B O O K - American College of Rheumatology

ACR Poster Session A
496. IRF8 Allele Associated with Susceptibility to Multiple
Sclerosis Is Associated with Serum Interferon Alpha and
Serologic Profile in Systemic Lupus Erythematosus. Beverly
S. Franek 2 , Silvia N. Kariuki 2 , Jasmine Arrington 2 , Rachel A.
Mikolaitis 3 , Meenakshi Jolly 3 , Tammy O. Utset 2 , Dimitrios T.
Boumpas 1 , George Goulielmos 1 and Timothy B. Niewold 2 ,
1
Internal Medicine and Rheumatology, Clinical Immunology and
Allergy, University of Crete Medical School, Heraklion, Greece,
2
Section of Rheumatology and Gwen Knapp Center for Lupus
and Immunology Research, University of Chicago, 3 Section of
Rheumatology, Rush University Medical Center.
497. Leptin Promotes T Cell Autoimmunity through Modulation of
the PKB/Akt/mTOR Pathway in Systemic Lupus Erythematosus
(SLE) Patients. Elaine V. Lourenco, Bevra H. Hahn, Noriko Iikuni,
Sarah J. Kim, Maida Wong, Ram P. Singh, Jennifer Grossman and
Antonio La Cava, UCLA.
498. Low C4A Gene Copy Number in Systemic Lupus
Erythematosus. Kaline M. C. Pereira 4 , Atila G. A. Faria 4 , Eloisa
S. Moreira 1 , Viviane C. Santos 3 , Marcelle Grecco 3 , Neusa P.
Silva 3 and Luis Eduardo C. Andrade 2 , 1 Hospital Sirio Libanes,
Brazil, 2 Universidade Federal de São Paulo, Sao Paulo,
Brazil, 3 Universidade Federal de Sao Paulo - UNIFESP, Brazil,
4
Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, SP,
Brazil.
499. Lupus Immune Complex Gene Expression Arrays Reveal
Divergent Pro- and Anti-Inflammatory Pathways Induced
Depending on the Presence of Plasmacytoid Dendritic Cells
and C1q. Deanna M. Santer and Keith B. Elkon, University of
Washington, Seattle, WA.
500. Meta-Analysis of Autoimmune Variants Shared between
Systemic Lupus Erythematosus (SLE) and 16 Other Diseases
Identifies Novel SLE Loci. Paula S. Ramos 3 , Patrick M. Gaffney 1 ,
Lindsey A. Criswell 12 , Mary E. Comeau 3 , Adrienne H. Williams 3 ,
Robert R. Graham 8 , Sharon A. Chung 10 , Raphael Zidovetzki 5 ,
Jennifer A. Kelly 2 , Kenneth M. Kaufman 2 , Chaim O. Jacob 9 ,
Robert P. Kimberly 4 , Betty P. Tsao 11 , Marta E. Alarcon-Riquelme 6 ,
Timothy J. Vyse 7 , John B. Harley 13 , Kathy L. Moser 1 , Carl D.
Langefeld 3 and SLEGEN Consortium, 1 Arthritis and Immunology
Program, Oklahoma Medical Research Foundation, Oklahoma
City, OK, 2 Arthritis and Immunology Program, Oklahoma Medical
Research Foundation, 3 Dept Biostatistical Sciences, Wake
Forest University Health Sciences, 4 Dept Medicine, University
of Alabama at Birmingham, Birmingham, AL, 5 Dept of Cell
Biology and Neuroscience, University of California, Riverside,
6
Dept of Genetics and Pathology, Uppsala University, Uppsala,
Sweden, 7 Faculty of Medicine, Imperial College, London, UK,
8
Immunology Biomarkers Group, Genentech, 9 Keck School of
Medicine, University of Southern California, Los Angeles, Los
Angeles, CA, 10 Rosalind Russell Medical Research Center for
Arthritis, University of California, San Francisco, San Francisco,
CA, 11 UCLA School of Medicine, Los Angeles, CA, 12 UCSF-Box
0500, San Francisco, CA, 13 Univ of OK Hlth Sci Ctr, Oklahoma
City, OK.
501. MicroRNA miR-146a, Type I Interferon, and Race in Systemic
Lupus Erythematosus. Paul R. Dominguez 1 , Minoru Satoh 2 ,
Angela R. Ceribelli 1 , Eric S. Sobel 2 , Yi Li 2 , Westley H. Reeves 2 and
Edward K. .L Chan 2 , 1 Department of Oral Biology, University of
Florida, Gainesville, FL, 2 University of Florida, Gainesville, FL.
