PCT/1998/43 - World Intellectual Property Organization

43/1998
29 Oct/oct 1998 PCT Gazette - Section I - Gazette du PCT 15001
(72, 75) HUANG, Charles [CN/US]; (US).
WILCOXEN, Keith, M. [US/US]; (US).
CHEN, Chen [CN/US]; (US). HADDACH,
Mustapha [MA/US]; (US). McCARTHY,
James, R. [US/US]; Neurocrine Biosciences
Inc., 3050 Science Park Road, San Diego, CA
92121–1102 (US).
(74) WANTE, Dirk; Janssen Pharmaceutica N.V., Patent
Dept., Turnhoutseweg 30, B–2340 Beerse
(BE).
(81) AL AM AT AU AZ BA BB BG BR BY CA CH
CN CU CZ DE DK EE ES FI GB GE GH GM GW
HU ID IL IS JP KE KG KP KR KZ LC LK LR
LS LT LU LV MD MG MK MN MW MX NO NZ
PL PT RO RU SD SE SG SI SK SL TJ TM TR
TT UA UG US UZ VN YU ZW; AP (GH GM KE
LS MW SD SZ UG ZW); EA (AM AZ BY KG
KZ MD RU TJ TM); EP (AT BE CH CY DE DK
ES FI FR GB GR IE IT LU MC NL PT SE); OA
(BF BJ CF CG CI CM GA GN ML MR NE SN
TD TG).
Published / Publiée : (c)
(11) WO 98/47875 (13) A1
(21) PCT/IB98/00493
(22) 6 Apr/avr 1998 (06.04.1998)
(25) en (26) en
(31) 60/044,690 (32) 18 Apr/avr 1997 (33) US
(18.04.1997)
(43) 29 Oct/oct 1998 (29.10.1998)
(51) 6 C07D 217/02, C07C 233/80, 233/66, 233/75,
233/76, 213/02
(54) • PROCESS AND INTERMEDIATES
FOR THE PREPARATION OF 4’–
TRIFLUOROMETHYL–BIPHENYL–
2–CARBOXYLIC ACID (1,2,3,4–
TETRAHYDRO–ISOQUINOLIN–6–YL)–
AMIDE
• PROCEDE ET INTERMEDIAIRES DE PRE-
PARATION DE 4’–TRIFLUOROMETHYL–
BIPHENYL–2–ACIDE CARBOXYLIQUE
(1,2,3,4–TETRAHYDRO–ISOQUINOLINE–6–
YL)–AMIDE
(71) PFIZER INC. [US/US]; 235 East 42nd Street, New
York, NY 10017 (US).
(for all designated States except / pour tous les États
désignés sauf US)
(72, 75) RAGAN, John, Anthony [US/US]; 1 Lark
Lane, Gales Ferry, CT 06335 (US).
(74) SPIEGEL, Allen, J. et al. / etc.; Pfizer Inc., 235
East 42nd Street, New York, NY 10017 (US).
(81) AL AM AT AU AZ BA BB BG BR BY CA CH
CN CU CZ DE DK EE ES FI GB GE GH HU ID
IL IS JP KE KG KP KR KZ LC LK LR LS LT LU
LV MD MG MK MN MW MX NO NZ PL PT RO
RU SD SE SG SI SK SL TJ TM TR TT UA UG
US UZ VN YU ZW; AP (GH GM KE LS MW SD
SZ UG ZW); EA (AM AZ BY KG KZ MD RU TJ
TM); EP (AT BE CH CY DE DK ES FI FR GB
GR IE IT LU MC NL PT SE); OA (BF BJ CF CG
CI CM GA GN ML MR NE SN TD TG).
(11) WO 98/47876
(21) PCT/EP98/02455
(13) A1
(22) 21 Apr/avr 1998 (21.04.1998)
(25) en (26) en
(31) 97201227.2
(34) NL et al. / etc.
