 PCT Gazette - Section I - Gazette du PCT 29 Oct/oct 1998
(31) 60/044,530 (32) 22 Apr/avr 1997
(22.04.1997)
(31) 60/062,649 (32) 22 Oct/oct 1997
(22.10.1997)
(43) 29 Oct/oct 1998 (29.10.1998)
(33) US
(33) US
(51) 6 C07D 211/06, 213/02, 215/02, 239/02, 309/02,
A61K 31/35, 31/44, 31/445, 31/47, 31/505
(54) •
•
CARBOCYCLIC AND HETEROCYCLIC
SUBSTITUTED SEMICARBAZONES AND
THIOSEMICARBAZONES AND THE USE
THEREOF
SEMICARBAZONES ET THIOSEMICARBA-
ZONES CARBOCYCLIQUES ET HETERO-
CYCLIQUES SUBSTITUES ET LEUR UTILI-
SATION
(71) CoCENSYS, INC. [US/US]; 201 Technology
Drive, Irvine, CA 92618 (US).
(for all designated States except / pour tous les États
désignés sauf US)
(72, 75) WANG, Yan [CN/US]; 25 Bearpaw #27C, Irvine,
CA 92604 (US). CAI, Sui, Xiong [CN/US];
12 Salinas, Foothill Ranch, CA 92610 (US). LAN,
Nancy, C. [US/US]; 522 Hermosa Street, Pasadena,
CA 91030 (US). KEANA, John, F., W.
[US/US]; 3854 Onyx Street, Eugene, OR 97405
(US). ILYIN, Victor, I. [RU/US]; 5205 Paloverde
Road, Irvine, CA 92612–4305 (US). WE-
BER, Eckard [US/US]; 1290 Morningside, Laguna
Beach, CA 92651 (US).
(74) ESMOND, Robert, W. et al. / etc.; Sterne, Kessler,
Goldstein & Fox P.L.L.C., Suite 600, 1100 New
York Avenue, N.W., Washington, DC 20005–3934
(US).
(81) AL AM AT AU AZ BA BB BG BR BY CA CH
CN CU CZ DE DK EE ES FI GB GE GH GM GW
HU ID IL IS JP KE KG KP KR KZ LC LK LR
LS LT LU LV MD MG MK MN MW MX NO NZ
PL PT RO RU SD SE SG SI SK SL TJ TM TR
TT UA UG US UZ VN YU ZW; AP (GH GM KE
LS MW SD SZ UG ZW); EA (AM AZ BY KG
KZ MD RU TJ TM); EP (AT BE CH CY DE DK
ES FI FR GB GR IE IT LU MC NL PT SE); OA
(BF BJ CF CG CI CM GA GN ML MR NE SN
TD TG).
Published / Publiée : (c)
(11) WO 98/47870 (13) A1
(21) PCT/US98/06513
(22) 31 Mar/mar 1998 (31.03.1998)
(25) en (26) en
(31) 08/845,565 (32) 24 Apr/avr 1997
(24.04.1997)
(43) 29 Oct/oct 1998 (29.10.1998)
(33) US
(51) 6 C07D 211/46, C07C 69/96, 68/02
(54) • PROCESS FOR THE SYNTHESIS
OF 4–[6–(HEXYLCARBAMOYLOXY)
HEXYLCARBAMOYLOXY]–PIPERIDINE–1–
CARBOXYLIC ACID 4–PHENOXYPHENYL
ESTER
• PROCEDE DE SYNTHESE DU 4–
PHENOXYPHENYLESTER DE L’ACIDE
4–[6–(HEXYLCARBAMOYLOXY)
HEXYLCARBAMOYLOXY]–PIPERIDINE–1–
CARBOXYLIQUE
(71) AMERICAN HOME PRODUCTS CORPORA-
TION [US/US]; Five Giralds Farms, Madison, NJ
07940–0874 (US).
(72) JIRKOVSKY, Ivo; 17 Normandy Village #6, Nanuet,
NY 10954 (US).
