Narcissus and Daffodil

Table 6.4 Continued
Alkaloid Activity References
1 lycorine
(contd.)
responsible, at least in part,
for the growth-inhibitory and
cytotoxic effects of lycorine
* Certain bacterias transform
lycorine into pancrassidine
(less cytotoxic than ungeremine)
* The changes observed in
response to stress suggest
its role in protective and repair
mechanisms of producer plants
* Insecticide
* Insect antifeedant
61 3-epimacronine * Weak cytotoxic against human
Molt 4 and murine LMTK cell
lines
Weniger et al., 1995
40 maritidine * Antineoplastic Alarcón et al., 1986
Youssef and Frahm, 1998
27 masonine * Inductor of delayed
hypersensitivity in animals
Gude et al., 1988
82 mesembrenone * Cytotoxic against Molt 4
lymphoid cells
* Weak cytotoxic against
fibroblastic LMTK cells
Weniger et al., 1995
63 narciclasine * Antimitotic and cell growth
inhibitor
* Strong tumour inhibitor.
One of the most important
antineoplastic Amaryllidaceae
alkaloids
* Active against larynx and
cervix carcinomas
* Inhibitor of growth of Ehrlich
tumour cells
* Inhibitor of HeLa cells growth
* No effect has been observed
towards solid tumours
(sarcoma 180)
* Inhibitor of protein synthesis
in eukariotic ribosomes,
blocking the peptide bond
formation on the 60S ribosomal
subunit.
* Resistance to narciclasine in a
mutant strain of Saccharomyces
cerevisiae is due to an alteration
on the peptidyl transferase
centre
* Reduces DNA synthesis, whereas
RNA synthesis is practically
unaffected
* Enhances the uptake of uridine
and stimulates the synthesis of
Abou-Donia et al., 1991
Aller, 1981
Báez and Vázquez, 1978
Bi et al., 1998
Carrasco et al., 1975
Ceriotti et al., 1967
CHCD, 1996
Evidente, 1991
Evidente et al., 1986
Gabrielsen et al., 1992
Ghosal et al., 1989a
Hua et al., 1997
Jiménez et al., 1975a
Jiménez et al., 1975b
Jiménez et al., 1976
Keck and Fleming, 1978
Pettit et al., 1986
Pettit et al., 1993
Pettit et al., 1995a
Pettit et al., 1995b
Rodríguez-Fonseca et al., 1995
Veronese et al., 1991