B O O K - American College of Rheumatology

ACR/ARHP Poster Session B
848. Cellular Immunity in Rheumatoid Arthritis Patients Not
Responding to Synthetic DMARDs. Andra Balanescu 3 , Ionela
Victoria Neagoe 5 , Florian Berghea 3 , Carolina Negrei 2 , Magda
Parvu 1 , Ruxandra Ionescu 4 , Denisa Predeteanu 4 , Violeta
Bojinca 4 , Vasile Preoteasa 6 and Gina Manda 6 , 1 Colentina Clinical
Hospital, Bucharest, Romaia, 2 Department of Toxicology,
University of Medicine and Pharmacy Carol Davila, Bucharest,
Romania, 3 Research Center of Rheumatic Diseases, Sf. Maria
Hospital, University of Medicine and Pharmacy Carol Davila,
Bucharest, Romania, 4 Research Center of Rheumatic Diseases,
Sf. Maria Hospital, University of Medicine and Pharmacy Carol
Davila, Bucharest, Romania, 5 Victor Babes National Institute of
Pathology, Bucharest, Romania, 6 Victor Babes National Institute
of Pathology, Bucharest, Romania.
849. Comprehensive Flow Cytometric Profiling of Peripheral
Blood Dendritic Cells in Rheumatoid and Psoriatic Arthritis
Patients. James Kobie 6 , Ben Panepento 6 , Jyh-Chiang E. Wang 6 ,
Grace Chiu 6 , Darren Tabechian 8 , Allen P. Anandarajah 2 , Richard
J. Looney 3 , Ralf G. Thiele 5 , Jennifer H. Anolik 1 , Ignacio Sanz 4 ,
Sally Quataert 6 , Alex Rosenberg 6 and Christopher T. Ritchlin 7 ,
1
University of Rochester, Rochester, NY, 2 Univ of Rochester
Med Ctr, Rochester, NY, 3 University of Rochester, Rochester, NY,
4
University of Rochester, Rochester, NY, 5 University of Rochester,
Rochester, NY, 6 University of Rochester, 7 University of Rochester
Medical Center, Rochester, NY, 8 University of Rochester School
of Medicine, Rochester, NY.
850. C-Reactive Protein Inhibition of the Response to Type I
Interferon (IFN). Carolyn Mold 2 , Daniel Goldberg 1 , Carol Morris 1
and Terry Du Clos 1 , 1 University of New Mexico, 2 University of
New Mexico, Albuquerque, NM.
851. Endosomal Trafficking of Antigen in Antigen Cross-Presentation
and the Cause of Lupus Tissue Injuries. Mai Takimoto 1 , Ken
Tsumiyama 1 and Shunichi Shiozawa 2 , 1 Department of Biophysics,
Kobe University Graduate School of Health Sciences, Kobe,
Japan, 2 Department of Biophysics, Kobe University Graduate
School of Health Sciences/Department of Medicine, Kobe
University Graduate School of Medicine/The Center for
Rheumatic Diseases, Kobe University Hospital, Kobe, Japan.
852. Exposure to U1-RNP Components Induces Bone Marrow-
Derived Dendritic Cell Trafficking to the Lung. Luis Sorell 4 ,
YunJuan Zang 4 , Irina Fernandez 4 , Laisel Martinez 1 , Maria
Carpintero 3 and Eric L. Greidinger 2 , 1 Miami VA Medical Center,
2
Miami VA Medical Center and University of Miami Miller School
of Medicine, Miami, FL, 3 University of Miami Miller School
of Medicine, Pembroke Pines, FL, 4 University of Miami Miller
School of Medicine.
853. Fas Expression in Myeloid Cells Is Required To Prevent
Systemic Autoimmunity. Carla M. Cuda 1 , Hemant Agrawal 1 ,
Evan Weber 2 , G. Kenneth Haines 3 and Harris R. Perlman 1 ,
1
Northwestern University, Chicago, IL, 2 Northwestern University,
3
Yale University.
854. FLIP: The Novel Regulator of Macrophage Differentiation
and Granulocyte Homeostasis. Qi Quan Huang 2 , Harris R.
Perlman 2 , Zan Huang 3 , Robert Birkett 3 , John D. Crispino 3 and
Richard M. Pope 1 , 1 Northwestern Univ Med School, Chicago, IL,
2
Northwestern University, Chicago, IL, 3 Northwestern University.
