B O O K - American College of Rheumatology

monday
2:45 pm
630. Adipogenic and Osteogenic Switch in Differentiation
of Human Mesenchymal Stem Cells (hMSCs) Is Triggered by
Hypoxia in a HIF-1 Dependent Manner.
Markus Wagegg 3 , Timo Gaber 1 , Ferenz Lohanatha 1 , Manuela
Jakstadt 1 , Grit Kasper 2 , Georg Duda 2 , Paula Kolar 3 , Gerd R.
Burmester 4 and Frank Buttgereit 5 , 1Berlin-Brandenburg Center
for Regenerative Therapies (BCRT), 2 Charité University Hospital,
Center for Musculoskeletal Surgery, Berlin, Germany, 3 Charité
University Hospital, Department of Rheumatology and Clinical
Immunology, Berlin, Germany, 4 Charité University Hospital,
Department of Rheumatology and Clinical Immunology, Berlin,
Germany, 5 Charite University Med-Berlin, Berlin, Germany
3:00 pm
631. Mitochondrial 8-Oxoguanine DNA Glycosylase (Ogg1)
Regulates the Cellular Function and Survival of Osteoarthritic
Chondrocytes in Response to Catabolic Stresses in
Osteoarthritis.
Kazuo Yudoh 2 and Rie Karasawa 1 , 1 Kawasaki, Japan, 2 St.
Marianna University School Medicine, Kawasaki City, Japan
3:15 pm
632. Advanced Glycation End Products (AGEs)-Induced
Expression of IL-6 and IL-8 in Human Osteoarthritis
Chondrocytes Correlates with the Induction of Endoplasmic
Reticulum Stress.
Zafar Rasheed, Nahid Akhtar and Tariq M. Haqqi, Department of
Medicine, Metrohealth/CWRU, Cleveland, OH
3:30 pm
633. MicroRNA-199a-*Mediated Regulation of
Cyclooxygenase-2 Expression in Human OA Chondrocytes.
Nahid Akhtar 1 , Zafar Rasheed 2 and Tariq M. Haqqi 1 , 1 Metrohealth
Medical Center/CWRU, Cleveland, OH, 2 Metrohealth Medical
Center/CWRU
3:45 pm
634. The Unfolded Protein Response (UPR) Is Impaired in Aging
and Osteoarthritic Cartilage Chondrocytes.
Matthew Husa 1 , Ru Liu-Bryan 2 , Shawn Grogan 3 , Haitao Yang 2 ,
Bing Yang 2 , Martin Lotz 3 and Robert Terkeltaub 2 , 1 San Diego
VA/UCSD, La Jolla, CA, 2 San Diego VA/UCSD, 3 Scripps Research
Institute
A315
Cytokines, Mediators, Gene Regulation I
Moderators: Alison Finnegan, PhD; Rush University Medical
Center; Chicago, IL
Oliver Distler, MD; University Hospital Zurich; Zurich, Switzerland
2:30 pm
Introductory Talk
John J. O’Shea, MD; NIAMS/NIH; Bethesda, MD
2:45 pm
635. Decreased Collagen Induced Arthritis (CIA) Severity in
MAPK Kinase 6 Deficient Mice: Pivotal Role of Th1 and Th17
Cytokines.
Deepa Hammaker 1 , Katharyn Topolewski 2 , Meghan Edgar 2 , David
L. Boyle 1 and Gary S. Firestein 1 , 1UCSD School of Medicine, La
Jolla, CA, 2 UCSD School of Medicine
3:00 pm
636. IL-7-Related TSLP: A Novel Potent Proinflammatory
Mediator in Rheumatoid Arthritis That Activates Myeloid
Dendritic Cells To Stimulate Th1 and Th17 Activity.
F. M. Moret, C. E. Hack, K. M. G. van der Wurff-Jacobs,
F. P. J. G. Lafeber and J. A. G. van Roon, Rheumatology &
Clinical Immunology, University Medical Center Utrecht, The
Netherlands
3:15 pm
637. Interleukin-12, Not the ITGAM Polymorphism (rs1143679),
Correlates with Atherosclerosis Independent of Disease Activity
in SLE.
Manish Jain, Erin McDonnell, Jill P. Buyon and Robert M. Clancy,
Department of Rheumatology, New York University School of
Medicine
3:30 pm
638. Pro-Inflammatory Properties of IL-35 and Its Association
with Disease Activity in Patients with Rheumatoid Arthritis.
Maria Filkova 2 , Hana Hulejova 3 , Marketa Polanska 3 , Lucie Andres
Cerezo 3 , Jiri Vencovsky 2 , Karel Pavelka 4 , Steffen Gay 1 and Ladislav
Senolt 3 , 1 Center of Experimental Rheumatology, University
Hospital and Zurich Center of Integrative Human Physiology
(ZIHP), Zurich, Switzerland, 2 Institute of Rheumatology and
Connective Tissue Research Laboratory, Department of
Rheumatology of the 1st Faculty of Medicine, Charles University
in Prague, Prague, Czech Republic, 3 Institute of Rheumatology
and Connective Tissue Research Laboratory, Department of
Rheumatology of the 1st Faculty of Medicine, Charles University
in Prague, Czech Republic, Czech Republic, 4 Institute of
Rheumatology, Department of Rheumatology of the 1st Faculty
of Medicine, Charles University in Prague, Czech Republic, Czech
Republic
3:45 pm
639. MAPK Kinase 3 (MKK3) Regulates Osteoclast
Differentiation and Activation.
David L. Boyle 3 , Meghan Edgar 4 , Mario M. Zaiss 1 , Georg Schett 2
and Gary S. Firestein 3 , 1 Department of Internal Medicine 3 ,
University of Erlangen-Nuremberg, 2 Friedrich Alexander Univ,
Erlangen, Germany, 3 UCSD School of Medicine, La Jolla, CA,
4
UCSD School of Medicine
A411
Epidemiology and Health Services Research:
Rheumatoid Arthritis
Moderators: Kaleb D. Michaud, PhD; University of Nebraska
Medical Center; Omaha, NE
Ted R. Mikuls, MD; University of Nebraska Medical Center;
Omaha, NE
2:30 pm
640. Tumor Necrosis Factor Inhibition Reduces the Incidence of
Alzheimer’s Disease in Rheumatoid Arthritis Patients.
Richard C. Chou 2 , Michael A. Kane 3 , Shiva Gautam 1 and Sanjay
Ghirmire 4 , 1Beth Israel Deaconess Medical Center, 2 Dartmouth-
Hitchcock Medical Center, Milton, MA, 3 Massachusetts
General Hospital and Massachusetts Institute of Technology,
Georgetown, MA, 4 Verisk Health
40
2010 Program Book