Tratamiento antirretroviral de la infección por el VIH - libdoc.who.int
Tratamiento antirretroviral de la infección por el VIH - libdoc.who.int
Tratamiento antirretroviral de la infección por el VIH - libdoc.who.int
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111<br />
Autores: George Rutherford, Alicen Spaulding<br />
Fecha: 8 Oct 2009<br />
Pregunta: ¿Debe utilizarse AZT o d4T en <strong>el</strong> TARV inicial? (Estudios observacionales)<br />
Entornos: Multiples entornos<br />
Bibliografía: 1. George C, Yesoda A, Jayakumar B, Lal L. A prospective study evaluating clinical outcomes and costs of three<br />
NNRTI-based HAART regimens in Kera<strong>la</strong>, India. J Clin Pharm Ther 2009;34:33-40. 2. Laurent C, Bourgeois A, Mpoudi-<br />
Ngolé E, Ciaffi L, Kouanfack C, Mougnutou R, Nkoué N, Calmy A, Koul<strong>la</strong>-Shiro S, De<strong>la</strong><strong>por</strong>te E. Tolerability and<br />
effectiveness of first-line regimens combining nevirapine and <strong>la</strong>mivudine plus zidovudine or stavudine in Cameroon.<br />
AIDS Res Hum Retroviruses 2008;24:393-9. 3. Mocroft A, Phillips AN, Le<strong>de</strong>rgerber B, Kat<strong>la</strong>ma C, Chiesi A, Goeb<strong>el</strong> FD,<br />
Knysz B, Antunes F, Reiss P, Lundgren JD. Re<strong>la</strong>tionship between antiretrovirals used as part of a cART régimen and<br />
CD4 c<strong>el</strong>l count increases in patients with suppressed viremia. AIDS 2006;20:1141-50. 4. Njoroge J, Reidy W, John-<br />
Stewart G, Attwa M, Kiguru J, Ngumo R, Wambua N, Chung MH. Inci<strong>de</strong>nce of peripheral neuropathy among patients<br />
receiving HAART regimens containing stavudine vs. zidovudine in Kenya [Abstract TUPEB179]. 5th Conference on HIV<br />
Pathogenesis and Treatment and Prevention, Cape Town, South Africa, 19−22 July 2009. 5. Pazare AR, Khirsagar N,<br />
Gogatay N, Bajpai S. Comparative study of inci<strong>de</strong>nce of hyper<strong>la</strong>ctetemia/ <strong>la</strong>ctic acidosis in stavudine vs. AZT based<br />
regime [Abstract THPE0159]. XVII International AIDS Conference, Mexico City, Mexico, 3−8 August 2008.<br />
Evaluación <strong>de</strong> calidad<br />
N° <strong>de</strong><br />
estudios<br />
Diseño<br />
Limitaciones<br />
Mortalidad (observacional)<br />
1 Estudio<br />
observacional<br />
Sin<br />
limitaciones<br />
im<strong>por</strong>tantes<br />
Inconsistencia<br />
Sin<br />
inconsistencias<br />
im<strong>por</strong>tantes<br />
Incertidumbre<br />
<strong>por</strong><br />
evi<strong>de</strong>ncia<br />
indirecta<br />
Imprecisiones<br />
No grave im<strong>por</strong>tantes<br />
4<br />
Otros<br />
factores a<br />
consi<strong>de</strong>rar<br />
Ninguno<br />
Resumen <strong>de</strong> hal<strong>la</strong>zgos<br />
N° <strong>de</strong> pacientes Efecto<br />
AZT d4T<br />
8/85 (9.4%)<br />
11/84<br />
(13.1%)<br />
Re<strong>la</strong>tivo<br />
(IC <strong>de</strong>l<br />
95%)<br />
RR 0.72<br />
(0.3 a 1.7)<br />
Absoluto<br />
37 menos<br />
<strong>por</strong> 1000<br />
(<strong>de</strong> 92<br />
menos a 92<br />
más)<br />
Calidad<br />
⊕⊕OO<br />
BAJA<br />
Im<strong>por</strong>tancia<br />
CRÍTICA
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