(74) ALICE, Ronald, W.; American Home Products
Corporation, One Campus Drive, Parsippany, NJ
07054 (US) et al. / etc.
(81) AL AM AT AU AZ BA BB BG BR BY CA CH
CN CU CZ DE DK EE ES FI GB GE GH HU IL
IS JP KE KG KP KR KZ LC LK LR LS LT LU
LV MD MG MK MN MW MX NO NZ PL PT RO
RU SD SE SG SI SK SL TJ TM TR TT UA UG
UZ VN YU ZW; AP (GH GM KE LS MW SD
SZ UG ZW); EA (AM AZ BY KG KZ MD RU TJ
TM); EP (AT BE CH DE DK ES FI FR GB GR
IE IT LU MC NL PT SE); OA (BF BJ CF CG CI
CM GA GN ML MR NE SN TD TG).
(11) WO 98/47871 (13) A1
(21) PCT/US98/08312
(22) 14 Apr/avr 1998 (14.04.1998)
(25) en (26) en
(31) 60/045,642 (32) 18 Apr/avr 1997 (33) US
(18.04.1997)
(31) 9709686.1 (32) 13 May/mai 1997 (33) GB
(13.05.1997)
(43) 29 Oct/oct 1998 (29.10.1998)
(51) 6 C07D 213/61, 213/50, C07B 43/00, A61K 31/44
(54) • PROCESS FOR MAKING 2–ARYL–3–ARYL–
5–HALO PYRIDINES USEFUL AS COX–2
INHIBITORS
• PROCEDE DE FABRICATION DE 2–ARYL–
3–ARYL–5–HALOPYRIDINES UTILES EN
TANT QU’INHIBITEURS DE COX–2
(71) MERCK & CO., INC. [US/US]; 126 East Lincoln
Avenue, Rahway, NJ 07065 (US).
(for all designated States except / pour tous les États
désignés sauf US)
(72, 75) PYE, Philip, J. [GB/US]; 126 East Lincoln
Avenue, Rahway, NJ 07065 (US). MALIAKAL,
Ashok [US/US]; 126 East Lincoln Avenue, Rahway,
NJ 07065 (US). ROSSEN, Kai [DE/US]; 126
East Lincoln Avenue, Rahway, NJ 07065 (US).
VOLANTE, Ralph, P. [US/US]; 126 East Lincoln
Avenue, Rahway, NJ 07065 (US). SAGER, Jess
[US/US]; 126 East Lincoln Avenue, Rahway, NJ
07065 (US).
(74) MERCK & CO., INC.; 126 East Lincoln Avenue,
Rahway, NJ 07065 (US).
(81) AL AM AU AZ BA BB BG BR BY CA CN CU
CZ EE GE GW HU ID IL IS JP KG KR KZ LC
LK LR LT LV MD MG MK MN MX NO NZ PL
RO RU SG SI SK SL TJ TM TR TT UA US UZ
VN YU; AP (GH GM KE LS MW SD SZ UG
ZW); EA (AM AZ BY KG KZ MD RU TJ TM);
EP (AT BE CH CY DE DK ES FI FR GB GR IE
IT LU MC NL PT SE); OA (BF BJ CF CG CI CM
GA GN ML MR NE SN TD TG).
Published / Publiée : (c)
(11) WO 98/47872 (13) A1
(21) PCT/EP98/02118
(22) 11 Apr/avr 1998 (11.04.1998)
(25) de (26) de
(31) 197 16 984.8 (32) 23 Apr/avr 1997
(23.04.1997)
(33) DE
(43) 29 Oct/oct 1998 (29.10.1998)
(51) 6 C07D 213/75, A61K 31/44
(54) • PROCESS FOR PREPARING PURE FLUPIR-
TIN MALEATE AND ITS MODIFICATION A
• PROCEDE DE PREPARATION DE MALEATE
DE FLUPIRTINE PUR ET DE SA MODIFICA-
TION A
(71) ASTA MEDICA AKTIENGESELLSCHAFT
[DE/DE]; An der Pikardie 10, D–01277 Dresden
(DE).