(32) 24 Apr/avr 1997
(24.04.1997)
(33) EP
(43) 29 Oct/oct 1998 (29.10.1998)
(51) 6 C07D 217/22, 495/04, C07K 5/06, 5/02, A61K
31/47, 31/38
(54) •
•
HETEROCYCLIC DERIVATIVES AND
THEIR USE AS ANTITHROMBOTIC
AGENTS
DERIVES HETEROCYCLIQUES ET LEUR
UTILISATION EN TANT QU’AGENTS ANTI-
THROMBOTIQUES
(71) AKZO NOBEL N.V. [NL/NL]; Velperweg 76,
NL–6824 BM Arnhem (NL).
(for all designated States except / pour tous les États
désignés sauf US)
(72, 75) VAN BOECKEL, Constant, Adriaan, Anton
[NL/NL]; Mercuriusstraat 32, NL–5345 LX Oss
(NL). VAN GALEN, Philippus, Johannes, Marie
[NL/NL]; Harnas 43, NL–5346 WR Oss (NL).
REWINKEL, Johannes, Bernardus, Maria
[NL/NL]; Bram van de Berghstraat 23, NL–5348
JT Oss (NL).
(74) HOGENBIRK, M.; P.O. Box 20, NL–5340 BH
Oss (NL).
(81) AM AU BB BG BR CA CN CZ EE GE HU ID IS
JP KG KP KR LK LR LT LV MD MG MN MX
NO NZ PL RO RU SG SI SK TR TT UA US UZ
VN; AP (GH GM KE LS MW SD SZ UG ZW);
EA (AM AZ BY KG KZ MD RU TJ TM); EP (AT
BE CH CY DE DK ES FI FR GB GR IE IT LU
MC NL PT SE); OA (BF BJ CF CG CI CM GA
GN ML MR NE SN TD TG).
Published / Publiée : (c)
(11) WO 98/47877 (13) A1
(21) PCT/EP98/02244
(22) 20 Apr/avr 1998 (20.04.1998)
(25) en (26) en
(31) 9708119.4 (32) 22 Apr/avr 1997
(22.04.1997)
(43) 29 Oct/oct 1998 (29.10.1998)
(51) 6 C07D 217/26, A61K 31/47, C07D 405/06,
405/12
(33) GB
(54) • 2–BENZOYL–1,2,3,4–
TETRAHYDROISOQUINOLINE–3–
CARBOXAMIDE DERIVATIVES AND
THEIR USE AS INHIBITORS OF HEPATIC
PRODUCTION OF APOB–100
• DERIVES 2–BENZOYL–1,2,3,4–
TETRAHYDRO–ISOQUINOLINE–3–
CARBOXAMIDE ET LEUR UTILISATION
COMME INHIBITEURS DE PRODUCTION
HEPATIQUE DE APOB–100
(71) GLAXO GROUP LIMITED [GB/GB]; Glaxo
Wellcome House, Berkeley Avenue, Greenford,
Middlesex UB6 0NN (GB).
(for all designated States except / pour tous les États
désignés sauf US)
(72, 75) DAUGAN, Alain, Claude–Marie [FR/FR];
Laboratoires Glaxo, Centre de Recherches, Z.A. de
Courtaboeuf, 25, avenue de Québec, F–91940 Les
Ulis (FR). PIANETTI, Pascal, Maurice, Charles
[FR/US]; Glaxo Wellcome Inc., Five Moore Drive,
Research Triangle Park, NC 27709 (US).
(74) LEAROYD, Stephanie, Anne; Glaxo Wellcome
plc, Glaxo Wellcome House, Berkeley Avenue,
Greenford, Middlesex UB6 0NN (GB).
