B O O K - American College of Rheumatology
B O O K - American College of Rheumatology
B O O K - American College of Rheumatology
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ACR/ARHP Poster Session B<br />
1111. Increasing Chance <strong>of</strong> Remission in Patients with Rheumatiod<br />
Arthritis. Anja Strangfeld 1 , Maria Eveslage 3 , Martin Aringer 4 ,<br />
Rainer Dockhorn 5 , Matthias Schneider 6 , Joachim Listing 3<br />
and Angela Zink 2 , 1 German Rheumatism Research Center,<br />
Berlin, Germany, 2 German Rheumatism Research Center and<br />
Charité University Medicine Berlin, 3 German Rheumatism<br />
Research Center, Berlin, 4 Rheumatologist, Dresden, Germany,<br />
5<br />
Rheumatologist, Weener, Weener, Germany, 6 Scientific<br />
Advisory Board, Düsseldorf.<br />
1112. Influence <strong>of</strong> ESR on EULAR Response Rates in Patients Treated<br />
with Tocilizumab. Results from the German Biologics Register<br />
RABBIT. Anja Strangfeld 1 , Maria Eveslage 1 , Joachim Listing 1 ,<br />
Peter Herzer 5 , Anke Liebhaber 4 , Brigitte Krummel-Lorenz 3<br />
and Angela Zink 2 , 1 German Rheumatism Research Center,<br />
Berlin, Germany, 2 German Rheumatism Research Center and<br />
Charité Berlin, Berlin, Germany, 3 Rheumatologist Frankfurt/M,<br />
Frankfurt, Germany, 4 Rheumatologist Halle/S, Halle/Saale,<br />
Germany, 5 Scientific Advisory Board, Munich, Munich, Germany.<br />
1113. Joint Space Narrowing Has a Stronger Impact on Physical<br />
Function Than Joint Erosion: Results from 8-Year Longitudinal<br />
Analyses. Desiree M. Van Der Heijde 2 , Robert Landewe 3 , Benoit<br />
Guerette 1 , Sanjoy Roy 1 , Kaushik Patra 1 and Ed C. Keystone 4 ,<br />
1<br />
Abbott Laboratories, 2 Leiden University Medical Center,<br />
Meerssen, The Netherlands, 3 Univ Hosp Maastricht, Maastricht,<br />
The Netherlands, 4 University <strong>of</strong> Toronto, Toronto, ON, Canada.<br />
1114. Magnetic Resonance Imaging Assessments <strong>of</strong> Patients with<br />
RA and Their Association with Clinical and Radiographic<br />
Outcomes. Paul Emery 3 , Desiree M. Van Der Heijde 6 , Mikkel<br />
Østergaard 5 , Philip G. Conaghan 4 , Mark C. Genovese 7 , Ed<br />
C. Keystone 9 , Roy M. Fleischmann 8 , Weichun Xu 1 , Stephen<br />
Xu 1 , Elizabeth C. Hsia 2 and Mahboob U. Rahman 2 , 1 Centocor<br />
Research and Development, Inc., 2 Centocor Research and<br />
Development, Inc./Univ. <strong>of</strong> Pennsylvania School <strong>of</strong> Medicine,<br />
Malvern, PA, 3 Chapel Allerton Hospital, Leeds, United Kingdom,<br />
4<br />
Chapel Allerton Hospital, Leeds, United Kingdom, 5 Copenhagen<br />
University Hospital at Glostrup and Hvidovre, 6 Leiden University<br />
Medical Center, Meerssen, The Netherlands, 7 Stanford<br />
University, Sunnyvale, CA, 8 University <strong>of</strong> Texas SW Medical<br />
Center, Dallas, TX, 9 University <strong>of</strong> Toronto, Toronto, ON, Canada.<br />
1115. Optimal Dose Prediction by Pharmacokinetic and Biomarker<br />
Response <strong>of</strong> Subcutaneous Tocilizumab Treatment – A<br />
Phase I/II Study Evaluating the Safety, Pharmacokinetics<br />
and Clinical Response in Patients with Rheumatoid Arthritis.<br />
Shuji Ohta 8 , Tomomi Tsuru 5 , Kimio Terao 2 , Seiji Mogi 7 , Midori<br />
Suzaki 4 , Hitoshi Nakashima 3 , Eisuke Shono 6 , Eriko Tarumi 1 and<br />
Masato Imai 6 , 1 Chugai Clinical Research Center Co., Ltd, 2 Chugai<br />
Pharmaceutical Co., Ltd., Tokyo, Japan, 3 Fukuoka University,<br />
4<br />
Med Co LTA PS Clinic, 5 Med Co LTA PS Clinic, Fukuoka, Japan,<br />
6<br />
Shono Rheumatism Clinic, 7 Taga General Hospital, Hitachi, Ltd,<br />
Japan 8 Taga General Hospital, Hitachi, Ltd, Japan.<br />
1116. Preclinical Development <strong>of</strong> Autologous, Autoantigen-Loaded<br />
Dendritic Cells Modified with Bay11-7082 for Tolerizing<br />
Immunotherapy in Anti-Citrullinated Peptide Antibody Positive<br />
Rheumatoid Arthritis Patients Bearing the HLA-DR Shared<br />
Epitope. Sakoontalla Ramnoruth 2 , Marion Brunck 2 , Claire Hyde 2 ,<br />
Shayna Street 2 , Ge<strong>of</strong>frey Strutton 1 , Christelle Capini 2 , Sebastien<br />
Bertin-Maghit 2 , Brendan O’Sullivan 2 and Ranjeny Thomas 2 ,<br />
