Epidemiologia clinicaCentro <strong>di</strong> Riferimento per l'Epidemiologia e la Prevenzione Oncologica in PiemonteScheda: 5.016• Analisi <strong>di</strong> stu<strong>di</strong> conclusi e collaborazione alla preparazione <strong>di</strong> articoli scientifici e partecipazioni acongressi• Pubblicazione dei risultati <strong>di</strong> alcuni stu<strong>di</strong> già conclusi.Da quando è stato avviato, il centro ha collaborato alla progettazione o realizzazione <strong>di</strong> circa 150stu<strong>di</strong>, prevalentemente in campo oncologico ed ematologico.Nel corso del 2011 il centro ha rafforzato la collaborazione con il network italiano <strong>di</strong> ematologimaggiormente attivo nella ricerca sui linfomi (FIL, Fondazione Italiana Linfomi) e con il networkItaliano per lo stu<strong>di</strong>o delle Mielo<strong>di</strong>splasie.COLLABORATORI INTERNI:Ileana BALDI, Francesco BRUNETTI, Ugo CASALONE, Anna CASTIGLIONE, Manuela CECCARELLI,Andrea EVANGELISTA, Franco MERLETTI, Monica MICHELIS, Chiara MONAGHEDDU, Eva PAGANO,Antonio PONTI, Rosalba ROSATO, Fabio SACCONA, Silvano STRALLACOLLABORATORI ESTERNI:Clau<strong>di</strong>a Filippini, Alfredo Berruti, Oscar Bertetto.RISORSE E FINANZIAMENTO:La fase sperimentale <strong>di</strong> avvio del centro ha ricevuto un finanziamento dalla Compagnia <strong>di</strong> SanPaolo nell'ambito del Progetto Oncologia e del finanziamento per il Centro Tumori Molinette.PUBBLICAZIONI:• Mongini F, Evangelista A, Milani C, Ferrero L, Ciccone G, Ugolini A, Pie<strong>di</strong>monte A, Sigaudo M, Carlino E,Banzatti E, Galassi C. An educational and physical program to reduce headache, neck/shoulder pain in aworking community: a cluster-randomized controlled trial. PLoS One <strong>2012</strong>;7:e29637.• Fagà E, De Cento M, Giordanino C, Barletti C, Bruno M, Carucci P, De Angelis C, Venon WD, Musso A, ReggioD, Fagoonee S, Pellicano R, Ceretto S, Ciccone G, Rizzetto M, Saracco G. Safety of propofol in cirrhotic patientsundergoing colonoscopy and endoscopic retrograde cholangiography: results of a prospective controlled study.Eur J Gastroenterol Hepatol <strong>2012</strong>:70-6.• Sanna C, Giordanino C, Giono I, Barletti C, Ferrari A, Recchia S, Reggio D, Repici A, Ricchiuti A, Salizzoni M,Bal<strong>di</strong> I, Ciccone G, Rizzetto M, Saracco G. Safety and efficacy of endoscopic retrogradecholangiopancreatography in patients with post-liver transplant biliary complications: results of a cohort studywith long-term follow-up. Gut Liver 2011;5:328-34.• Bo S, Ciccone G, Rosato R, Villois P, Appen<strong>di</strong>no G, Ghigo E, Grassi G. Cancer mortality reduction andmetformin: a retrospective cohort study in type 2 <strong>di</strong>abetic patients. Diabetes Obes Metab <strong>2012</strong>;14:23-9.• Busca A, Cavecchia I, Locatelli F, D'Ar<strong>di</strong>a S, De Rosa FG, Marmont F, Ciccone G, Bal<strong>di</strong> I, Serra R, Gaido E,Falda M. Blood stream infections after allogeneic stem cell transplantation: a single-center experience with theuse of levofloxacin prophylaxis. Transpl Infect Dis <strong>2012</strong>;14:40-8.