B O O K - American College of Rheumatology

ACR/ARHP Poster Session B
1243 An Assessment of the Thromboembolic Potential of CDP7657,
a Monovalent Fab’ PEG Anti-CD40L Antibody, in Rhesus
Macaques. Ian Wakefield 2 , Olivier Harari 2 , David Hutto 1 , Linda
Burkly 1 , Janine Ferrant 1 , Fred Taylor 1 , Martyn Robinson 2 ,
Anthony Shock 2 , Timothy Bourne 2 and Christopher Peters 2 ,
1
Biogen Idec, 2 UCB.
1244. Blockade of CD40L with a Monovalent Fab’ PEG Monoclonal
Antibody Inhibits Disease in the Murine Collagen-Induced
Arthritis Model. Alexander Vugler 2 , Daniel Sutton 2 , Diane
Marshall 2 , Stevan Shaw 2 , Linda Burkly 1 , Janine Ferrant 1 , Ellen
Garber 1 and Anthony Shock 2 , 1 Biogen Idec, 2 UCB.
1245. CDP7657, a Monovalent Fab’ PEG Anti-CD40L Antibody,
Inhibits Immune Responses in Both HuSCID Mice and Non-
Human Primates. Ian Wakefield 2 , Christopher Peters 2 , Linda
Burkly 1 , Ellen Garber 1 , Janine Ferrant 1 , Fred Taylor 1 , Lihe Su 1 ,
Yen-Ming Hsu 1 , Martyn Robinson 2 , Timothy Bourne 2 , Roger
Palframan 2 , Lisa Berry 2 , Olivier Harari 2 and Anthony Shock 2 ,
1
Biogen Idec, 2 UCB.
1246. Characterization of Human Follicular Helper T Cells. Sang Taek
Kim 3 , Jin-Young Choi 4 , Begona Lainez 4 , Leah DiPlacido 1 , Vivian E.
Vlamakis 2 and Joseph E. Craft 4 , 1 Department of Immunobiology,
Yale University School of Medicine, New Haven, CT, 2 Division of
Rheumatology, University of Washington School of Medicine,
Bothell, WA, 3 Section of Rheumatology, Department of Internal
Medicine, Yale University School of Medicine, Orange, CT,
4
Section of Rheumatology, Department of Internal Medicine,
Yale University School of Medicine, New Haven, CT.
1247. Chronic Inflammatory Responses in Rheumatoid Arthritis:
The Vicious Circle Might Be Related to Interaction of Th17
Cells with FLS or Mesenchymal Stem Cells. Assia Eljaafari 1 ,
Marie-Laure Tartelin 1 and Pierre Miossec 2 , 1 HCL and UCBL, Lyon,
France, 2 HCL and UCBL, France.
1248. Circulating FOXP3+ CTLA-4+ CD25+ Regulatory T Cells in
Human Infants Counteract the Maturation and Homing
Receptor Switch of CD4+ T Cells at 18 and 36 Months of
Age. Hardis Rabe 2 , Anna-Carin Lundell 2 , Kerstin Andersson 2 ,
Ingegerd Adlerberth 1 , Agnes E. Wold 1 and Anna Rudin 3 , 1 Dept of
Clinical Bacteriology, 2 Dept of Rheumatology and Inflammation
Research, 3 Dept of Rheumatology and Inflammation Research,
The Sahlgrenska Academy at University of Gothenburg,
Gothenburg, Sweden.
1249. Critical Role of IL-21 in Modulating Th17 Responses and
Regulatory T Cells in Behçet Disease. Guillaume Geri 1 , Benjamin
Terrier 1 , Michelle Rosenzwajg 1 , Bertrand Wechsler 2 , Du Le
Boutin 1 , Bahram Bodaghi 1 , Tu-Ahn Tran 1 , Nathalie Costedoat-
Chalumeau 2 , Lucile Musset 1 , David Klatzman 1 , Patrice Cacoub 1
and David Saadoun 1 , 1 Pitié-Salpetrière Hospital, Paris, France,
2
Pitie-Salpetriére Hospital, Paris, France.
1250. CXCL13 Signals through CXCR5 To Upregulate Nuclear CXCR5
and Bcl-6 and Promote the Development of Follicular T Helper
Cells in Autoimmune BXD2 Mice. Yanna Ding 3 , Hui-Chen Hsu 1
and John D. Mountz 2 , 1 Department of Medicine, The University
of Alabama at Birmingham, 2 Department of Medicine, The
University of Alabama at Birmingham; Birmingham VA Medical
Center, 3 Department of Pathology, The Univerisity of Alabama at
Birmingham.
1251. Decreasing Fli1 Levels in Lupus T Cells Has Effects on Serum
Immunoglobulin Levels and T Cell Infiltration in the Kidney.
