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B O O K - American College of Rheumatology

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ACR/ARHP Poster Session C<br />

1988. Characterization <strong>of</strong> Single Histone Deacetylase Is<strong>of</strong>orms<br />

in Endothelial Cells Derived from Progenitors in Systemic<br />

Sclerosis. Hossein Hemmatazad 1 , Britta Maurer 1 , Beat A.<br />

Michel 1 , Renate E. Gay 1 , Gay Steffen 1 , Jèrome Avouac 2 , Oliver<br />

Distler 1 , Yannick Allanore 2 and Astrid Jüngel 1 , 1 Center <strong>of</strong><br />

Experimental <strong>Rheumatology</strong>, University Hospital and Zurich<br />

Center <strong>of</strong> Integrative Human Physiology (ZIHP), Zurich,<br />

Switzerland, 2 Department <strong>of</strong> <strong>Rheumatology</strong> A, Cochin Hospital,<br />

Universitè Paris Descartes, INSERM U781, Paris, France.<br />

1989. Circulating T Cell Polarization Is Associated with Respiratory<br />

Decline in Scleroderma Patients with Active Interstitial Lung<br />

Disease. Francesco Boin 1 , Fredrick Wigley 2 , Robert Wise 2 and<br />

Antony Rosen 2 , 1 Johns Hopkins University, Baltimore, MD,<br />

2<br />

Johns Hopkins University.<br />

1990. Does Treatment with Imatinib Modify Gene Expression in the<br />

Skin and Peripheral Blood Mononuclear Cells <strong>of</strong> Patient with<br />

Systemic Sclerosis? Jessica K. Gordon 1 , Robert Spiera 2 , Jamie<br />

N. Mersten 1 , Horatio F. Wildman 4 , Ziad Taimeh 3 , Neil Hackett 4 ,<br />

Sasa Vukelic 3 , Kyriakos A. Kirou 1 and Mary K. Crow 1 , 1 Hospital for<br />

Special Surgery, New York, NY, 2 Hospital for Special Surgery, New<br />

York, NY, 3 Hospital for Special Surgery, 4 Weill-Cornell Medical<br />

<strong>College</strong>.<br />

1991. Enhanced Expression <strong>of</strong> Ephrins and Thrombospondins in<br />

the Dermis <strong>of</strong> Patients with Early Diffuse Systemic Sclerosis:<br />

Potential Contribution to Perturbed Angiogenesis and Fibrosis.<br />

Jerome Avouac 6 , Maud Clemessy 2 , Jorg H. W. Distler 8 , Jean<br />

Marie Gasc 2 , Barbara Ruiz 1 , Marie Cecile Vacher-Lavenu 3 ,<br />

Julien Wipff 6 , Andre Kahan 4 , Catherine Boileau 7 , Pierre Corvol 2<br />

and Yannick Allanore 5 , 1 INSERM U781, Necker Hospital, Paris,<br />

France, 2 INSERM U833 and Collège de France, Paris, France,<br />

3<br />

Paris Descartes University, Pathophysiology Department,<br />

Cochin Hospital, Paris, France, 4 Paris Descartes University,<br />

<strong>Rheumatology</strong> A Department, Cochin Hospital, APHP,<br />

Paris, France, 5 Paris Descartes University, <strong>Rheumatology</strong> A<br />

Department, Cochin Hospital, APHP, Paris and INSERM U781,<br />

Necker Hospital, Paris, France, 6 Paris Descartes University,<br />

<strong>Rheumatology</strong> A Department, Cochin Hospital, APHP, Paris<br />

and INSERM U781, Necker Hospital, Paris, France, 7 U.V.S.Q<br />

University, Biochemistry, Hormonology and Molecular Genetics<br />

Department, Ambroise Paré Hospital, AP-HP, Boulogne, France,<br />

8<br />

University <strong>of</strong> Erlangen, Erlangen, Germany.<br />

1992. Enhanced IL-17A and IL-22 Production by Peripheral Blood<br />

Mononuclear Cells Distinguish Systemic Sclerosis from Healthy<br />

Individuals. Nicolò C. Brembilla 1 , Marie-Elise Truchetet 2 ,<br />

Elisa Montanari 1 , Yannick Allanore 3 and Carlo Chizzolini 1 ,<br />

1<br />

Immunology & Allergy, Geneva University Hospital, Geneva,<br />

Switzerland, 2 Immunology Allergy, Geneva University Hospital,<br />

Geneva, Switzerland, 3 <strong>Rheumatology</strong>, Cochin Hospital, Paris,<br />

