B O O K - American College of Rheumatology

A411
Rheumatoid Arthritis - Human Etiology and
Pathogenesis: RA Human Etiology and Pathogenesis I
Moderators: Gary S. Firestein, MD; University of California – San
Diego School of Medicine; La Jolla, CA
Ellen M. Gravallese, MD; University of Massachusetts Medical
School, Worchester, MA
2:30 PM
1386. Thrombin-Activatable Carboxypeptidase B (CPB) Plays a
Central Role in Down-Regulating Inflammatory Responses in
Rheumatoid Arthritis by Cleaving C5a.
Jason J. Song 3 , Inyong Hwang 3 , Tiffany Wang 4 , Annette T.
Lee 1 , S. Louis Bridges 5 , Peter K. Gregersen 1 , Lawrence Leung 4
and William Robinson 2 , 1North Shore-LIJ Research Institute,
Manhasset, NY, 2 Stanford Univ School of Med, Stanford, CA,
3
Stanford University, Palo Alto, CA, 4 Stanford University, 5 Univ of
Alabama-Birmingham, Birmingham, AL
2:45 PM
1387. The Liver X Receptor (LXR) Regulates Arthritis Fibroblast-
Like Synoviocyte NFB Activity, IL-6 Production and Cell Invasion.
Carl Petrus Linge 2 , Teresina Laragione 3 and Percio S. Gulko 1 ,
1
Feinstein Institutue Med Rsch, Manhasset, NY, 2 The Feinstein
Institute for Medical Research, Manhasset, NY, 3 The Feinstein
Institute for Medical Research
3:00 PM
1388. Cadherin-11 Engagement Increases Matrix
Metalloproteinase Production by Rheumatoid Arthritis
Fibroblast-Like Synoviocytes.
Erika H. Noss, Sook-Kyung Chang and Michael B. Brenner,
Brigham and Women’s Hospital, Boston, MA
3:15 PM
1389. Rheumatoid Synovial Fibroblasts Support Aid Expression
and IG Class-Switching in B Cells Via a BAFF-Dependent TLR3-
Stimulated Pathway.
Michele Bombardieri 1 , Yvone N. W. Kam 1 , Fabia Brentano 1 ,
Ken Choi 1 , Diego Kyburz 3 , Steffen Gay 3 , Iain B. McInnes 2 and
Costantino Pitzalis 1 , 1 Queen Mary University London, London,
United Kingdom, 2 University of Glasgow, Glasgow, United
Kingdom, 3 University of Zurich, Zurich, Switzerland
3:30 PM
1390. Characteristic Oral and Intestinal Microbiota in
Rheumatoid Arthritis (RA): A Trigger for Autoimmunity?
Jose U. Scher 7 , Carles Ubeda 3 , Michael H. Pillinger 2 , Walter
Bretz 6 , Yvonne Buischi 6 , Pamela B. Rosenthal 7 , Soumya M.
Reddy 7 , Jonathan Samuels 4 , Peter M. Izmirly 7 , Rennie N. G.
Howard 7 , Gary Solomon 8 , Yusuf Yazici 8 , Mukundan Attur 8 ,
Michele Equinda 3 , Nicholas Socci 3 , Agnes Viale 3 , Eric Pamer 1 ,
Dan R. Littman 9 , Gerald Weissmann 5 and Steven B. Abramson 10 ,
1
Lucille Castori Center for Microbes, Inflammation, and Cancer/
MSKCC, 2 Manhattan VA Med Hospital, New York, NY, 3 Memorial
Sloan-Kettering Cancer Center (MSKCC), 4 New York University
Hospital for Joint Disease, New York, NY, 5 New York University
Medical Center, New York, NY, 6 NYU College of Dentistry, 7 NYU
Hospital for Joint Diseases, New York, NY, 8 NYU Hospital for Joint
Diseases, 9 NYU School of Medicine, 10 NYU School of Medicine,
NYU Hospital for Joint Diseases, New York, NY
3:45 PM
1391. Toll-Like Receptor 2 Activation Induces Angiogenesis,
ICAM-1 Expression and EC Invasion in Rheumatoid Arthritis.
