B O O K - American College of Rheumatology

ACR Poster Session A
Cytokines, Mediators, Gene Regulation I
15. BAFF Expression Correlates with Idiopathic Inflammatory
Myopathy Disease Activity Measures, Interferon Signature
and Autoantibodies. Kelly T. McNallan 1 , Hatice Bilgic 3 , Cynthia
S. Crowson 2 , Steven R. Ytterberg 2 , Shreyasee Amin 2 , Peterson
J. Erik 3 , Emily C. Baechler 3 and Ann M. Reed 2 , 1 Mayo Clinic,
Rochester, MN, 2 Mayo Clinic, 3 University of Minnesota.
16. Blockade of TLR2 Prevents Spontaneous and Induced Cytokine
Release from Rheumatoid Arthritis Ex Vivo Synovial Explant
Cultures. Sinead Nic An Ultaigh 1 , Tajvur Saber 1 , Jerome
Dellacasagrande 2 , Brian Keogh 2 , William McCormack 2 , Mary
Reilly 2 , Luke O’ Neill 2 , Peter McGuirk 2 , Ursula Fearon 1 and
Douglas J. Veale 1 , 1 Dublin Academic Medical Centre, Dublin,
Ireland, 2 Opsona Therapeutics Ltd, Dublin, Ireland.
17. CCL15/Leukotactin-1: A Novel Mediator of Rheumatoid
Arthritis Fibroblast-Like Synoviocyte Migration Via CCR3 and
MAP Kinases. Eric K. Owens 1 , Karolina Klosowska 2 , Michael
V. Volin 2 , Brian Zanotti 2 and James M. Woods 2 , 1 Midwestern
University, Downers Grove, IL, 2 Midwestern University.
18. Chronic Exposure to IL-6 Amplifies Macrophage Response to
Toll-Like Receptor (TLR) Ligands. Raffaele Strippoli 1 , Francesco
Carvello 2 , Loredana De Pasquale 2 , Luisa Bracci-Laudiero 2 and
Fabrizio de Benedetti 2 , 1 IRCCS Ospedale Pediatrico Bambino
Gesu, Rome, Italy, 2 IRCCS Ospedale Pediatrico Bambino Gesu,
Rome, Italy.
19. CX3CR1 Deficient Mice Have Decreased Th17 and Antigen-
Specific Humoral Responses in the Collagen Induced Arthritis
(CIA) Model. Teresa K. Tarrant 2 , Peng Liu 3 , Rishi Rampersad 3 ,
Denise Esserman 3 , Lisa Rothlein, Marcus W. McGinnis 3 , David J.
Fitzhugh 3 , Dhavalkumar D. Patel 1 and Alan M. Fong 3 , 1 Novartis
Pharma AG, Basel, Switzerland, 2 UNC School of Medicine,
Chapel Hill, NC, 3 UNC School of Medicine.
20. Cytokine Expression in Synovial Tissue of Psoriatic Arthritis
and Its Relation to Lymphoid Neogenesis, Erosive Disease
and Disease Activity: A Longitudinal Study. Raquel Celis 1 ,
Julio Ramírez 1 , Raimon Sanmarti 1 , José L. Pablos 2 and Juan D.
Cañete 1 , 1 Servicio Reumatología, Hospital Clinic and IDIBAPS,
Barcelona, Spain, 2 Unidad de Investigación, Hospital 12 de
Octubre, Madrid, Spain.
21. DNA Hypomethylation Upregulates CXCL12 in Rheumatoid
Arthritis Synovial Fibroblasts. Emmanuel Karouzakis 1 , Yvonne
Rengel 1 , Astrid Jüngel 1 , Christoph Kolling 3 , Renate E. Gay 1 ,
Beat A. Michel 1 , Paul P. Tak 2 , Steffen Gay 1 , Michel Neidhart 1
and Caroline Ospelt 1 , 1 Center of Experimental Rheumatology
and Zurich Center of Integrative Human Physiology (ZIHP),
University Hospital Zurich, 2 Department of Clinical Immunology
and Rheumatology, University of Amsterdam, 3 Schulthess Clinic,
Zürich.
22. Downregulation of the Chemokine Receptor CX3CR1 in Active
RA Associated with a Pro-Osteoclastognic Phenotype. Grainne
Murphy 1 , John Ryan 1 , Harney Sinead 1 , Fergus Shanahan 1 ,
Michael Molloy 1 and Noel Caplice 2 , 1 Cork University Hospital,
Cork, Ireland, 2 University College Cork, Cork, Ireland.
23. Downstream Targets of IL-17 in Rheumatoid Arthritis. Sarah
R. Pickens 4 , Richard M. Pope 3 , Michael V. Volin 1 and Shiva
Shahrara 2 , 1 Midwestern University, 2Northwestern Univ
Feinberg, Chicago, IL, 3 Northwestern Univ Med School, Chicago,
IL, 4 Northwestern University.
