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Tratamiento antirretroviral de la infección por el VIH - libdoc.who.int

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97<br />

Qué TARV iniciar<br />

Autores: George Rutherford, Alicen Spaulding<br />

Fecha: 8 Oct 2009<br />

Pregunta: ¿Debe utilizarse EFV o NVP en <strong>el</strong> TARV inicial? (ECAs)<br />

Entornos: Multiples entornos<br />

Bibliografía: 1. Aya<strong>la</strong> Gaytan JJ, <strong>de</strong> <strong>la</strong> Garza ERZ, Garcia MC, Chavez SBV. Nevirapine or efavirenz in combination with two<br />

nucleosi<strong>de</strong> analogues in HIV infected antiretroviral naive patients. Med Intern Mex 2004;20:24. 2. Manosuthi W,<br />

Sungkanuparph S, Tantanathip P, Lueangniyomkul A, Mankatitham W, Prasithsirskul W, Buraptarawong S, Thongyen<br />

S, Likanonsakul S, Thawornwa U, Prommool V, Kuxrungtham K, 2NR Study Team. A randomized trial comparing<br />

p<strong>la</strong>sma drug concentrations and efficacies between 2 nonnucleosi<strong>de</strong> reverse-transcriptase inhibitor-based regimens<br />

in HIV-infected patients receiving rifampicin: the N2R Study. Clin Infect Dis 2009;48:1752-9. 3. Núñez M, Soriano V,<br />

Martín-Carbonero L, Barrios A, Barreiro P, B<strong>la</strong>nco F, García-Benayas T, González-Lahoz J. SENC (Spanish Efavirenz<br />

vs. Nevirapine Comparison) trial: a randomized, open-<strong>la</strong>b<strong>el</strong> study in HIV-infected naive individuals. HIV Clin Trials<br />

2002;3:186-94. 4. Sow PG, Badiane M, Diallo PD, Lo I, Ndiaye B, Gaye AM. Efficacy and safety of <strong>la</strong>mivudine +<br />

zidovudine + efavirenz and <strong>la</strong>mivudine + zidovudine + névirapine in treatment HIV1 infected patients. A rétrospective<br />

cross study analysis [Abstract CDB0584]. XVI International AIDS Conference, Toronto, Canada, 13−18 August 2006. 5.<br />

van <strong>de</strong>n Berg-Wolf M, Hullsiek KH, Peng G, Kozal MJ, Novak RM, Chen L, Crane LR, Macarthur RD; CPCRA 058 Study<br />

Team, the Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA), and The International Network for<br />

Strategic Initiative in Global HIV Trials (INSIGHT). Virologic, immunologic, clinical, safety, and resistance outcomes<br />

from a long-term comparison of efavirenz-based versus nevirapine-based antiretroviral regimens as initial therapy in<br />

HIV-1-infected persons. HIV Clin Trials 2008;9:324-36. 6. van Leth F, Kapp<strong>el</strong>hoff BS, Johnson D, Losso MH, Boron-<br />

Kaczmarska A, Saag MS, Hall DB, Leith J, Huitema AD, Wit FW, B<strong>el</strong>jnen JH, Lange JM; 2NN Study Group.<br />

Pharmacokinetic parameters of nevirapine and efavirenz in re<strong>la</strong>tion to antiretroviral efficacy. AIDS Res Hum Retroviruses<br />

2006;22:232-39.

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