(72) OLBRICH, Alfred; Sauerbruch–Strasse 13,
D–33790 Halle (DE). EMIG, Peter; Ludwig–Erhard–Strasse
22, D–63486 Bruchköbel
(DE). KUTSCHER, Bernhard; Stresemannstrasse
9, D–63477 Maintal (DE). LANDGRAF,
Karl–Friedrich; Heinrich–Greif–Strasse 37,
D–01217 Dresden (DE). PAULUHN, Siegfried;
Waldparkring 16, D–74731 Walldürn (DE).
STANGE, Hans; Dresdner Strasse 3, D–01587
Riesa (DE).
(81) AU BR CA CN CZ HU IS JP NO PL RU SK; EP
(ATBECHCYDEDKESFIFRGBGRIEIT
LU MC NL PT SE).
Published / Publiée : (c)
(11) WO 98/47873 (13) A1
(21) PCT/JP98/01708
(22) 15 Apr/avr 1998 (15.04.1998)
(25) ja (26) ja
(31) 9/101220 (32) 18 Apr/avr 1997 (33) JP
(18.04.1997)
(43) 29 Oct/oct 1998 (29.10.1998)
(51) 6 C07D 215/22, 491/056
(54) • PROCESS FOR PRODUCING QUINOLONE
DERIVATIVES
• PROCEDE DE PRODUCTION DE DERIVES
DE QUINOLONE
(71) KIRIN BEER KABUSHIKI KAISHA [JP/JP];
10–1, Shinkawa 2–chome, Chuo–ku, Tokyo
104–8288 (JP).
(for all designated States except / pour tous les États
désignés sauf US)
(72, 75) OSAWA, Tatsushi [JP/JP]; Kirin Beer Kabushiki
Kaisha Iyaku Tansaku Kenkyusho, 3,
Miyahara–cho, Takasaki–shi, Gunma 370–1295
(JP). KUBO, Kazuo [JP/JP]; Kirin Beer Kabushiki
Kaisha Iyaku Tansaku Kenkyusho, 3,
Miyahara–cho, Takasaki–shi, Gunma 370–1295
(JP). MUROOKA, Hideko [JP/JP]; Kirin Beer
Kabushiki Kaisha Iyaku Tansaku Kenkyusho, 3,
Miyahara–cho, Takasaki–shi, Gunma 370–1295
(JP). NAKAJIMA, Tatsuo [JP/JP]; Kirin Beer
Kabushiki Kaisha Iyaku Tansaku Kenkyusho,
1001–1, Hagiwara–machi, Takasaki–shi, Gunma
370–0013 (JP).
(74) SATO, Kazuo et al. / etc.; Kyowa Patent & Law
Office, Room 323, Fuji Building, 2–3, Marunouchi
3–chome, Chiyoda–ku, Tokyo 100–0005 (JP).
(81) CN JP KR US; EP (AT BE CH CY DE DK ES FI
FR GB GR IE IT LU MC NL PT SE).
(11) WO 98/47874
(21) PCT/EP98/02267
(13) A1
(22) 15 Apr/avr 1998 (15.04.1998)
(25) en (26) en
(31) 60/044,525 (32) 22 Apr/avr 1997
(22.04.1997)
(33) US
(43) 29 Oct/oct 1998 (29.10.1998)
(51) 6 C07D 215/42, 215/36, 215/22, 215/12, 401/04,
A61K 31/47, 31/495
(54) • CRF ANTAGONISTIC QUINO– AND QUINA-
ZOLINES
• QUINO– ET QUINAZOLINES ANTAGO-
NISTES CRF
(71) JANSSEN PHARMACEUTICA N.V. [BE/BE];
Turnhoutseweg 30, B–2340 Beerse (BE). NEURO-
CRINE BIOSCIENCES INC. [US/US]; 3050
Science Park Road, San Diego, CA 92121–1102
(US).
(for all designated States except / pour tous les États
désignés sauf US)