B O O K - American College of Rheumatology

ACR/ARHP Poster Session C
Halls B1 & B2
WEDNESDAY, NOVEMBER 10, 2010
Biology and Pathology of Bone and Joint: Osteoarthritis-Cartilage
Degradation and Skeletal Turnover
1466. A Novel Serum Biomarker of Cartilage Destruction, Measured
in OA and RA Patients, Is Significantly Associated with
Kellgren-Lawrence Score. Anne C. Bay-Jensen 1 , Erik B. Dam 3 ,
Inger Byrjalsen 2 , Tanja Schubert 4 , Phillip Vergnaud 4 , Per Qvist 1
and Morten A. Karsdal 1 , 1 Cartilage Biology and Biomarkers,
Denmark, 2 CCBR-Synarc, Denmark, 3 Nordic Bioscience Imaging,
Denmark, 4 Synarc-Lyon, France.
1467. A Small Molecule c-Fos/AP-1 Inhibitor T-5224 Inhibits
Osteoclastogenesis and Bone Resorption. Hidetoshi Murao 3 ,
Yukihiko Aikawa 4 , Akira Hashiramoto 1 , Tetsuya Yamamoto 4 ,
Hisaaki Chaki 4 , Hirokazu Narita 4 , Shuichi Hirono 2 and Shunichi
Shiozawa 1 , 1 Department of Biophysics, Kobe University of
Graduate School of Health Sciences/The Center for Rheumatic
Diseases, Kobe University Hospital, Kobe, Japan, 2 Department
of Pharmaceutical Sciences, School of Pharmacy, Kitasato
University, Tokyo, Japan, 3 Research Laboratories, Toyama
Chemical Co., Ltd, Toyama, Japan, 4 Research Laboratories,
Toyama Chemical Co., Ltd, Toyama, Japan.
1468. Activation of Wnt and Bone Morphogenetic Protein Signalling
Pathways in the Articular Cartilage in Frzb-/- Mice. Liesbet
Lodewyckx 1 , Jeroen Eyckmans 3 , Frank P. Luyten 2 and Rik Lories 1 ,
1
KU Leuven, Leuven, Belgium, 2 KU Leuven, Leuven, Belgium, 3 KU
Leuven.
1469. Adenosine A1 Receptors Regulates RANKL-Induced Osteoclast
Formation Via Regulation of c-fos and NFATc1 Expression.
Wenjie He 2 , Tuere Wilder 2 and Bruce N. Cronstein 1 , 1 New York
Univ Med Ctr, New York, NY, 2 NYU School of Medicine.
1470. Adenosine A2A Receptor Agonists: Can They Prevent/
Treat Joint Prosthesis Loosening? Aranzazu Mediero 1 , Sally
R. Frenkel 2 , Tuere Wilder 1 , Igor Immerman 3 , Scott Hadley 3 ,
R. Damani Howell 3 , Maya Hawly 4 , Elie Sellam 4 and Bruce N.
Cronstein 5 , 1 Department of Medicine, NYU Langone Medical
Center, New York, NY, 2 Department of Orthopaedic Surgery,
NYU Hospital for Joint Diseases, New York, NY, 3 Department of
Orthopaedic Surgery, NYU Hospital for Joint Diseases, 4 Institut
Supérieur des BioSciences de Paris, France, 5 New York Univ Med
Ctr, New York, NY.
1471. Adenosine A2A Receptor Ligation Inhibits Osteoclast
Formation. Aranzazu Mediero 1 , Firas M. Kara 1 , Maya Hawly 2 ,
Elie Sellam 2 and Bruce N. Cronstein 3 , 1 Department of Medicine,
NYU School of Medicine, New York, NY, 2 Institut Supérieur des
Biosciences de Paris, Creteil, Ile de France, France, 3 New York
Univ Med Ctr, New York, NY.
1472. Alarmins S100A8 and S100A9 Skew Human Chondrocytes
towards a Cartilage Breakdown Phenotype. Rik F. P.
Schelbergen 4 , Peter L. van Lent 5 , Arjen B. Blom 5 , Annet Sloetjes 5 ,
Thomas Vogl 2 , Johannes Roth 1 and Wim B. Van Den Berg 3 ,
1
Children’s Hospital Eastern Ontario, Ottawa, ON, Canada,
2
Institute of Immunology, Muenster, 3 Radboud Univ Nijmegen
Med Cntr, Nijmegen, The Netherlands, 4 Radboud University
Nijmegen Medical Centre, Nijmegen, The Netherlands,
5
Radboud University Nijmegen Medical Centre.
1473. Analysis of Secretome from Mesenchymal Stem Cells from
Human Umbilical Cord Strome during the Chondrogenesis.
