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B O O K - American College of Rheumatology

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ACR/ARHP Poster Session B<br />

1111. Increasing Chance <strong>of</strong> Remission in Patients with Rheumatiod<br />

Arthritis. Anja Strangfeld 1 , Maria Eveslage 3 , Martin Aringer 4 ,<br />

Rainer Dockhorn 5 , Matthias Schneider 6 , Joachim Listing 3<br />

and Angela Zink 2 , 1 German Rheumatism Research Center,<br />

Berlin, Germany, 2 German Rheumatism Research Center and<br />

Charité University Medicine Berlin, 3 German Rheumatism<br />

Research Center, Berlin, 4 Rheumatologist, Dresden, Germany,<br />

5<br />

Rheumatologist, Weener, Weener, Germany, 6 Scientific<br />

Advisory Board, Düsseldorf.<br />

1112. Influence <strong>of</strong> ESR on EULAR Response Rates in Patients Treated<br />

with Tocilizumab. Results from the German Biologics Register<br />

RABBIT. Anja Strangfeld 1 , Maria Eveslage 1 , Joachim Listing 1 ,<br />

Peter Herzer 5 , Anke Liebhaber 4 , Brigitte Krummel-Lorenz 3<br />

and Angela Zink 2 , 1 German Rheumatism Research Center,<br />

Berlin, Germany, 2 German Rheumatism Research Center and<br />

Charité Berlin, Berlin, Germany, 3 Rheumatologist Frankfurt/M,<br />

Frankfurt, Germany, 4 Rheumatologist Halle/S, Halle/Saale,<br />

Germany, 5 Scientific Advisory Board, Munich, Munich, Germany.<br />

1113. Joint Space Narrowing Has a Stronger Impact on Physical<br />

Function Than Joint Erosion: Results from 8-Year Longitudinal<br />

Analyses. Desiree M. Van Der Heijde 2 , Robert Landewe 3 , Benoit<br />

Guerette 1 , Sanjoy Roy 1 , Kaushik Patra 1 and Ed C. Keystone 4 ,<br />

1<br />

Abbott Laboratories, 2 Leiden University Medical Center,<br />

Meerssen, The Netherlands, 3 Univ Hosp Maastricht, Maastricht,<br />

The Netherlands, 4 University <strong>of</strong> Toronto, Toronto, ON, Canada.<br />

1114. Magnetic Resonance Imaging Assessments <strong>of</strong> Patients with<br />

RA and Their Association with Clinical and Radiographic<br />

Outcomes. Paul Emery 3 , Desiree M. Van Der Heijde 6 , Mikkel<br />

Østergaard 5 , Philip G. Conaghan 4 , Mark C. Genovese 7 , Ed<br />

C. Keystone 9 , Roy M. Fleischmann 8 , Weichun Xu 1 , Stephen<br />

Xu 1 , Elizabeth C. Hsia 2 and Mahboob U. Rahman 2 , 1 Centocor<br />

Research and Development, Inc., 2 Centocor Research and<br />

Development, Inc./Univ. <strong>of</strong> Pennsylvania School <strong>of</strong> Medicine,<br />

Malvern, PA, 3 Chapel Allerton Hospital, Leeds, United Kingdom,<br />

4<br />

Chapel Allerton Hospital, Leeds, United Kingdom, 5 Copenhagen<br />

University Hospital at Glostrup and Hvidovre, 6 Leiden University<br />

Medical Center, Meerssen, The Netherlands, 7 Stanford<br />

University, Sunnyvale, CA, 8 University <strong>of</strong> Texas SW Medical<br />

Center, Dallas, TX, 9 University <strong>of</strong> Toronto, Toronto, ON, Canada.<br />

1115. Optimal Dose Prediction by Pharmacokinetic and Biomarker<br />

Response <strong>of</strong> Subcutaneous Tocilizumab Treatment – A<br />

Phase I/II Study Evaluating the Safety, Pharmacokinetics<br />

and Clinical Response in Patients with Rheumatoid Arthritis.<br />

Shuji Ohta 8 , Tomomi Tsuru 5 , Kimio Terao 2 , Seiji Mogi 7 , Midori<br />

Suzaki 4 , Hitoshi Nakashima 3 , Eisuke Shono 6 , Eriko Tarumi 1 and<br />

Masato Imai 6 , 1 Chugai Clinical Research Center Co., Ltd, 2 Chugai<br />

Pharmaceutical Co., Ltd., Tokyo, Japan, 3 Fukuoka University,<br />

4<br />

Med Co LTA PS Clinic, 5 Med Co LTA PS Clinic, Fukuoka, Japan,<br />

6<br />

Shono Rheumatism Clinic, 7 Taga General Hospital, Hitachi, Ltd,<br />

Japan 8 Taga General Hospital, Hitachi, Ltd, Japan.<br />

1116. Preclinical Development <strong>of</strong> Autologous, Autoantigen-Loaded<br />

Dendritic Cells Modified with Bay11-7082 for Tolerizing<br />

Immunotherapy in Anti-Citrullinated Peptide Antibody Positive<br />

Rheumatoid Arthritis Patients Bearing the HLA-DR Shared<br />

Epitope. Sakoontalla Ramnoruth 2 , Marion Brunck 2 , Claire Hyde 2 ,<br />

Shayna Street 2 , Ge<strong>of</strong>frey Strutton 1 , Christelle Capini 2 , Sebastien<br />

