B O O K - American College of Rheumatology

ACR Poster Session A
609. Mice Lacking the Receptor-Like Protein Tyrosine Phosphatase
CD148 Are Protected from Bleomycin-Induced Pulmonary
Fibrosis. Tamiko R. Katsumoto 1 , Kevin K. Kim 2 , Alexis N.
Brumwell 2 , John X. Nguyen 2 , Jing W. Zhu 2 , Mark R. Looney 2 ,
Harold A. Chapman 2 and Arthur Weiss 2 , 1 UCSF, South San
Francisco, CA, 2 UCSF.
610. Noggin +/LacZ Heterozygous Mice Have Reduced Pulmonary
Fibrosis in the Bleomycin Induced Model. Ellen de Langhe 2 ,
Vanessa De Vooght 2 , Frank P. Luyten 1 and Rik Lories 1 , 1 KU
Leuven, Leuven, Belgium, 2 KU Leuven.
611. Nr4a1 Ameliorates the Pro-Fibrotic Effects of TGFβ in Systemic
Sclerosis (SSc) and Might Be an Interesting Target for Anti-
Fibrotic Therapies. Katrin Palumbo 1 , Alfiya Akhmetshina 1 ,
Pawel Zerr 1 , Michal Tomcik 1 , Angelika Horn 1 , Clara Dees 1 , Oliver
Distler 3 , Georg Schett 2 and Jorg H. W. Distler 4 , 1 Department
of Internal Medicine III and Institute for Clinical Immunology,
University of Erlangen-Nuremberg, Erlangen, Germany,
2
Friedrich Alexander Univ, Erlangen, Germany, 3 University
Hospital Zurich, Zurich, Switzerland, 4 University of Erlangen,
Erlangen, Germany.
612. Osteopontin in Systemic Sclerosis and Its Role in Dermal
Fibrosis. Minghua Wu 2 , Daniel J. Schneider 1 , Maureen D.
Mayes 3 , Shervin Assassi 2 , Frank C. Arnett 4 , Filemon K. Tan 5 ,
Michael R. Blackburn 1 and Sandeep K. Agarwal 2 , 1 Department
of Biochemistry and Molecular Biology, UTHSC-H, Houston,
TX, 2 Division of Rheumatology and Clinical Immunogenetics,
University of Texas Health Science Center at Houston, Houston,
TX, 3 University of Texas-Houston, Houston, TX, 4 UT Medical
School, Houston, TX, 5 UT-Houston Med School, Houston, TX.
613. Relevance of Epithelial Phenotypic Switching in the
Pathogenesis of Systemic Sclerosis. Xu Shiwen 1 , S. Sonnylal 3 ,
A. Tam 2 , R. Stratton 2 , A. Leask 2 , C. P. Denton 2 , J. Norman 2
and D. Abraham 2 , 1 Rheumatology, London, United Kingdom,
2
Rheumatology,, United Kingdom, 3 UT M. D. Anderson Cancer,
Houston, TX.
614. S100A4 as a Novel Mediator of TGF-β Driven Dermal Fibrosis
in Systemic Sclerosis. Michal Tomcik 4 , Pawel Zerr 2 , Katrin
Palumbo 2 , Barbara G. Fürnrohr 2 , Jerome Avouac 3 , Angelika
Horn 2 , Clara Dees 2 , Alfiya Akhmetshina 2 , Christian Beyer 2 ,
Radim Becvar 7 , Oliver Distler 1 , Mariam Grigorian 6 , Ladislav
Senolt 7 , Georg Schett 5 and Jorg H. W. Distler 8 , 1 Center of
Experimental Rheumatology and Zurich Center of Integrative
Human Physiology, University Hospital Zurich, Switzerland,
2
Department of Internal Medicine III and Institute for
Clinical Immunology, University of Erlangen-Nuremberg,
Erlangen, Germany, 3 Department of Internal Medicine III
and Institute for Clinical Immunology, University of Erlangen-
Nuremberg, Erlangen, Germany and Paris Descartes University,
Rheumatology A Department Cochin Hospital, Paris, France,
4
Department of Internal Medicine III, University of Erlangen-
Nuremberg, Erlangen, Germany and Institute of Rheumatology
and Connective Tissue Research Laboratory, Department
of Rheumatology of the First Faculty of Medicine, Charles
University i, 5 Friedrich Alexander Univ, Erlangen, Germany,
6
Institute of Cancer Biology, Danish Cancer Society, Copenhagen,
Denmark, 7 Institute of Rheumatology and Connective Tissue
Research Laboratory, Department of Rheumatology of the
First Faculty of Medicine, Charles University in Prague, Czech
Republic, 8 University of Erlangen, Erlangen, Germany.