• Larocca A, Cavallo F, Bringhen S, Di Raimondo F, Falanga A, Evangelista A, Cavalli M, Stanevsky A, Corra<strong>di</strong>niP, Pezzatti S, Patriarca F, Cavo M, Peccatori J, Catalano L, Carella AM, Cafro AM, Siniscalchi A, Crippa C,Petrucci MT, Yehuda DB, Beggiato E, Di Toritto TC, Boccadoro M, Nagler A, Palumbo A. Aspirin or enoxaparinthromboprophylaxis for patients with newly <strong>di</strong>agnosed multiple myeloma treated with lenalidomide. Blood<strong>2012</strong>;119:933-9• Benevolo G, Larocca A, Gentile M, Pregno P, Gay F, Botto B, Frairia C, Evangelista A, Morabito F, BoccadoroM, Vitolo U, Palumbo A. The efficacy and safety of bortezomib and dexamethasone as a maintenance therapyin patients with advanced multiple myeloma who are responsive to salvage bortezomib-containing regimens.Cancer 2011;117:1884-90.• Palumbo A, Cavo M, Bringhen S, Zamagni E, Romano A, Patriarca F, Rossi D, Gentilini F, Crippa C, Galli M,Nozzoli C, Ria R, Marasca R, Montefusco V, Bal<strong>di</strong>ni L, Elice F, Callea V, Pulini S, Carella AM, Zambello R,Benevolo G, Magarotto V, Tacchetti P, Pescosta N, Cellini C, Polloni C, Evangelista A, Caravita T, Morabito F,Offidani M, Tosi P, Boccadoro M. Aspirin, warfarin, or enoxaparin thromboprophylaxis in patients with multiplemyeloma treated with thalidomide: a phase III, open-label, randomized trial. J Clin Oncol 2011;29:986-93.• Bringhen S, Larocca A, Rossi D, Cavalli M, Genuar<strong>di</strong> M, Ria R, Gentili S, Patriarca F, Nozzoli C, Levi A,Guglielmelli T, Benevolo G, Callea V, Rizzo V, Cangialosi C, Musto P, De Rosa L, Liberati AM, Grasso M, FalconeAP, Evangelista A, Cavo M, Gaidano G, Boccadoro M, Palumbo A. Efficacy and safety of once-weeklybortezomib in multiple myeloma patients. Blood 2010;116:4745-53.• Bucca C, Brussino L, Maule MM, Bal<strong>di</strong> I, Guida G, Culla B, Merletti F, Foresi A, Rolla G, Mutani R, Cicolin A.Clinical and functional pre<strong>di</strong>ction of moderate to severe obstructive sleep apnoea. Clin Respir J 2011;5:219-26.• Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Bal<strong>di</strong> I, Balzarotti M, Bottelli C, Conconi A, Gomez H,Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricar<strong>di</strong> U, Storti S, Gospodarowicz MK,Cavalli F, Sarris AH, Zucca E. First-line treatment for primary testicular <strong>di</strong>ffuse large B-cell lymphoma withrituximab-CHOP, CNS prophylaxis, and contralateral testis irra<strong>di</strong>ation: final results of an international phase IItrial. J Clin Oncol 2011;29:2766-72.215
Epidemiologia clinicaCentro <strong>di</strong> Riferimento per l'Epidemiologia e la Prevenzione Oncologica in PiemonteScheda: 5.016• Zohar S, Bal<strong>di</strong> I, Forni G, Merletti F, Masucci G, Gregori D. Planning a Bayesian early-phase phase I/II studyfor human vaccines in HER2 carcinomas. Pharm Stat 2011;10:218-26.• Bo S, Cassader M, Cavallo-Perin P, Durazzo M, Rosato R, Gambino R. The rs553668 polymorphism of theADRA2A gene pre<strong>di</strong>cts the worsening of fasting glucose values in a cohort of subjects without <strong>di</strong>abetes. Apopulation-based study. Diabet Med <strong>2012</strong>;29:549-52.