Paris, France.<br />

1993. Gd Compounds Signaling through Toll-Like Receptors 4<br />

and 7 in Normal Human Macrophages: Establishment <strong>of</strong><br />

a Proinflammatory Phenotype and Implications for the<br />

Pathogenesis <strong>of</strong> Nephrogenic Systemic Fibrosis. Peter J.<br />

Wermuth 1 and Sergio A. Jimenez 2 , 1 Jefferson Institute <strong>of</strong><br />

Molecular Medicine and Division <strong>of</strong> Connective Tissue Diseases,<br />

Thomas Jefferson University, Philadelphia, PA, 2 Thomas<br />

Jefferson Univ, Philadelphia, PA.<br />

1994. Genome-Wide Association Study in Systemic Sclerosis. Yannick<br />

Allanore 5 , Mohammad Saad 2 , Philippe Dieudé 4 , Catherine<br />

Boileau 1 , Maria Martinez 3 and GENESYS Consortium, 1 Biochimie<br />

A. Paré Hospital, Université VSQ, Boulogne, France, 2 INSERM<br />

U563 Université Paul Sabatier, Toulouse, France, 3 NSERM U563<br />

Université Paul Sabatier, Toulouse, France, 4 Rhumatologie,<br />

Inserm u699, Bichat, Paris Diderot Universite, France,<br />

5<br />

Université Paris Descarte, Rhumatologie A, INSERM U781,<br />

Paris, Paris, France.<br />

1995. High Resolution Magnetic Resonance Imaging for the<br />

Assessment <strong>of</strong> Dermal Fibrosis in a Pre-Clinical Model <strong>of</strong><br />

Scleroderma. Helen Jones 1 , Emma Derrett-Smith 1 , Chris P.<br />

Denton 1 , David Abraham 1 , George Bou-Gharios 2 and Po-Wah<br />

So 3 , 1 Centre for <strong>Rheumatology</strong>, UCL Medical School, 2 Kennedy<br />

Institute <strong>of</strong> <strong>Rheumatology</strong>, Imperial <strong>College</strong> London, 3 Pre-clinical<br />

Imaging Unit, Institute <strong>of</strong> Psychiatry, King’s <strong>College</strong> London.<br />

1996. IL-6 Overexpression in Early dcSSc Associates with Poor Clinical<br />

Outcome and May Drive Fibrotic Response. Korsa Khan 1 ,<br />

Shiwen Xu 1 , Christopher P. Denton 2 and Voon Ong 1 , 1 Center for<br />

<strong>Rheumatology</strong> and Connective Tissue Diseases, UCL Medical<br />

School, Royal Free Hospital, London, United Kingdom, 2 Royal<br />

Free Hospital, London, United Kingdom.<br />

1997. Imatinib Mesylate and Rottlerin Abrogate Transforming<br />

Growth Factor-β Induction <strong>of</strong> Endothelial-to-Mesenchymal<br />

Transition in Primary Lung Endothelial Cells. Zhaodong Li and<br />

Sergio A. Jimenez, Jefferson Institute <strong>of</strong> Molecular Medicine,<br />

Thomas Jefferson Univ, Philadelphia, PA.<br />

1998. In Systemic Sclerosis, Cooperation between B-Cells and Skin<br />

Fibroblasts Promotes Fibrogenic Cytokines and Collagen<br />

Production. Antoine Francois 3 , Dominique Wachsmann 3 , Jean<br />

Sibilia 1 and Jacques E. Gottenberg 2 , 1 Strasbourg Hospitals,<br />

Illkirch Graffenstaden, France, 2 Strasbourg Hospitals, Strasbourg,<br />

France, 3 Universite de Strasbourg, Illkirch Graffenstaden, France.<br />

1999. Inhibition <strong>of</strong> Glycogen Synthase Kinase (GSK)-3β<br />

Downregulates Collagen I Gene Expression in Normal and<br />

Scleroderma Fibroblasts and Abrogates the Pr<strong>of</strong>ibrotic Effects<br />