Tajvur P. Saber 2 , Sinead NicUltaigh 3 , Jennifer McCormick 2 ,
Douglas J. Veale 4 , Mary Connolly 2 and Ursula Fearon 1 , 1 Dublin,
Ireland, 2 Dublin Academic Medical Centre, Dublin, Ireland,
3
Dublin Academic Medical Centre, Dublin, Ireland, 4 St Vincents
Univ Hospital, Dublin, Ireland
Sidney J. Marcus Auditorium
Rheumatoid Arthritis Treatment - Small Molecules,
Biologics and Gene Therapy: Existing Non-Biologic
DMARDs II
Moderators: Eric M. Ruderman, MD; North Western University
of School of Medicine; Chicago, IL
Alvin F. Wells, MD, PhD; Rheumatology and Immunotherapy
Center; Oak Creek, WI
2:30 PM
1392. Radiological Progression in Patients with Early RA and a
Good Clinical Response to MTX Monotherapy: Predictors and
Clinical Implications.
Hamed Rezaei 3 , Ronald Van Vollenhoven 2 , Kristina Forslind 1 ,
Kristina Albertsson 3 , Helena Wallin 3 , Pierre Geborek 4 , Sofia
Ernestam 3 , Ingemar Petersson 5 and Johan Bratt 3 , 1 Helsingborgs
Hospital, 2 Karolinska University Hospital, Stockholm, Sweden,
3
Karolinska University Hospital, 4 Lund University Hospital,
5
Spenshult Hospital
2:45 PM
1393. In Early RA, Patients with a Good Initial Response to MTX
Monotherapy Have Excellent Clinical Outcomes over Two Years
of Therapy, but Radiological Progression Is Not Completely
Prevented.
Helena Wallin 4 , Ronald Van Vollenhoven 2 , Kristina Albertsson,
Kristina Forslind, Sofia Ernestam, Ingemar F. Petersson 3 , Pierre
Geborek, Hamed Rezaei, Johan Bratt 1 and The SWEFOT Study
Group, 1 Karolinska Univ Hosp Huddinge, Stockholm, Sweden,
2
Karolinska University Hospital, Stockholm, Sweden, 3 Lund
University Hosp, Lund, Sweden, 4 The Karolinska Institute,
Stockholm, Sweden
3:00 PM
1394. Genetic Polymorphisms in Key Methotrexate (MTX)
Pathway Genes Associated with Response to MTX Treatment in
Rheumatoid Arthritis.
Sally-Anne Owen 2 , Stephen Eyre 2 , Paul Martin 2 , Samantha
Hider 1 , Ian N. Bruce 2 , Anne Barton 2 and Wendy Thomson 2 , 1 ARC
National Primary Care Centre, Keele University, Staffordshire,
United Kingdom, 2 Arthritis Research UK Epidemiology Unit, The
University of Manchester, Manchester, United Kingdom
3:15 PM
1395. Observational Study To Evaluate the Relationship of
Methotrexate to Interstitial Lung Disease in Rheumatoid
Arthritis.
Liron Caplan 7 , Anne E. Hines 15 , Jay R. McDonald 10 , Angelique L.
Zeringue 10 , Alyse Mann 6 , Paul H. Sufka 13 , Kevin G. Osgood 2 , Ted
R. Mikuls 14 , Jasvinder Singh 3 , Itziar Quinzanos 5 , Lela Mansoori 11 ,
Chrysoula Pappa 12 , Leah M. Haverhals 6 , Andre Barkhuizen 8 ,
Douglas Phelps 1 , Roderick S. Hooker 4 , Hong Xian 10 , Prabha
Ranganathan 9 , Fran Cunningham 17 and Seth Eisen 16 , 1 Albancy
tuesday
2010 Program Book 73