24. Elevated BLyS Levels Are Associated with an Increase in
Autoantibody Specificites and ANA Titer in Systemic Lupus
Erythematosus. Lauren L. Ritterhouse 3 , Amanda R. Moyer 3 ,
Virginia C. Roberts 2 , Amy B. Dedeke 2 , Sherry R. Crowe 3 , Gillian
M. Air 4 , Linda F. Thompson 3 , Joel M. Guthridge 3 and Judith A.
James 1 , 1 Oklahoma Med Research Foundation, Oklahoma City,
OK, 2 Oklahoma Medical Research Foundation, Oklahoma City,
OK, 3 Oklahoma Medical Research Foundation, 4 University of
Oklahoma Health Sciences Center.
25. Elevated Levels of CXCL9 or CXCL10 in Sera of Patients with
Early RA Predict Greater Difficulty in Achieving Remission
during the First Year of Treatment. Gregory R. Emkey 5 ,
Klemen Strle 6 , Christopher R. Antolini 3 , Deborah S. Collier 5 ,
Margaret Seton 5 , Arezou Khosroshahi 5 , Mark Fisher 2 , Nancy D.
Kim 4 , John H. Stone 1 , Andrew D. Luster 4 and Allen C. Steere 5 ,
1
Massachusetts General Hospital, Sudbury, MA, 2 Massachusetts
General Hospital, Haddon Heights, NJ, 3 Massachusetts General
Hospital, Denver, CO, 4 Massachusetts General Hospital,
Charlestown, MA, 5 Massachusetts General Hospital, Boston,
MA, 6Massachusetts General Hospital.
26. Elevated Serum CX3CL1 Levels in Adult-Onset Still’s Disease:
Potential Involvement in Hemophagocytic Syndrome. Tsuyoshi
Kasama 1 , Kumiko Ohtsuka 2 , Michihito Sato 2 , Ryo Takahashi 2 ,
Kuninobu Wakabayashi 2 and Takeo Isozaki 2 , 1 Showa University
School of Med, Shinagawa-ku Tokyo, Japan, 2 Showa University
School of Med.
27. Gallic Acid Diminishes Cellular Proliferation and Pro-
Inflammatory Gene Expressions in Fibroblast Like Synoviocytes
from Patients with Rheumatoid Arthritis. Soo-Jin Chung 1 ,
Tae-Yeon Kim 2 , Yong-Jin Kwon 2 , Yong-Beom Park 2 , Soo-Kon Lee 2
and Min-Chan Park 3 , 1 Division of Rheumatology, Department of
Internal Medicine, Yonsei University College of Medicine, Seoul,
Republic of Korea, 2 Division of Rheumatology, Department of
Internal Medicine, Yonsei University College of Medicine, Seoul,
South Korea, 3 Division of Rheumatology, Yonsei University
College of Medicine, Seoul, Korea, Republic of.
28. WITHDRAWN
29. Interleukine 34 Is Expressed in the Synovial Tissue from OA
and RA Patients. Celine Cozic 1 , Benoit Le Goff 1 , Anne Riet 1 ,
Marie-Francoise Heymann 1 , Celine Charrier 1 , Regis Brion 1 ,
Sophie Touchais 3 , Marguerite Chemel 4 , Dominique Heymann 1
and Jean-Marie Berthelot 2 , 1 INSERM UMR S 957, 2 INSERM UMR
S 957 and Rheumatology Unit, CHU Nantes, Nantes, France,
3
Orthopedic Surgery Unit, CHU Nantes, 4 Rheumatology Unit,
CHU Nantes.
30. Oncostatin M, Acting through Oncostatin M Receptor, Is a
Potent Regulator of IL-6 and RANKL Expression in Mouse
Synovial Fibroblasts. Benoit Le Goff 3 , Narelle M. McGregor 1 ,
T. John Martin 2 , Evange Romas 1 , Natalie A. Sims 1 and Nicole
C. Walsh 1 , 1 St Vincent’s Institute, Fitzroy, VIC, Australia, 2 St
Vincent’s Institute, Fitzroy, Australia, 3 St Vincent’s Institute and
INSERM, UMR-S 957, Fitzroy, VIC, Australia.
31. Oral Bisphosphonates and Risk of Atypical Femur Fractures
in a Population-Based Cohort: A Propensity Score-Matched
Analysis. Seo Young Kim 2 , Sebastian Schneeweiss 3 , Jeffrey
N. Katz 1 , Raisa Levin 4 and Daniel H. Solomon 2 , 1 Brigham and
Women’s Hosp, Boston, MA, 2 Brigham and Women’s Hospital,
Boston, MA, 3 Brigham and Women’s Hospital, Boston, 4 Brigham
and Women’s Hospital.
2010 Program Book 149