• Gregori D, Petrinco M, Bo S, Desideri A, Merletti F, Pagano E. Regression models for analyzing costs and theirdeterminants in health care: an introductory review. Int J Qual Health Care 2011;23:331-41.• Gregori D, Petrinco M, Bo S, Rosato R, Pagano E, Berchialla P, Merletti F. Using data mining techniques inmonitoring <strong>di</strong>abetes care. The simpler the better? J Med Syst 2011;35:277-81.• Pagano E, De Rota B, Ferrando A, Petrinco M, Merletti F, Gregori D. An economic evaluation of water birth:the cost-effectiveness of mother well-being. J Eval Clin Pract 2010;16:916-9.• Bigi R, Ferrando A, Pagano E, Cortigiani L, Merletti F, Fiorentini C, Gregori D. Impact of advanced exerciseECG analysis on cost of coronary artery <strong>di</strong>sease management. J Eval Clin Pract 2010;16:678-84.• Gianino MM, Petrinco M, Ferrando A, Galzerano M, Gregori D, Pagano E. [Methodological aspects in valuingloss of production and informal care in cost-of-illness stu<strong>di</strong>es]. Epidemiol Prev 2009;33:243-7.• Palumbo A, Bringhen S, Rossi D, Cavalli M, Larocca A, Ria R, Offidani M, Patriarca F, Nozzoli C, Guglielmelli T,Benevolo G, Callea V, Bal<strong>di</strong>ni L, Morabito F, Grasso M, Leonar<strong>di</strong> G, Rizzo M, Falcone AP, Gottar<strong>di</strong> D, MontefuscoV, Musto P, Petrucci MT, Ciccone G, Boccadoro M. Bortezomib-melphalan-prednisone-thalidomide followed bymaintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initialtreatment of multiple myeloma: a randomized controlled trial. J Clin Oncol 2010;28:5101-9.• Stratta P, Canavese C, Ciccone G, Rosso S. Relative survival of patients with lupus nephritis significantlyimproved over time in an Italian region: comment on the article by Faurschou et al. Arthritis Care Res(Hoboken) 2010;62:1812-3.• Stratta P, Mesiano P, Campo A, Colla L, Fop F, Ciccone G. Atherosclerosis in systemic lupus: the role ofantiphospholipid antibo<strong>di</strong>es needs strict <strong>di</strong>agnostic criteria to be evaluated. Comment on the article by Urowitzet al. Arthritis Care Res (Hoboken) 2011;63:173-4;• Bo S, Ciccone G, Durazzo M, Ghinamo L, Villois P, Canil S, Gambino R, Cassader M, Gentile L, Cavallo-Perin P.Contributors to the obesity and hyperglycemia epidemics. A prospective study in a population-based cohort.Int J Obes (Lond). 2011 Feb 1. [Epub ahead of print] PubMed PMID: 21285941.• Busca A, Locatelli F, Flonta SE, Ciccone G, Bal<strong>di</strong> I, D'Ar<strong>di</strong>a S, Allione B, Falda M. In vivo T-cell depletion withpretransplant low-dose antithymocyte globulin is associated with reduced transplant-related mortality an<strong>di</strong>mprobe clinical outcome in patients receiving allogeneic hematopoietic stem cell transplantation fromunrelated and partially matched related donors. Am J Hematol. 2011 Feb;86(2):214-7. doi: 10.1002/ajh.21907.Epub 2010 Nov 30. PubMed PMID: 21264911.• Giaccone L, Storer B, Patriarca F, Rotta M, Sorasio R, Allione B, Carnevale-Schianca F, Festuccia M, BrunelloL, Omedè P, Bringhen S, Aglietta M, Levis A, Mor<strong>di</strong>ni N, Gallamini A, Fanin R, Massaia M, Palumbo A, Ciccone G,Storb R, Gooley TA, Boccadoro M, Bruno B. Long-term follow up of a comparison of non-myeloablativeallografting with autografting for newly <strong>di</strong>agnosed myeloma. Blood. 