B O O K - American College of Rheumatology

ACR/ARHP Poster Session C
1509. Role of the Metalloproteinase ADAM-8 in the Regulation of
the Inflammatory Response. PSGL-1 Shedding by ADAM-8
in Human Neutrophils. Maria Jesus Dominguez-Luis 4 , Ana
Urzainqui-Mayayo 1 , Ada Maria Herrera-Garcia 4 , Ana Diaz-
Martin 5 , Maria Teresa Arce-Franco 5 , Faustino Mollinedo 2 ,
Francisco Sanchez-Madrid 1 and Federico Diaz-Gonzalez 3 ,
1
Immunology Service, Hospital de La Princesa, Madrid, Spain,
2
Instituto Superior del Cancer, Salamanca, Spain, 3 Rheumatology
Service, Hospital Universitario de Canarias, La Laguna, Tenerife,
Spain, 4 Rheumatology Service, Hospital Universitario de
Canarias, La Laguna, Spain, 5 Rheumatology Service, Hospital
Universitario de Canarias, Spain.
Cytokines, Mediators, Gene Regulation II
1510. In Vitro Hypoxia-Induced Mitochondrial Genome Mutagenesis
and Dysfunction. Monika Biniecka 2 , Edward Fox 1 , Chin T.
Ng 2 , Wei Gao 2 , Ursula Fearon 2 , Douglas Veale 2 and Jacintha
O’Sullivan 2 , 1 Department of Pathology, University of
Washington, Seattle, WA, 2 Translation Research Group, Dublin
Academic Medical Centre, St. Vincent’s University Hospital,
Dublin, Co. Dublin, Ireland.
1511. Allograft Inflammatory Factor-1 Facilitates the Migration
of Fibroblasts and Has a Correlation with the Pathogensis
of Skin Fibrosis in a Murine Model of a Murine Model of
Sclerodermatous GVHD. Aihiro Yamamoto 1 , Eishi Ashihara 2 ,
Yoko Nakagawa 2 , Hiroshi Obayashi 3 , Takahiro Seno 1 , Masatoshi
Kadoya 1 , Masahide Hamaguchi 1 , Hidetaka Ishino 1 , Masataka
Kohno 1 , Taira Maekawa 2 and Yutaka Kawahito 1 , 1 Department
of Inflammation and Immunology, Graduate School of Medical
Science, Kyoto Prefectural University of Medicine, 2 Department
of Transfusion Medicine and Cell Therapy, Kyoto University
Hospital, 3 Institute of Bio-Response Informatics.
1512. Bach1 Regulates Heme Oxygenase-1 Expression of Human
Monocytes in Response to LPS: Implication in Behcet’s
Disease. Mitsuhiro Takeno, Takuya Miyazaki, Yohei Kirino, Sei
Samukawa, Maasa Hama and Yoshiaki Ishigatsubo, Yokohama
City University Graduate School of Medicine.
1513. BMS-582949 Is a Dual Action p38 Kinase Inhibitor Well Suited
To Avoid Resistance Mechanisms That Increase p38 Activation
in Cells. Gary Schieven 1 , Rosemary Zhang 2 , Sidney Pitt 2 , Ding-
Ren Shen 2 , Jian Cao 2 , John Sack 2 , Arthur Doweyko 2 and Petra
Ross-MacDonald 2 , 1 Bristol-Myers Squibb, Princeton, NJ, 2 Bristol-
Myers Squibb.
1514. Both Insulin Receptor and Nampt Activity Are Implicated
in Visfatin/Nampt Induced PGE2 Synthesis in Articular
Chondrocytes. Marjolaine Gosset 4 , Francis Berenbaum 2 ,
Colette Salvat 4 , Alain Sautet 1 , Martin Holzenberger 3 and Claire
Jacques 4 , 1 Faculty of Medicine P&M Curie, Paris, France, 2 Faculty
of Medicine P&M Curie, UR 4 Paris Universitas, Paris, France,
3
Inserm U 893 , Paris, France, 4 UR 4 Paris Universitas, Paris, France.
1515. Comparison of IL-17F and IL-17A Effects and Signaling in
Human Rheumatoid Arthritis Synoviocytes. Arnaud Hot,
Saloua Zrioual, Anne Tournadre, Vanina Lenief and Pierre
Miossec, Immunogenomics and Inflammation Research Unit
and Department of Immunology and Rheumatology, Hospital
Edouard Herriot, Lyon, France.