<strong>of</strong> Transforming Growth Factor β (TGF-β). Jolanta Fertala and<br />

Sergio A. Jimenez, Jefferson Institute <strong>of</strong> Molecular Medicine,<br />

Thomas Jefferson University, Philadelphia, PA.<br />

2000. Insights into the Pathogenesis <strong>of</strong> Systemic Sclerosis<br />

Vasculopathy Based on Gene Expression Pr<strong>of</strong>ile <strong>of</strong> Endothelial<br />

Cells Issued from Progenitors. Jerome Avouac 5 , Nicolas<br />

Cagnard 1 , Jorg H. W. Distler 6 , Yoland Schoindre 2 , Barbara Ruiz 2 ,<br />

Catherine Boileau 2 , Gilles Chiocchia 3 and Yannick Allanore 4 ,<br />

1<br />

INSERM U567, Cochin Hospital, APHP, Paris, France, 2 INSERM<br />

U781, Necker Hospital, Paris, France, 3 NSERM U567, Cochin<br />

Hospital, APHP, Paris, France, 4 Paris Descartes University,<br />

<strong>Rheumatology</strong> A Department, Cochin Hospital, APHP, Paris and<br />

INSERM U781, Necker Hospital, Paris, France, 5 Paris Descartes<br />

University, <strong>Rheumatology</strong> ADdepartment, Cochin Hospital,<br />

APHP, Paris and INSERM U781, Necker Hospital, 6 University <strong>of</strong><br />

Erlangen, Erlangen, Germany.<br />

2001. PDGF Receptor as Therapeutic and Diagnostic Target in<br />

Systemic Sclerosis. Gianluca Moroncini 4 , Antonella Grieco 5 ,<br />

Chiara Paolini 5 , Giulia Nacci 3 , Massimiliano Cuccioloni 2 , Matteo<br />

Mozzicafreddo 2 , Cecilia Tonnini 5 , Katarzyna Pozniak 5 , Silvia<br />

Svegliati 5 , Mauro Angeletti 2 , Enrico Avvedimento 1 , Ada Funaro 3<br />

and Armando Gabrielli 5 , 1 Dipartimento di Biologia e Patologia<br />

Molecolare e Cellulare, Università Federico II, Napoli, Italy,<br />

2<br />

Dipartimento di Biologia Molecolare, Cellulare e Animale,<br />

Università di Camerino, Italy, 3 Dipartimento di Genetica, Biologia<br />

e Biochimica, Università di Torino, Italy, 4 Dipartimento di Scienze<br />

Mediche e Chirurgiche, Clinica Medica, Università Politecnica<br />

delle Marche, Ancona, Italy, 5 Dipartimento di Scienze Mediche e<br />

Chirurgiche, Clinica Medica, Università Politecnica delle Marche,<br />

Ancona, Italy.<br />

2002. Proteomic Analysis <strong>of</strong> Systemic Sclerosis Serum Identifies the<br />

Toll-Like Receptor Agonists S100A8/A9 as a Novel Possible<br />

Pathogenic Marker. Lenny van Bon 3 , Arnoud Lo<strong>of</strong> 3 , Helmut<br />

Wittkowski 1 , Waander van Heerde 3 , Madelon Vonk 3 , Johannes<br />

Roth 1 , Wim B. Van Den Berg 2 , Peter van Lent 3 and Timothy<br />

Radstake 3 , 1 Interdisciplinary Centre for Clinical Research<br />

University <strong>of</strong> Muenster, 2 Radboud Univ Nijmegen Med Cntr,<br />

Nijmegen, The Netherlands, 3 Radboud University Medical<br />

Centre Nijmegen, The Netherlands.<br />

2010 Program Book 273

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