(81) AL AM AT AU AZ BA BB BG BR BY CA CH
CN CU CZ DE DK EE ES FI GB GE GH GM GW
HU ID IL IS JP KE KG KP KR KZ LC LK LR
LS LT LU LV MD MG MK MN MW MX NO NZ
PL PT RO RU SD SE SG SI SK SL TJ TM TR
TT UA UG US UZ VN YU ZW; AP (GH GM KE
LS MW SD SZ UG ZW); EA (AM AZ BY KG
KZ MD RU TJ TM); EP (AT BE CH CY DE DK
ES FI FR GB GR IE IT LU MC NL PT SE); OA
(BF BJ CF CG CI CM GA GN ML MR NE SN
TD TG).
Published / Publiée : (c)
(11) WO 98/47878
(21) PCT/US98/07966
(13) A1
(22) 20 Apr/avr 1998 (20.04.1998)
(25) en (26) en
(31) 08/844,475 (32) 18 Apr/avr 1997
(18.04.1997)
(33) US
(43) 29 Oct/oct 1998 (29.10.1998)
(51) 6 C07D 241/44
(54) • A PROCESS FOR THE PREPARATION OF
HIGHLY PURE 6,7–DICHLORO–5– NITRO–
2,3–DIHYDROQUINOXALINE–2,3–DIONE
•
PROCEDE DE PREPARATION DE
6,7–DICHLORO–5– NITRO–2,3–
DIHYDROQUINOXALINE–2,3–DIONE DE
HAUTE PURETE
(71) ABBOTT LABORATORIES [US/US];
CHAD/377/AP6D–2, 100 Abbott Park Road,
Abbott Park, IL 60064–3500 (US).
(72) GAEDE, Bruce; Apartment 2, 342 Custer Avenue,
Evanston, IL 60202 (US).
(74) STEELE, Gregory, W.; Abbott Laboratories,
CHAD/377/AP6D–2, 100 Abbott Park Road,
Abbott Park, IL 60064–3500 (US).
(81) CA JP MX; EP (AT BE CH CY DE DK ES FI FR
GB GR IE IT LU MC NL PT SE).
(11) WO 98/47879 (13) A1
(21) PCT/DK98/00162
(22) 21 Apr/avr 1998 (21.04.1998)
(25) en (26) en
(31) 0452/97 (32) 22 Apr/avr 1997 (33) DK
(22.04.1997)
(43) 29 Oct/oct 1998 (29.10.1998)
(51) 6 C07D 257/04, 249/12, 271/10, 401/10, 405/10,
409/10, A61K 31/41
(54) • SUBSTITUTED PHENYL DERIVATIVES,
THEIR PREPARATION AND USE
• DERIVES DE PHENYLE SUBSTITUE, LEUR
PREPARATION ET LEUR UTILISATION
(71) NEUROSEARCH A/S [DK/DK]; Smedeland 26
B, DK–2600 Glostrup (DK).
(for all designated States except / pour tous les États
désignés sauf US)
(72, 75) CHRISTOPHERSEN, Palle [DK/DK];
NeuroSearch a/s, Smedeland 26 B, DK–2600
Glostrup (DK). PEDERSEN, Ove [DK/DK];
NeuroSearch a/s, Smedeland 26 B, DK–2600
Glostrup (DK).
(74) NEUROSEARCH A/S; Smedeland 26 B,
DK–2600 Glostrup (DK).
(81) AL AM AT AU AZ BA BB BG BR BY CA CH
CN CU CZ DE DK EE ES FI GB GE GH GM GW
HU ID IL IS JP KE KG KP KR KZ LC LK LR
LS LT LU LV MD MG MK MN MW MX NO NZ
PL PT RO RU SD SE SG SI SK SL TJ TM TR
TT UA UG US UZ VN YU ZW; AP (GH GM KE
LS MW SD SZ UG ZW); EA (AM AZ BY KG
KZ MD RU TJ TM); EP (AT BE CH CY DE DK
ES FI FR GB GR IE IT LU MC NL PT SE); OA
(BF BJ CF CG CI CM GA GN ML MR NE SN
TD TG).
Published / Publiée : (c)
(11) WO 98/47880 (13) A1
(21) PCT/JP98/01770
(22) 17 Apr/avr 1998 (17.04.1998)