Bertin-Maghit 2 , Brendan O’Sullivan 2 and Ranjeny Thomas 2 ,<br />

1<br />

Queensland Health Pathology, 2 University <strong>of</strong> Queensland<br />

Diamantina Institute.<br />

1117. Prediction <strong>of</strong> One-Year Response to Etanercept and<br />

Methotrexate in Rheumatoid Arthritis Patients in TEMPO.<br />

Jeffrey R. Curtis 4 , Shuo Yang 7 , Lang Chen 6 , Grace S. Park 1 ,<br />

Bojena Bitman 2 , Brian C. Wang 3 , Iris Navarro-Millan 5 and<br />

Arthur Kavanaugh 8 , 1 Amgen Inc., Thousand Oaks, CA, 2 Amgen<br />

Inc., South San Francisco, CA, 3 KForce Clinical Research, South<br />

San Francisco, CA, 4 University <strong>of</strong> Alabama - Brimingham,<br />

Birmingham, AL, 5 University <strong>of</strong> Alabama at Birmingham,<br />

Vestavia, AL, 6 University <strong>of</strong> Alabama at Birmingham,<br />

Birmingham, AL, 7 University <strong>of</strong> Alabama at Birmingham,<br />

8<br />

University <strong>of</strong> California-San Diego, La Jolla, CA.<br />

1118. Predictors <strong>of</strong> Response to Rituximab in Patients with Active<br />

Rheumatoid Arthritis and Inadequate Response to Anti-TNF<br />

Agents or Traditional DMARD. Javier Narvaez 4 , Cesar Díaz<br />

Torné 2 , Jose Miguel Ruiz 3 , Maria Victoria Hernández 1 , Vicens<br />

Torrente 2 , Sergio Ros 3 , Cesar Díaz López 2 , Arturo Rodriguez<br />

de la Serna 2 , Raimon Sanmartí 1 and Joan Miquel Nolla 4 ,<br />

1<br />

Department <strong>of</strong> <strong>Rheumatology</strong>, Hospital Clinic, Barcelona, Spain,<br />

2<br />

Department <strong>of</strong> <strong>Rheumatology</strong>, Hospital de la Santa Creu i Sant<br />

Pau, Barcelona, Spain, 3 Department <strong>of</strong> <strong>Rheumatology</strong>, Hospital<br />

de Viladecans, Barcelona, Spain, 4 Department <strong>of</strong> <strong>Rheumatology</strong>,<br />

Hospital Universitario de Bellvitge, Barcelona, Spain.<br />

1119. Pro<strong>of</strong> <strong>of</strong> Concept Study for a Potent p38 MAPK Dual Action<br />

Inhibitor BMS-582949 in Subjects with RA Receiving<br />

Concomitant Methotrexate. Mark C. Genovese 6 , Ling Gao 3 , Jie<br />

Yin 3 , Stefani Smith 3 , Michael E. Weinblatt 1 , Josef S. Smolen 5 ,<br />

Xiaoning Wang 3 , Gary Schieven 3 , Juan A. Garcia-Meijide 4 , Robert<br />

Latek 3 , Richard Pasternak 3 , Sanjeev Kaul 3 , Amit Roy 3 , Ralph<br />

Raymond 3 , Ulrich Thienel 3 and Jingsong Wang 2 , 1 Brigham &<br />

Womens Hospital, Boston, MA, 2 Bristol-Myers Squibb, Wayne,<br />

PA, 3 Bristol-Myers Squibb, 4 Hospital Clínico Universitario de<br />

Santiago, Santiago de Compostela, Spain, 5 Krankenhaus Lainz,<br />

Vienna, Austria, 6 Stanford University, Sunnyvale, CA.<br />

1120. Radiographic Progression Correlates Well with Patient-<br />

Reported RAPID3 Disease Activity Levels in Methotrexate<br />

(MTX)-Naive Patients with Early Rheumatoid Arthritis (RA):<br />

Insights from the AGREE Study. Edward C. Keystone 3 , Rene<br />

Westhovens 4 , Diane Moniz Reed 1 , Allison Covucci 1 and Alvin<br />

F. Wells 2 , 1 Bristol-Myers Squibb, Princeton, NJ, 2 Rheum &<br />

Immunotherapy Center, Oak Creek, WI, 3 University <strong>of</strong> Toronto,<br />

Toronto, ON, Canada, 4 UZ Gasthuisburg, Leuven, Leuven,<br />

Belgium.<br />

1121. REGN88/SAR153191, a Fully-Human Interleukin-6 Receptor<br />

Monoclonal Antibody, Reduces Acute Phase Reactants in<br />

Patients with Rheumatoid Arthritis: Preliminary Observations<br />

from Phase 1 Studies. Allen R. Radin 1 , Scott J. Mellis 1 , Martine<br />

Jasson 3 , Douglas Nadler 2 , Pavel Belomestnov 2 , Richard Wu 2 ,<br />

Stephanie Biedermann 2 , Damir Skific 2 and Jennifer Hamilton 2 ,<br />

1<br />

Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 2 Regeneron<br />

Pharmaceuticals, Inc., 3 San<strong>of</strong>i-aventis, SA.<br />

1122. Results from a Phase I Study <strong>of</strong> MLTA3698A, a Novel Anti-<br />

Lymphotoxin-a Monoclonal Antibody: Safety, Tolerability and<br />

Biologic Activity in Patients with Active Rheumatoid Arthritis.<br />

Brinda Emu 2 , Diana Luca 3 , Carolyn Offutt 3 , Jane Grogan 3 , John<br />

Davis 3 , Bernadette Rojkovich 1 , Marna Williams 3 , Meina Tang 3<br />

and June Lee 3 , 1 Budai Irgalmasrendi, 2 Genentech, Inc., South San<br />

Francisco, CA, 3 Genentech, Inc..<br />

2010 Program Book 217

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