B O O K - American College of Rheumatology

6:45 PM
Macrophage Activation Syndrome in the Adult ICU
Bita Shakoory, MD; University of Alabama-Birmingham;
Birmingham, AL
7:10 PM
Distinguishing Sepsis from MAS
Joseph Carcillo, MD; Children’s Hospital of Pittsburgh; Pittsburgh,
PA
7:35 PM
Infectious Models of MAS
Michael Jordan, MD, PhD; Children’s Hospital Medical Center,
Cincinnati; Cincinnati, OH
Session Overview:
Macrophage activation syndrome is an often lethal entity
associated with a variety of pediatric and adult infectious,
oncologic, rheumatic (lupus, Still disease, vasculitis, etc.),
and primary genetic disorders. Early recognition of MAS and
institution of aggressive immunosuppressive therapy are keys to
optimizing survival. Experts from different medical subspecialties
have different perspectives of this end common pathway of
MAS. Genetic propensities for developing MAS, and animal
models of MAS pathophysiology are being explored. What we
learn about MAS from clinical and scientific experts in nonrheumatic
fields will benefit adult and pediatric rheumatologists
in diagnosing and treating patients who develop MAS.
Upon completion of this session, participants should be able to:
• identify the various infectious triggers of macrophage
activation syndrome
• discuss the diagnostic criteria for macrophage activation
syndrome in the setting of infection
• distinguish sepsis from macrophage activation syndrome
• articulate the proposed pathophysiologic events leading to
macrophage activation syndrome
B311
MRI
Moderator: Mikkel Østergaard, MD, PhD, DMSc; Hvidovre
University Hospital; Hvidovre, Denmark
6:45 PM
MRI of Cartilage in Osteoarthritis and Rheumatoid Arthritis -
Introduction
Mikkel Østergaard, MD, PhD, DMSc; Hvidovre University
Hospital; Hvidovre, Denmark
7:00 PM
Function and Structure of Cartilage in Health and Disease: A
MRI Perspective
Deborah Burstein, PhD; Beth Israel Deaconess Medical Center;
Boston, MA
7:20 PM
What Have We Learned about Cartilage from MRI Studies of
Osteoarthritis and How Can We Get?
To be announced
7:40 PM
Challenges in MRI Assessment of Cartilage in RA and What
Lessons to Learn from Studies in Osteoarthritis
Philip G. Conaghan, MD, PhD; Chapel Allerton Hospital; Leeds,
United Kingdom
Session Overview:
Increasing amounts of data on MRI in arthritides are emerging,
and the technique is increasingly used in clinical trials and
practice, making a forum for update on and discussion of this
topic at ACR very relevant. An ACR study group addressing
different aspects of MRI has existed since 2006, with varying
focus and content. This year it is proposed to focus on “MRI of
cartilage in OA and RA”, and is expected to provide novel insights
on MRI assessment of cartilage involvement in osteoarthritis and
rheumatoid arthritis, and provide an option for crossfertilizatioin
between the OA and RA research areas.
Upon completion of this session, participants should be able to:
• identify the current concepts MRI assessment of function and
structure of cartilage in health and disease
• discuss what has been learnt from MRI studies about cartilage
and non-cartilage structures in osteoarthritis
• describe the challenges of MRI assessment of cartilage in
rheumatoid arthritis and which lessons can be learnt from
MRI studies in osteoarthritis
B308
Neuro Endocrine Immunology
Moderator: Frank Buttgereit, MD; Charite University Med-Berlin;
Berlin, Germany
6:45 PM
The Immunomodulatory Properties of Adipokines and
Adiponectin
Ulf Muller-Ladner, MD; University Giessen/Kerckhoff-Clinic; Bad
Nauheim, Germany
7:05 PM
Knowing the Fat for Fighting Diseases - Leptin: At the Crossroad
of Energy Homeostasis, Immune Response and Systemic
Inflammation
Oreste Gualillo, PharmD, PhD; Santiago University Clinical
Hospital; Santiago de Compostela, Spain
7:25 PM
The Impact of Abnormal Body Composition on Disease Activity
in Rheumatoid Arthritis
Jon T. Giles, MD; Johns Hopkins University; Baltimore, MD
7:45 PM
Panel Discussion
Upon completion of this session, participants should be able to:
• describe how adipokines modulate inflammation in adipose
and mesenchymal tissue
• identify the pathophysiology of white adipose tissue
• explain useful concepts in counseling patients about
behavioral changes to fight diseases
• discuss how adiposity and adipokines affect inflammation and
articular damage in rheumatoid arthritis
A404
Polymyalgia Rheumatica
Moderators: Bhaskar Dasgupta, MD; Southend University
Hospital; Essex, United Kingdom
Eric L. Matteson, MD; Mayo Clinic; Rochester, MN
tuesday
2010 Program Book 91