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Narcissus and Daffodil

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CONCLUSIONS<br />

Synthesis of galanthamine 327<br />

A comparative analysis of the known schemes of the total synthesis of galanthamine<br />

has shown that biomimetic methods are preferable over classical synthetic<br />

approaches because they are carried out in the most economical way, with a minimum<br />

of steps, with maximum yields <strong>and</strong> simple realisation. In a single scheme,<br />

the production of different natural members of the galanthamine series is possible.<br />

REFERENCES<br />

Abduazimov, Kh.A. (1993) Alkaloids of Amaryllidaceace plants. In Results of Alkaloid Containing<br />

Plants Study, ‘FAN’, Uzbekian Academy of Sciences, Tashkent, pp. 170–189 (in Russian).<br />

Ackl<strong>and</strong>, D.J. <strong>and</strong> Pinhey, J.T. (1987a) The chemistry of aryl-lead (IV) tricarboxylates.<br />

Reaction with vinylogous β-ketoesters. Journal of the Chemical Society Perkin Transactions I,<br />

No. 12, 2689–2694.<br />

Ackl<strong>and</strong>, D.J. <strong>and</strong> Pinhey, J.T. (1987b) Use of the electrophilic arylation reaction of aryllead<br />

triacetates in a synthesis of (±)-lycoramine. Journal of the Chemical Society Perkin Transactions<br />

I, No. 12, 2695–2700.<br />

Bannister, R.M. <strong>and</strong> McCague, R. (1997) Process for Preparing of Galanthamine <strong>and</strong> its Derivatives.<br />

International Patent Application No. WO 97 11,078 (Chemical Abstracts, 126, 264238).<br />

Barton, D.H.R. <strong>and</strong> Cohen, T. (1957) Some biogenetic aspects of phenol oxidation. In Arbeiten<br />

aus dem Gebiet der Naturstoffchemie, Birkhauser, Basel, pp. 117–143.<br />

Barton, D.H.R. <strong>and</strong> Kirby, G.W. (1960) The synthesis of galanthamine. Proceedings of the<br />

Chemical Society, No. 11, 392–393.<br />

Barton, D.H.R. <strong>and</strong> Kirby, G.W. (1962) Phenol oxidation <strong>and</strong> biosynthesis. V. Synthesis of<br />

galanthamine. Journal of the Chemical Society, No. 2, 806–817.<br />

Barton, D.H.R., Kirby, G.W., Taylor, J.B. <strong>and</strong> Thomas, G.M. (1961) The biosynthesis of<br />

Amaryllidaceae alkaloids. Proceedings of the Chemical Society, No. 7, 254–255.<br />

Barton, D.H.R., Kirby, G.W., Taylor, J.B. <strong>and</strong> Thomas, G.M. (1962) Multiple labeling<br />

experiments in the biosynthesis of Amaryllidaceae alkaloids. Proceedings of the Chemical<br />

Society, No. 5, 159.<br />

Barton, D.H.R., Kirby, G.W., Taylor, J.B. <strong>and</strong> Thomas, G.M. (1963) Phenol oxidation <strong>and</strong><br />

biosynthesis. VI. The biogenesis of Amaryllidaceae alkaloids. Journal of the Chemical Society,<br />

No. 9, 4545–4558.<br />

Bolton, R.E., Moody, C.J., Rees, C.W. <strong>and</strong> Tojo, G. (1987) Vinyl azides occurring phosphodiesterase<br />

inhibitors PDE-I <strong>and</strong> PDE-II. Journal of the Chemical Society Perkin Transactions<br />

I, No. 4, 931–935.<br />

Brossi, A., Gurien, H., Rachlin, A.I. <strong>and</strong> Teitel, S. (1967) Selective demethylation of 3,4dimethoxy-substituted<br />

aromatic aldehydes <strong>and</strong> ketones. Journal of Organic Chemistry, 32<br />

(4), 1269–1270.<br />

Bulavka, V.N. (1993) Galanthamine Syntheses Study. Ph.D. Report, M.V. Lomonosov Moscow<br />

Institute of Fine Chemical Technology, Moscow, 156 pp.; Abstract, 23 pp. (in Russian).<br />

Bulavka, V.N., Shchavlinsky, A.N. <strong>and</strong> Tolkachev, O.N. (1993) Method of 2-(alkoxyphenyl)<br />

ethylamine Production. Soviet Union Patent No. 1,436,454 (in Russian) (Chemical Abstracts,<br />

122, 160263).<br />

Bulavka, V.N., Shchavlinsky, A.N. <strong>and</strong> Tolkachev, O.N. (1994c) Zinc dust as a novel reduction<br />

agent for 2′-nitrostyrenes, formamides <strong>and</strong> acetophenones. In 10th International<br />

Conference on Organic Synthesis, Bangalore, December 1994, Abstract P-WED-70.<br />

Bulavka, V.N., Shchavlinsky, A.N. <strong>and</strong> Tolkachev, O.N. (1999) N-methyltyramine <strong>and</strong> N,Odimethyltyramine<br />

synthesis via intermediate 4-methoxyphenyl-N-methylthioacetamide.

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