Narcissus and Daffodil

Table 6.4 Continued
Alkaloid Activity References
* Slightly reduces DNA synthesis,
whereas RNA synthesis is
practically unaffected
51 haemanthidine * Analgesic
* Antiinflamatory
* Active against A-431, KB, Lu1,
Me12 and ZR-75-1 cell lines
* Significantly active against
LNCaP and HT cell lines
30 hippeastrine * Antiviral. Active against Herpes
simplex type 1
* Weak insect antifeedant
* Significantly active against the
LNCaP and HT cell lines
* Cytotoxic against non-cancerous
LMTK cells
* Weak cytotoxic against Molt 4
lymphoid cells
23 homolycorine * Inductor of delayed
hypersensitivity in animals
* Cytotoxic against fibroblastic
LMTK cells
24 8-O-demethylhomolycorine
29 9-O-demethyl-
2α- hydroxyhomolycorine
* Cytotoxic against fibroblastic
LMTK cells
* Weak cytotoxic against Molt 4
lymphoid cells
* Cytotoxic against fibroblastic
LMTK cells
* Moderately active against Molt 4
lymphoid cells
67 ismine * Cytotoxic against Molt 4
lymphoid and LMTK
fibroblastic cell lines
77 lycoramine * Central anticholinesterase activity
stronger than galanthamine
* Inhibits the formation of peptide
bond in protein synthesis
* Like neostigmine, antagonizes
muscle paralysis induced by
d-tubocurarine, also antagonizes
the ganglionic blockade, and
increases the contraction
response
* Produces acute poisoning
of digestive, respiratory,
cardiovascular, neuromuscular
and central nervous systems
31 lycorenine * Analgesic
* Weak hypotensive
* Vasodepressor action ascribed to
Antoun et al., 1993
Çitoglu et al., 1998
Tanker et al., 1996
Antoun et al., 1993
Renard-Nozaki et al., 1989
Weniger et al., 1995
Gude et al., 1988
Weniger et al., 1995
Weniger et al., 1995
Weniger et al., 1995
Weniger et al., 1995
Chao et al., 1965
Missoum et al., 1997
Vigneau et al., 1984
Codina et al., 1992b
Ghosal et al., 1985b
Miyasaka and Hiramatsu,
1980