502. Multiple Independent Major Histocompatibility Complex
Associations with Nephritis and Autoantibody Production in
Systemic Lupus Erythematosus. Sharon A. Chung 7 , Kimberly
E. Taylor 7 , Suzanne L. May 10 , Patricia P. Ramsay 9 , Hong L.
Quach 9 , Julie A. Lane 2 , Joanne Nititham 8 , Janelle A. Noble 2 ,
Diana L. Quach 9 , Jennifer A. Kelly 5 , Kathy L. Moser 4 , Timothy
W. Behrens 3 , Michael F. Seldin 11 , John B. Harley 1 , Patrick M.
Gaffney 4 , Lisa F. Barcellos 9 and Lindsey A. Criswell 6 , 1 Children’s
Hospital Cincinnati Medical Center, Cincinnati, OH, 2 Children’s
Hospital Oakland Research Institute, Oakland, CA, 3 Genentech,
Inc., South San Francisco, CA, 4 Oklahoma Medical Research
Foundation, Oklahoma City, OK, 5 Oklahoma Medical Research
Foundation, Oklahoma City, OK, 6 Rosalind Russell Medical
Research Center for Arthritis, University of California, San
Francisco, San Francisco, CA, 7 Rosalind Russell Medical Research
Center for Arthritis, University of California, San Francisco,
8
Rosalind Russell Medical Research Center for Arthritis,
University of California, San Francisco, CA, 9 University of
California, Berkeley, CA, 10 University of California, Berkely, CA,
11
University of California, Davis, CA.
503. NK Cells Regulate the IFN-α Production by Plasmacytoid
Dendritic Cells Via Soluble Factors and Cell-Cell Contact. Niklas
Hagberg 2 , Olof Berggren 2 , Gunnar V. Alm 1 , Maija-Leena Eloranta 2
and Lars Rönnblom 2 , 1 Department of Biomedical Sciences and
Veterinary Public Health, Swedish University of Agricultural
Sciences, Uppsala, Sweden, 2 Department of Medical Sciences,
Uppsala University, Uppsala, Sweden.
504. Novel Fc gamma Receptor 3B Gene (FCGR3B) Allele Variants
and Polymorphism Distribution in Brazilian Systemic Lupus
Erythematosus Patients and Blood Bank Donors. Viviane
C. Santos 2 , Marcelle Grecco 2 , Kaline M. C. Pereira 2 , Luis E. C.
Andrade 2 and Neusa P. Silva 1 , 1 Universidade Federal de São
Paulo, São Paulo, Brazil, 2 Universidade Federal de São Paulo,
Brazil.
505. Numerical and Functional Deficiencies of Natural Killer T Cells
in Systemic Lupus Erythematosus: Their Dysfunction Related
to Up-Regulation of Cbl-b. Young-Nan Cho 2 , Sung-Ji Lee 3 ,
Seong-Rye Seo 3 , Seung-Jung Kee 1 , Tae-Jong Kim 3 , Shin-Seok Lee 3
and Yong-Wook Park 2 , 1 Department of Laboratory Medicine,
Chonnam National University Medical School and Hospita,
2
Department of Rheumatology, Chonnam National University
Medical School and Hospital, Gwangju, Republic of Korea,
3
Department of Rheumatology, Chonnam National University
Medical School and Hospital.
506. Paucity of PD-L1 Expression on Monocytes during Active
Systemic Lupus Erythematosus Is Regulated by IL-10, TNF-α
and TGF-β. Anne M. Stevens 3 , Jing-Ni Ou 1 and Alice Wiedeman 2 ,
1
Center for Immunity and Immunotherapies, Seattle Children’s
Research Institute, Seattle, WA, 2 Department of Immunology,
University of Washington, Seattle, WA, 3 Pediatrics, U. of
Washington, Seattle, WA.
507. RFX1 Regulates CD70 and CD11a Expression by Recruiting
the Histone Methyltransferase SUV39H1 in Lupus T Cells.
Ming Zhao, Xiaoyan Wu, Fei Gao, Qing Zhang, Heng Yin and
Qianjin Lu, Second Xiangya Hospital, Central South University,
Changsha, China.
2010 Program Book 181