615. The Synthetic Cannabinoid Ajulemic Acid Targets
Scleroderma Fibrosis. Estrella Garcia Gonzalez 3 , Enrico Selvi 2 ,
Balistreri Epifania 3 , Alfiya Akhmetshina 1 , Sauro Lorenzini 3 ,
Kathrin Palumbo 1 , Mauro Galeazzi 3 and Jorg W. H. Distler 1 ,
1
Departement of Internal Medicine III and Institute for Clinical
Immunology -Friedrich-Alexander University-Erlangen-Germany,
2
Rheumatology Unit - Departement of Clinical Medicine and
Immunological Sciences-University of Siena, Siena, Italy,
3
Rheumatology Unit - Departement of Clinical Medicine and
Immunological Sciences-University of Siena- Italy.
616. The Transcription Factor AP-1 Mediates the Pro-Fibrotic Effects
of TGFβ and Contributes to the Development of Experimental
Dermal Fibrosis. Jerome Avouac 3 , Katrin Palumbo 2 , Michal
Tomcik 4 , Pawel Zerr 2 , Clara Dees 2 , Angelika Horn 2 , Alfiya
Akhmetshina 2 , Christian Beyer 2 , Shunichi Shiozawa 5 , Oliver
Distler 1 , Georg Schett 6 , Yannick Allanore 7 and Jorg H. W. Distler 8 ,
1
Center of Experimental Rheumatology and Zurich Center of
Integrative Human Physiology, University Hospital Zurich, Zurich,
Switzerland, 2 Department of Internal Medicine III and Institute
for Clinical Immunology, University of Erlangen-Nuremberg,
Erlangen, Germany, 3 Department of Internal Medicine III
and Institute for Clinical Immunology, University of Erlangen-
Nuremberg, Erlangen, Germany, Paris Descartes University,
Rheumatology A Department, Cochin Hospital and INSERM U 781 ,
Necker Hospital, Paris, Fra, 4 Department of Internal Medicine
III, University of Erlangen-Nuremberg, Erlangen, Germany and
Institute of Rheumatology and Connective Tissue Research
Laboratory, Department of Rheumatology of the First Faculty
of Medicine, Charles University i, 5 Division of Rheumatology,
Department of Medicine, Kobe University Graduate School of
Medicine, Kobe University Hospital, Kobe, Japan, 6 Friedrich
Alexander Univ, Erlangen, Germany, 7 Paris Descartes University,
Rheumatology A Department, Cochin Hospital and INSERM
U781, Necker Hospital, Paris, France, 8 University of Erlangen,
Erlangen, Germany.
617. The Triterpenoid CDDO Abrogates Canonical TGF-beta
Signaling and Fibrotic Responses in Normal and Scleroderma
Fibroblasts by Stabilizing the Anti-Oxidant Nuclear Factor-
Like 2 (Nrf2). Kazuhiro Komura 2 , Jun Wei 2 , Gabriel Lord 2 and
John Varga 1 , 1 Northwestern Univ Feinberg School, Chicago, IL,
2
Northwestern University Feinberg School of Medicine.
618. Urantide Prevents and Alleviates Monocrotaline Induced
Pulmonary Arterial Hypertension in Wistar Rats. Yifang
Mei 1 , Hong Jin 3 , Hao Wang 2 , Wei Tian 2 , Yanping Zhao 2 and
Zhiyi Zhang 2 , 1 The First Affiliated Hospital of Harbin Medical
University, Harbin, Heilongjiang, China, 2 The First Affiliated
Hospital of Harbin Medical University, Harbin, China, 3 The
First Affiliated Hospital of Shantou University Medical College,
Shantou, China.
619. Visfatin/NAMPT in Interstitial Pneumonia of Patients with
Systemic Sclerosis and Scleroderma Mice Model Induced
by Bleomycin. Hirahito Endo 2 , Tatsuhiro Yamamoto 1 , Kaichi
Kaneko 3 , Yoshie Kusunoki 3 , Natsuko Kusunoki 3 and Shinichi
Kawai 3 , 1 Division of Rheumatology, Department of Internal
Medicine, Toho University School of Medicine, Ohmori-nishi,
Ohta-ku, Japan, 2 Division of Rheumatology, Department of
Internal Medicine, Toho University School of Medicine, Ohmorinishi,
Oh-taku, Japan, 3 Division of Rheumatology, Department of
Internal Medicine, Toho University School of Medicine.
190
2010 Program Book