1516. Down-Regulation of Pyrin Promotes Up-Regulation of the
Anti-Apoptotic Gene, BCL2, Via the Signal Transducer, gp130,
and Leads to the Activation of the PI3K/Akt Pathway. Geryl M.
Wood 4 , James Balow, Jr 3 , Hong-Wei Sun 2 , Ivona Aksentijevich 3 ,
Jae Jin-Chae 3 , Nitza Shoham 1 and Daniel L. Kastner 3 , 1 Allergy
Immunology Laboratory, Meir Hospital, Kfar-Saba, Israel,
2
Biodata Mining and Discovery, Office of Science and
Technology, National Institutes of Health, NIAMS, 3 Laboratory
of Clinical Investigation, National Institutes of Health, NIAMS,
4
Laboratory of Clinical Investigation, National Institutes of
Health, NIAMS, Bethesda, MD.
1517. Effect of the PEG Component of Certolizumab Pegol on Calcium
Flux in Cellular Systems. Gianluca Fossati 2 and Andrew Nesbitt 1 ,
1
New Medicines, UCB, Slough, Berkshire, United Kingdom, 2 New
Medicines, UCB, Slough, UK.
1518. Expression of the Wnt Inhibitor sFRP-1 in Synovial Fibroblasts
Is Regulated by the Histone Methyltransferase EZH2. Michelle
Trenkmann 1 , Matthias Brock 3 , Renate E. Gay 2 , Christoph Kolling 5 ,
Rudolf Speich 4 , Beat A. Michel 2 , Steffen Gay 2 and Lars C. Huber 3 ,
1
Center of Experimental Rheumatology, University Hospital
Zurich/Zurich Center of Integrative Human Physiology (ZIHP),
Zurich, Switzerland, 2 Center of Experimental Rheumatology,
University Hospital Zurich/Zurich Center of Integrative Human
Physiology (ZIHP), Switzerland, 3 Center of Experimental
Rheumatology, University Hospital Zurich/Zurich Center of
Integrative Human Physiology (ZIHP), Switzerland/Department
of Internal Medicine, University Hospital, Zurich, Switzerland,
4
Department of Internal Medicine, University Hospital Zurich,
Switzerland, 5 Schulthess Clinic, Zurich, Switzerland.
1519. Fms-Like Tyrosine Kinase 3 Ligand (Flt3L) Levels Are Elevated
in Arthritis: Role of Flt3L in Regulating Monocyte Migratory
Pattern in RA. Inês Ramos 2 , Ana Oliveira 3 , Geurt Schilders 3 ,
Saïda Aarrass 3 , Cristina Lebre 3 and Paul P. Tak 1 , 1 Academic Med
Ctr/Univ of Amsterdam, Amsterdam, The Netherlands, 2 Division
of Clinical Immunology and Rheumatology, Academic Medical
Center/University of Amsterdam, Amsterdam, The Netherlands,
3
Division of Clinical Immunology and Rheumatology, Academic
Medical Center/University of Amsterdam, Amsterdam, The
Netherlands.
1520. Functional Expression of CD13/Aminopeptidase N by RA
Synovial Cells In Vitro and In Vivo. Rachel Morgan, Judith
Endres and David A. Fox, University of Michigan.
1521. Gottron’s Papules Exhibit Accumulation of CD44 Variant 7
(CD44v7) and Its Binding Partner Osteopontin: A Unique
Molecular Signature. Jessica Kim 1 and Victoria P. Werth 2 , 1 New
York University School of Medicine, 2 University of Pennsylvania,
Philadelphia, PA.
1522. Identification of the NR4A Family of Orphan Nuclear Receptors
as Mediators of Adenosine A2A Receptor Activation. Jason P.
McMorrow 2 , Evelyn P. Murphy 2 and Bruce N. Cronstein 1 , 1 New
York Univ Med Ctr, New York, NY, 2 University College Dublin,
Dublin, Ireland.
1523. Increased Expression of Acid Sensing Ion Channel (ASIC)
Mediated by ERK/MAPK Pathway in Mouse Anti-Type II
Collagen Antibody-Induced Arthritis. Juyoun Kim 2 , Keon Uk
Park 2 , Jinyeong Chae 3 , Hyun-OK Kim 1 and Sang-Hyon Kim 2 ,
1
Department of Rheumatology, College of Medicine and
Institute of Health Science, Jinju, Korea, Republic of, 2 Keimyung
University Dongsan Medical Center, Daegu, Kungsang Province,
Korea, Republic of, 3 Keimyung University Dongsan Medical
Center, Daegu, Kungsang, Korea, Republic of.
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2010 Program Book