María C. Arufe 1 , Alexandre De la Fuente 2 , Jesús Mateos 4 ,
Patricia Fernández-Puente 4 , Esther Rendal 4 , Silvia Díaz 2 ,
Isaac Fuentes 2 , Francisco J. De Toro 2 and Francisco J. Blanco 3 ,
1
INIBIC-Universidad de A Coruna, A Coruna, Osteoarticular
and Aging Research Laboratory, Proteomics Unit-Associated
Node to ProteoRed-Biomedical Research Center (INIBIC),
Hospital Universitario A Coruna, La Coruna, Coruña, Spain,
2
INIBIC-Universidad de A Coruna, A Coruna, Spain, 3 INIBIC-
Universidad de A Coruna, A Coruna, Spain. Osteoarticular and
Aging Research Laboratory, Proteomics Unit-Associated Node
to ProteoRed-Biomedical Research Center (INIBIC). Hospital
Universitario A Coruna, La Coruna, Spain, 4 Osteoarticular and
Aging Research Laboratory, Proteomics Unit-Associated Node
to ProteoRed-Biomedical Research Center (INIBIC), Hospital
Universitario A Coruña. La Coruña, Spain.
1474. Biochemical Markers of Bone Balance (CTX-I/Osteocalcin)
Improve with Tocilizumab Treatment in a Population of RA
Patients with an Inadequate Response to Anti-TNF Therapy.
Morten Karsdal 2 , Thasia G. Woodworth 3 , Andy Kenwright 4 ,
Inger Byrjalsesn 1 , Adam Platt 4 and Georg Schett 5 , 1 CCBR Synarc,
Ballerup, Denmark, 2 Nordic Bioscience, Herlev, Herlev, Denmark,
3
Roche Products Ltd., Welwyn, Welwyn Garden City, United
Kingdom, 4 Roche, Welwyn, United Kingdom, 5 University of
Erlangen-Nuremberg, Erlangen, Germany.
1475. Chondrogenic Differentiation of Bone Marrow Mesenchymal
Stem Cells Grown on Type I Collagen and Heparan Sulfate
Scaffolds. Silvia Díaz-Prado 4 , Emma Muiños 3 , C. G. Trejo-
Iriarte 1 , D. Lozano 2 , N. García-Honduvilla 1 , Isaac Fuentes 3 ,
Francisco J. De Toro 3 , P. Esbrit 2 , Julia Buján 1 and Francisco J.
Blanco 3 , 1 Department of Medical Specialties. University of
Alcalá de Henares, Madrid, Spain, 2 Laboratory of Bone and
Mineral Metabolism. Fundación Jiménez Díaz (Capio Group).
Madrid, Spain, 3 Osteoarticular and Aging Res. Lab. CIBER-BBN,
Rheumatology Div, INIBIC-Complejo Hosp, Univ. A Coruña, A
Coruña, SPAIN, 4 Osteoarticular and Aging Res. Lab. CIBER-BBN.
Rheumatology Div. INIBIC-Complejo Hosp. Univ. A Coruña,
Coruña, Spain.
1476. CXCR1/2 Signalling Is Required but Is Not Sufficient To
Maintain the Phenotypic Stability of Human Articular
Chondrocytes. Joanna C. Sherwood 1 , Pramod Achan 2 , Giovanna
Nalesso 2 , Costantino Pitzalis 2 and Francesco Dell’Accio 2 , 1 Barts
and The London School of Medicine and Dentistry, Queen Mary
University of London, London, United Kingdom, 2 Barts and
The London School of Medicine and Dentistry, Queen Mary
University of London.
1477. Effects of NSAIDs and the Cyclooxygenase-Inhibiting Nitric
Oxide Donator (CINOD) NCX 429 on Human Chondrocytes and
Cartilage from OA Patients. Manlio Bolla 1 , Serena Viappiani 2 ,
Mandar Dave 4 , Jyoti Patel 4 , Steven B. Abramson 3 and Mukundan
Attur 3 , 1 NicOx Research, Sophia Antipolis, France, 2 NicOx
Research, 3 NYU Hospital for Joint Diseases, New York, NY, 4 NYU
Hospital for Joint Diseases.
1478. Endogeneous TIMP3 Induce Death Receptor Ligand-
Independent Apoptosis in Mesenchymal Cells. Christina
Wunrau 2 , Doreen Wendholt 3 , Noreen Pundt 3 , Thomas Pap 1 and
Berno Dankbar 3 , 1 IEMM, University Hospital Muenster, Münster,
Germany, 2 Institute of Experimental Musculoskeletal Medicine-
IEMM, University Hospital Muenster, Münster, Germany,
3
Institute of Experimental Musculoskeletal Medicine-IEMM,
University Hospital Muenster, Muenster, Germany.
2010 Program Book 233