1<br />
Queensland Health Pathology, 2 University <strong>of</strong> Queensland<br />
Diamantina Institute.<br />
1117. Prediction <strong>of</strong> One-Year Response to Etanercept and<br />
Methotrexate in Rheumatoid Arthritis Patients in TEMPO.<br />
Jeffrey R. Curtis 4 , Shuo Yang 7 , Lang Chen 6 , Grace S. Park 1 ,<br />
Bojena Bitman 2 , Brian C. Wang 3 , Iris Navarro-Millan 5 and<br />
Arthur Kavanaugh 8 , 1 Amgen Inc., Thousand Oaks, CA, 2 Amgen<br />
Inc., South San Francisco, CA, 3 KForce Clinical Research, South<br />
San Francisco, CA, 4 University <strong>of</strong> Alabama - Brimingham,<br />
Birmingham, AL, 5 University <strong>of</strong> Alabama at Birmingham,<br />
Vestavia, AL, 6 University <strong>of</strong> Alabama at Birmingham,<br />
Birmingham, AL, 7 University <strong>of</strong> Alabama at Birmingham,<br />
8<br />
University <strong>of</strong> California-San Diego, La Jolla, CA.<br />
1118. Predictors <strong>of</strong> Response to Rituximab in Patients with Active<br />
Rheumatoid Arthritis and Inadequate Response to Anti-TNF<br />
Agents or Traditional DMARD. Javier Narvaez 4 , Cesar Díaz<br />
Torné 2 , Jose Miguel Ruiz 3 , Maria Victoria Hernández 1 , Vicens<br />
Torrente 2 , Sergio Ros 3 , Cesar Díaz López 2 , Arturo Rodriguez<br />
de la Serna 2 , Raimon Sanmartí 1 and Joan Miquel Nolla 4 ,<br />
1<br />
Department <strong>of</strong> <strong>Rheumatology</strong>, Hospital Clinic, Barcelona, Spain,<br />
2<br />
Department <strong>of</strong> <strong>Rheumatology</strong>, Hospital de la Santa Creu i Sant<br />
Pau, Barcelona, Spain, 3 Department <strong>of</strong> <strong>Rheumatology</strong>, Hospital<br />
de Viladecans, Barcelona, Spain, 4 Department <strong>of</strong> <strong>Rheumatology</strong>,<br />
Hospital Universitario de Bellvitge, Barcelona, Spain.<br />
1119. Pro<strong>of</strong> <strong>of</strong> Concept Study for a Potent p38 MAPK Dual Action<br />
Inhibitor BMS-582949 in Subjects with RA Receiving<br />
Concomitant Methotrexate. Mark C. Genovese 6 , Ling Gao 3 , Jie<br />
Yin 3 , Stefani Smith 3 , Michael E. Weinblatt 1 , Josef S. Smolen 5 ,<br />
Xiaoning Wang 3 , Gary Schieven 3 , Juan A. Garcia-Meijide 4 , Robert<br />
Latek 3 , Richard Pasternak 3 , Sanjeev Kaul 3 , Amit Roy 3 , Ralph<br />
Raymond 3 , Ulrich Thienel 3 and Jingsong Wang 2 , 1 Brigham &<br />
Womens Hospital, Boston, MA, 2 Bristol-Myers Squibb, Wayne,<br />
PA, 3 Bristol-Myers Squibb, 4 Hospital Clínico Universitario de<br />
Santiago, Santiago de Compostela, Spain, 5 Krankenhaus Lainz,<br />
Vienna, Austria, 6 Stanford University, Sunnyvale, CA.<br />
1120. Radiographic Progression Correlates Well with Patient-<br />
Reported RAPID3 Disease Activity Levels in Methotrexate<br />
(MTX)-Naive Patients with Early Rheumatoid Arthritis (RA):<br />
Insights from the AGREE Study. Edward C. Keystone 3 , Rene<br />
Westhovens 4 , Diane Moniz Reed 1 , Allison Covucci 1 and Alvin<br />
F. Wells 2 , 1 Bristol-Myers Squibb, Princeton, NJ, 2 Rheum &<br />
Immunotherapy Center, Oak Creek, WI, 3 University <strong>of</strong> Toronto,<br />
Toronto, ON, Canada, 4 UZ Gasthuisburg, Leuven, Leuven,<br />
Belgium.<br />
1121. REGN88/SAR153191, a Fully-Human Interleukin-6 Receptor<br />
Monoclonal Antibody, Reduces Acute Phase Reactants in<br />
Patients with Rheumatoid Arthritis: Preliminary Observations<br />
from Phase 1 Studies. Allen R. Radin 1 , Scott J. Mellis 1 , Martine<br />
Jasson 3 , Douglas Nadler 2 , Pavel Belomestnov 2 , Richard Wu 2 ,<br />
Stephanie Biedermann 2 , Damir Skific 2 and Jennifer Hamilton 2 ,<br />
1<br />
Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 2 Regeneron<br />
Pharmaceuticals, Inc., 3 San<strong>of</strong>i-aventis, SA.<br />
1122. Results from a Phase I Study <strong>of</strong> MLTA3698A, a Novel Anti-<br />
Lymphotoxin-a Monoclonal Antibody: Safety, Tolerability and<br />
Biologic Activity in Patients with Active Rheumatoid Arthritis.<br />
Brinda Emu 2 , Diana Luca 3 , Carolyn Offutt 3 , Jane Grogan 3 , John<br />
Davis 3 , Bernadette Rojkovich 1 , Marna Williams 3 , Meina Tang 3<br />
and June Lee 3 , 1 Budai Irgalmasrendi, 2 Genentech, Inc., South San<br />
Francisco, CA, 3 Genentech, Inc..<br />
2010 Program Book 217