2011 Apr 13. [Epub ahead of print]PubMed PMID: 21490341.• Mongini F, Evangelista A, Rota E, Ferrero L, Ugolini A, Milani C, Ceccarelli M, Joffrain L, Ciccone G, Galassi C.Further evidence of the positive effects of an educational and physical program on headache, neck andshoulder pain in a working community. J Headache Pain. 2010 Oct;11(5):409-15. Epub 2010 Jun 20. PubMedPMID: 20563879.• Palumbo A, Bringhen S, Rossi D, Cavalli M, Larocca A, Ria R, Offidani M, Patriarca F, Nozzoli C, Guglielmelli T,Benevolo G, Callea V, Bal<strong>di</strong>ni L, Morabito F, Grasso M, Leonar<strong>di</strong> G, Rizzo M, Falcone AP, Gottar<strong>di</strong> D, MontefuscoV, Musto P, Petrucci MT, Ciccone G, Boccadoro M. Bortezomib-melphalan-prednisone-thalidomide followed bymaintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initialtreatment of multiple myeloma: a randomized controlled trial. J Clin Oncol. 2010 Dec 1;28(34):5101-9.• Rota E, Evangelista A, Ciccone G, Ferrero L, Ugolini A, Milani C, Ceccarelli M, Galassi C, Mongini F.Effectiveness of an educational and physical program in reducing accompanying symptoms in subjects withhead and neck pain: a workplace controlled trial. J Headache Pain. 2011 Jan 20. [Epub ahead of print] PubMedPMID: 21249417.• Palumbo A, Bringhen S, Bruno B, Falcone AP, Liberati AM, Grasso M, Ria R, Pisani F, Cangialosi C, Caravita T,Levi A, Meloni G, Nozza A, Pregno P, Gabbas A, Callea V, Rizzo M, Annino L, De Stefano V, Musto P, Bal<strong>di</strong> I,Cavallo F, Petrucci MT, Massaia M, Boccadoro M. Melphalan 200 mg/m(2) versus melphalan 100 mg/m(2) innewly <strong>di</strong>agnosed myeloma patients: a prospective, multicenter phase 3 study. Blood 2010;115:1873-9.• Fracchia M, Senore C, Armaroli P, Ferraris R, Placido RD, Musso A, Turco D, Bellisario C, Bal<strong>di</strong> I, Segnan N.Assessment of the multiple components of the variability in the adenoma detection rate in sigmoidoscopyscreening, and lessons for training. Endoscopy 2010. [Epub ahead of print] PubMed PMID: 20414864.• Terragni PP, Antonelli M, Fumagalli R, Faggiano C, Berar<strong>di</strong>no M, Pallavicini FB, Miletto A, Mangione S, Sinar<strong>di</strong>AU, Pastorelli M, Vival<strong>di</strong> N, Pasetto A, Della Rocca G, Urbino R, Filippini C, Pagano E, Evangelista A, Ciccone G,Mascia L, Ranieri VM. Early vs late tracheotomy for prevention of pneumonia in mechanically ventilated adultICU patients: a randomized controlled trial. JAMA 2010;303:1483-9.• Berruti A, Bollito E, Cracco CM, Volante M, Ciccone G, Porpiglia F, Papotti M, Scarpa RM, Dogliotti L. Theprognostic role of immunohistochemical chromogranin a expression in prostate cancer patients is significantlymo<strong>di</strong>fied by androgen-deprivation therapy. Prostate 2010;70:718-26.• Bo S, Gambino R, Gentile L, Pagano G, Rosato R, Saracco GM, Cassader M, Durazzo M, Cavallo-Perin P.High-normal blood pressure is associated with a cluster of car<strong>di</strong>ovascular and metabolic risk factors: apopulation-based study. J Hypertens 2009;27:102-8.• Bal<strong>di</strong> I, Maule M, Bigi R, Cortigiani L, Bo S, Gregori D. Some notes on parametric link functions in clinical216