B O O K - American College of Rheumatology

ACR Clinical Symposium
8:45 - 9:45 am
ACR State-of-the-Art Lecture
8:45 - 9:45 am
wednesday
98
Hall A3
Myositis 2010: A to Z c/r cP P/C PS
Moderator: Chester V. Oddis, MD; University of Pittsburgh;
Pittsburgh, PA
Speaker: Frederick W. Miller, MD, PhD; National Institute of
Environmental Health Sciences, NIH; Kennsington, MD
Session Overview:
Patients with myositis are a diagnostic and therapeutic challenge
for the practicing rheumatologist. ACR members frequently
request updates on the inflammatory myopathies and the
different subsets such as polymyositis, dermatomyositis, overlap
syndromes and inclusion body myositis. This review will focus on
all aspects of myositis including diagnosis, ongoing assessment
and management considerations. The mimics of myositis will
be considered along with the assessment and treatment of the
refractory myositis patient.
Upon completion of this session, participants should be able to:
• identify patients with the various clinical syndromes
associated with the inflammatory myopathies
• outline a diagnostic and therapeutic plan in patients
diagnosed with idiopathic inflammatory myopathy
• identify the mimics of myositis and assess and treat the
patient with refractory disease
ACR Immunology Updates for
Clinicians
8:45 - 9:45 am
Thomas J. Murphy Ballroom
Epigenetics 101 c/r
Moderator: Richard J. Looney, MD; University of Rochester;
Rochester, NY
Speaker: Robert A. Colbert, MD, PhD; NIAMS/NIH; Bethesda, MD
Session Overview:
Epigenetics is the regulation of gene expression without
altering the nucleotide sequence of the genome. Epigenetics
determines gene expression in cellular differentiation, e.g.,
differential cytokine production in T cell subsets, and is involved
in gene silencing including X chromosome inactivation in
females. Epigenetics also explains the pathogenesis of druginduced
lupus. Inhibitors of histone deacetylases target one
mechanism of epigenetic regulation of gene expression. Histone
deacetylases inhibition is being tested in a wide variety of
human malignancies and has shown promise in animal models
of lupus.
Upon completion of this session, participants should be able to:
• describe how different epigenetic mechanisms regulate gene
expression
• describe the important of epigenetics in the
immunopathogenesis of human disease
• discuss potential therapeutic applications of epigenetics
2010 Program Book
B406
From Fat to Joints - The Vicious Side of Adipokines
R
Moderator: David S. Pisetsky, MD, PhD; Duke University Medical
Center; Durham, NC
Speaker: Ulf Muller-Ladner, MD; University Giessen/Kerckhoff-
Clinic; Bad Nauheim, Germany
Session Overview:
Recent studies revealed several links between adipose tissue,
adipocytokines, and arthritis. This presentation will review
the evidence indicating that adipose tissue is not an innocent
bystander tissue and may influence the inflammatory process.
Upon completion of this session, participants should be able to:
• illustrate the variety of adipokines operative in non-metabolic
inflammatory rheumatic diseases
• describe the role of adipokines in inflammatory processes
• visualize the potential of anti-adipokine targeted therapies in
inflammatory conditions
ACR REF Special Session
8:45 - 9:45 am
Sidney J. Marcus Auditorium
REF Paul Klemperer, MD, Memorial Lectureship:
Systemic Sclerosis: Genetic? Autoimmune? One
Disease? c/r
Moderator: E. William St.Clair, MD; Duke University Medical
Center; Durham, NC
Speakers: Frank C. Arnett, MD; University of Texas Medical
School; Houston, TX
Session Overview:
Progressive systemic sclerosis is a devastating disease that
all rheumatologists see regularly. It is essential that clinicians
be familiar with the latest data concerning etiopathogenesis
and disease classification in order to educate their patients
and to manage the disease optimally. This lecture will update
the attendees on current thinking about the genetic basis of
progressive systemic sclerosis and how that relates to diagnosis
and management.
Upon completion of this session, participants should be able to:
• describe the aspects of systemic sclerosis that suggest a
genetic etiology
• review the autoimmune aspects of the disease
• discuss which aspects of the clinical presentation suggest that
there are several underlying disease processes and which
suggest a single unifying etiology
ACR/ARHP Poster Session C and
Poster Tours
9:00 am - 6:00 PM
Halls B1 & B2
Poster presenters will be available from 9:00 - 11:00 am.
Poster tours will be held 9:00 - 9:45 am, 10:15 - 11:00 am
and 4:30 - 5:30 PM.