Erin Morris 1 , Maria I. Harrell 1 , John Svenson 1 , Laura Tonks 1 , John
Zhang 3 and Tamara K. Nowling 2 , 1 MUSC, 2 Ralph Johnson VAMC/
MUSC, Charleston, SC, 3 Ralph Johnson VAMC/MUSC.
1252. Dendritic Cells and Continued Smoking in Rheumatoid
Arthritis. Marina Kazantseva 3 , John Highton 1 , Lisa K. Stamp 4
and Paul A. Hessian 2 , 1 Univ of Otago Med Sch, Dunedin,
New Zealand, 2 University of Otago, Dunedin, New Zealand,
3
University of Otago, Dundein, New Zealand, 4 University of
Otago, Christchurch, New Zealand.
1253. DNA Methylation Affects Gene Expression in CD4+CD28- T
Cells through microRNAs. Dipak R. Patel, Anura Hewagama,
Sushma Yarlagadda and Bruce C. Richardson, University of
Michigan, Ann Arbor, MI.
1254. Dys-Regulation of T-Cell Subsets and Cytokines Is Associated
with the Development of Inflammatory Symptoms in ACPA-
Positive Asymptomatic Individual. Richard J. Cuthbert 2 , Rekha
Parmar 2 , Jackie Nam 2 , Edith Villeneuve 2 , Diane Corscadden 2 ,
Karen Henshaw 2 , Paul Emery 1 and Frederique Ponchel 2 , 1 Chapel
Allerton Hospital, Leeds, United Kingdom, 2 University of Leeds,
Leeds, UK.
1255. Expression of K2P5.1 Potassium Channels on CD4+ T
Lymphocytes Correlates with Disease Activity in Rheumatoid
Arthritis Patients. Martin Feuchtenberger 2 , Stefan Bittner 3 ,
Nicole Bobak 3 , Alexander M. Herrmann 3 , Kerstin Goebel 3 , Stefan
Kleinert 3 , Heinz Wiendl 1 , Hans-Peter Tony 3 and Sven G. Meuth 3 ,
1
University of Muenster, 2 University of Wuerzburg, Wuerzburg,
Germany, 3 University of Wuerzburg.
1256. Foxp3+ CD4+ Tregs Prevent Arthritis by Promoting Clonal
Anergy Induction in Self Ag-Specific CD4+ T Cells. Ryan
Martinez 2 , Na Zhang 2 , Sara Nandiwada 2 , Stephanie Thomas 2 ,
Bryce Binstadt 2 and Daniel L. Mueller 1 , 1 University of Minnesota
Medical School, Minneapolis, MN, 2 University of Minnesota
Medical School.
1257. Gender and Sex Hormones Influence CD4+ Regulatory T Cells
and Their Expression of FoxP3 in Healthy People and in SLE.
Ravi K. Dinesh 1 , Bevra H. Hahn 2 and Ram P. Singh 1 , 1 David Geffen
Schl of Med/UCLA, Los Angeles, CA, 2 University of California Los
Angeles School of Medicine, Los Angeles, CA.
1258. Identification of a Pathological TCR of Autoantibody-Inducing
CD4+ T Cell That Induces Autoantibodies and Lupus-Like
Immune Tissue Injury. Kohsuke Yoshida 1 , Ken Tsumiyama 2 and
Shunichi Shiozawa 3 , 1 Department of Biophysics, Kobe University
Graduate School of Health Sciences, Kobe, Hyogo, Japan,
2
Department of Biophysics, Kobe University Graduate School of
Health Sciences, Kobe, Japan, 3 Department of Biophysics, Kobe
University Graduate School of Health Sciences/Department of
Medicine, Kobe University Graduate School of Medicine/The
Center for Rheumatic Diseases, Kobe University Hospital, Kobe,
Japan.
1259. IL-23 Suppresses IL-22 Levels and AHR Expression in Human
CCR6+ Memory T Cells. Ferry Cornelissen, Jan Piet van
Hamburg, Nadine Davelaar, Patrick Asmawidjaja, Anne-Marie
Mus and Erik Lubberts, Erasmus MC, University Medical Center.
1260. IL-23-Mediated RORγt Pathway Is Associated with Thymic
Negative Selection of Autoreactive T Cells. Hao Li 2 , Hui-Chen
Hsu 2 , Qi Wu 2 , PingAr Yang 2 , Jun Li 2 and John D. Mountz 1 , 1 Univ
Alabama at Birmingham, Birmingham, AL, 2 Univ Alabama at
Birmingham.
1261. Immune Regulation by Peripheral Suppressor T Cells Induced
upon Homotypic T Cell Interaction. Katja Thuemmler 1 , Leipe
Jan 1 , Andreas Ramming 1 , Hendrik Schulze-Koops 2 and Alla
Skapenko 1 , 1 Division of Rheumatology, LMU Munich, Munich,
Germany, 2 LMU Munich, Munich, Germany.
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2010 Program Book