B O O K - American College of Rheumatology

tuesday
78
• advise patients about the safety issues related to treatments
for rheumatic diseases
• describe the evolutions at the Food and Drug Administration
that will affect drug safety monitoring and reporting
ACR Concurrent Abstract Sessions
4:30 - 6:00 PM
A402
B-Cell Biology and Targets in Autoimmune Disease
Moderators: Chaim Putterman, MD; Albert Einstein College of
Medicine; Bronx, NY
Yehuda Shoenfeld, MD; Sheba Medical Center; Ramat Gan, Israel
4:30 PM
1410. TLR7 and IFNα Influence B Cell Selection in the Germinal
Center.
Ioana Moisini 1 , Weiqing Huang 1 , Tony Marion 3 and Anne
Davidson 2 , 1 Feinstein Institute, 2 Feinstein Institute for Medical
Research, Manhasset, NY, 3 University of Tennessee
4:45 PM
1411. Impaired Somatic Hypermutation in Pre-Switch Memory
B Cells and Modulation of Mutational Targeting in Memory B
Cells during Tocilizumab Treatment in RA Patients.
Khalid Muhammad 1 , Petra Roll 1 , Stefan Kleinert 2 , Thomas
Seibold 2 , Martin Feuchtenberger 2 , Thomas Dörner 3 and Hans-
Peter Tony 2 , 1 Department of Medicine II, Rheumatology/Clinical
Immunology, University of Würzburg, Würzburg, Bayern,
Germany, 2 Department of Medicine II, Rheumatology/Clinical
Immunology, University of Würzburg, Würzburg, Germany,
3
Dept. of Medicine/Rheumatology and Clinical Immunology
Charite Universitätsmedizin Berlin and DRFZ Berlin, Berlin,
Germany
5:00 PM
1412. IL-17 Downregulates NF-КкB1/p50 and Upregulates
BCL6 To Promote Germinal Center B Cell Differentiation in
Autoimmune BXD2 Mice.
Shutao Xie 2 , Hui-Chen Hsu 2 , Jun Li 2 , Qi Wu 2 , PingAr Yang 2 and
John D. Mountz 1 , 1 Univ Alabama at Birmingham, Birmingham,
AL, 2 Univ Alabama at Birmingham
5:15 PM
1413. Targeting the Splicing of mRNA in Autoimmune Diseases:
BAFF Inhibition in Sjögren’s Syndrome as a Proof of Concept.
Nienke Roescher 5 , Jelle L. Vosters 2 , Ghada Al Saleh 6 , Patrick
Dreyfus 7 , Sebastien Jacques 4 , Luis Garcia 7 , Gilles Chiocchia 4 ,
Antoine Francois 6 , Jean Sibilia 6 , Paul P. Tak 1 , Jay A. Chiorini 5 ,
Xavier Mariette 3 and Jacques-Eric Gottenberg 6 , 1 Academic
Med Ctr/Univ of Amsterdam, Amsterdam, The Netherlands,
2
Academic Medical Center/University of Amsterdam, 3 Bicetre
Hospital, 4 Cochin Hospital, 5 National Institutes of Health,
National Institute of Dental and Craniofacial Research,
6
Strasbourg Hospital, EA 4438, 7 UMR 7215 CNRS, Institut de
Myologie
5:30 PM
1414. Adoptive Transfer of Long-Lived Plasma Cells from
NZB/W Mice Causes Immune Complex Nephritis in Recipient
Rag1-/- Mice.
IImtiaz M. Mumtaz 1 , Bimba F. Hoyer 1 , Andreas Radbruch 4 and
Falk Hiepe 2 , 1 Charité - Universitätsmedizin, Berlin, Germany,
2010 Program Book
2
Charité - Universitätsmedizin, Berlin, Berlin, Germany,
3
Charité - Universitätsmedizin Berlin, Berlin, Germany, 4 German
Rheumatism Research Center, Berlin, Germany
5:45 PM
1415. B Cells Induced Proteinuria and Glomerulopathy in
Absence of Immune Complexes Similar to Minimal Change
Disease.
Alfred H. Kim 1 and Andrey S. Shaw 2 , 1 Washington Univ School of
Med, St. Louis, MO, 2 Washington Univ School of Med
A411
Cell-Cell Adhesion, Cell Trafficking and Angiogenesis
Moderators: Bruce N. Cronstein, MD; New York University
Medical Center; New York, NY
Zoltan Szekanecz, MD, PhD, DSC; University of Debrecen Medical
Center; Debrecen, Hungary
4:30 PM
1416. Nuclear Factor-кB Inducing Kinase Is Preferentially
Expressed in Rheumatoid Arthritis Synovial Tissue Containing
Ectopic Lymphoid Neogenesis.
Ae-Ri Noort 2 , Katinka P. M. van Zoest 3 , Mariagrazia Modesti 4 ,
Sander W. Tas 2 and Paul P. Tak 1 , 1 Academic Med Ctr/Univ of
Amsterdam, Amsterdam, The Netherlands, 2 Academic Medical
Center/University of Amsterdam, The Netherlands, 3 Academic
Medical Center/University of Amsterdam, 4 University of Rome
4:45 PM
1417. CXCL16 as an Early Response Chemokine in Rat Adjuvant
and K/BxN Serum Induced Arthritis Models.
Jeffrey H. Ruth 2 , Chrisitian S. Haas 1 , M. Asif Amin 2 , G.
Kenneth Haines III 4 and Alisa E. Koch 3 , 1 University of Luebeck
- Department of Medicine I, Luebeck, Germany, 2 University of
Michigan Medical School, Ann Arbor, MI, 3 Unversity of Michigan,
Ann Arbor, MI, 4 Yale University Medical School
5:00 PM
1418. Angiogenic Potential of HMECs Is Driven by HIF-2α
Overcoming the Effects of HIF-1α.
Martin Hahne 2 , Steffi Luetkecosmann 1 , Cam Loan Tran 1 , Ferenz
Lohanatha 1 , Manuela Jakstadt 6 , Grit Kasper 4 , Georg Duda 4 , Paula
Kolar 4 , Timo Gaber 1 , Gerd R. Burmester 3 and Frank Buttgereit 5 ,
1
Berlin-Brandenburg Center for Regenerative Medicine, 2 Berlin-
Brandenburg School for Regenerative Medicine, Germany,
3
Charite - University Medicine, Berlin, Germany, 4 Charite -
University Medicine, 5 Charite University Med-Berlin, Berlin,
Germany, 6 German Rheumatism Research Center
5:15 PM
1419. Soluble Junctional Adhesion Molecule-A Promotes
Angiogenesis in Rheumatoid Arthritis.
Bradley J. Rabquer 1 , George Boychev 2 , Jeffrey H. Ruth 2 , Thilo
Stehle 3 and Alisa E. Koch 4 , 1University of Michigan, Ann Arbor,
MI, 2 University of Michigan, 3 University of Tubingen, 4 Unversity
of Michigan, Ann Arbor, MI.
5:30 PM
1420. Invasiveness of Rheumatoid Arthritis Synovial Fibroblasts
Is Affected by Extracellular RNA and DNA.
Birgit Zimmermann 3 , Silvia Fischer 1 , Stephanie Lefèvre 4 , Angela
Lehr 6 , Jürgen Steinmeyer 5 , Henning Stürz 2 , Thomas Umscheid 7 ,
Ulf Müller-Ladner 3 , Klaus T. Preissner 1 and Elena Neumann 3 ,
1
Dept of Biochemistry, Justus-Liebig-University Giessen, 2 Dept