855. IкB Kinase (IKK)ε: Bridging Innate and Adaptive Immunity in
Collagen-Induced Arthritis (CIA). Deepa Hammaker 2 , Katharyn
Topolewski 3 , David L. Boyle 1 and Gary S. Firestein 1 , 1 UCSD School
of Medicine, La Jolla, CA, 2 Univ of California San Diego, La Jolla,
CA, 3 University of California, San Diego.
856. IMO-3100, a Toll-Like Receptor (TLR) Antagonist, Suppresses
TLR7- and TLR9-Mediated Immune Responses in Non-
Human Primates. Lakshmi Bhagat 2 , Jimmy X. Tang 2 , Tim
Sullivan 2 , Ekambar R. Kandimalla 1 and Sudhir Agrawal 2 , 1 Idera
Pharmaceuticals, Inc, Cambridge, MA, 2 Idera Pharmaceuticals,
Inc.
857. Involvement of Toll-Like Receptor 2 in Pristane-Induced Lupus.
Vilma Urbonaviciute 3 , Silke Frey 2 , Carsten Kirschning 1 , Georg
Schett 2 and Reinhard E. Voll 2 , 1 Essen, Germany, 2 Erlangen,
Germany, 3 Department Internal Medicine 3 , University Hospital
Erlangen, University of Erlangen-Nuremberg, Erlangen,
Germany.
858. Mir-19b Regulates TLR2 Expression in Rheumatoid Arthritis
Fibroblast-Like Synoviocytes. Lucas Philippe 3 , Guillaume
Suffert 1 , Ghada Alsaleh 3 , Arnaud Theulin 3 , Jacques Eric
Gottenberg 3 , Jean Sibilia 3 , Sebastien Pfeffer 2 and Dominique
Wachsmann 3 , 1 Architecture et Réactivité de l’ARN, Université
de Strasbourg, Institut de Biologie Moléculaire et Cellulaire
du CNRS, Strasbourg, France, Metropolitan, 2 Architecture
et Reactivite de l’ARN, Universite de Strasbourg, Institut de
Biologie Moleculaire et Cellulaire du CNRS, Strasbourg, France,
Metropolitan, 3 Laboratoire de Physiopathologie des Arthrites,
EA4438, Faculté de Pharmacie, 74 Route du Rhin, Illkirch-
Graffenstaden, France, Metropolitan.
859. Myeloid but Not Lymphoid Bim Expression Is Required
Suppress SLE-Like Disease. Hemant Agrawal 1 , Evan Weber 1 ,
Alexander Misharin 1 , Carla M. Cuda 1 , G. Kenneth Haines 2 ,
Rosalind Ramsey-Goldman 1 and Harris Perlman 1 , 1 Dept Med/Div
Rheumatology, Northwestern University, 2 Yale University.
860. Natural Killer (NK) Cells Resident in Normal Human Skin Are
Distinct from Blood and Lung NK Cells. Ahmed Gehad 1 , Sandra
King 1 and Robert Fuhlbrigge 2 , 1 Brigham and Women’s Hospital,
2
Children’s Hospital- Boston, Boston, MA.
861. p21 Suppression of Inflammatory Arthritis Requires the PCNA
Domain and Inhibition of p38. Angelica K. Gierut 1 , Melissa
Mavers 3 , Carla M. Cuda 2 , Alexander Misharin 2 , Evan Weber 2
and Harris R. Perlman 1 , 1 Northwestern University, Chicago, IL,
2
Northwestern University, 3 St. Louis University.
862. Peripheral Blood Mononuclear Cells and Plasmacytoid
Dendritic Cells from Healthy Human Females Exhibit Altered
TLR7-Mediated Immune Responses Compared to Males.
Melissa Precopio 1 , Dong Yu 2 , Ekambar R. Kandimalla 2 and
Sudhir Agrawal 2 , 1 Idera Pharmaceuticals, Cambridge, MA, 2 Idera
Pharmaceuticals.
863. Post-Translational Control Mechanisms Regulate Dendritic Cell
Activation of T Cell Responses. Dana Orange 1 , Jak Fak 2 , Nathalie
Blachere 2 and Robert Darnell 2 , 1 The Hospital for Special Surgery,
2
The Rockefeller University.
864. Reduced T-Cell-Dependent Humoral Immune Response in
Microsomal Prostaglandin E Synthase-1 Null Mice. Rahul G.
Matnani 2 , Fumiaki Kojima 2 , Jerold G. Woodward 2 and Leslie J.
Crofford 1 , 1 Univ of KY, Lexington, KY, 2 Univ of KY.
865. Regulation of VLA-4 in SLE Monocytes. Homaira Rahimi 1
and Kathleen E. Sullivan 2 , 1 Children’s Hosp Philadelphia,
Philadelphia, PA, 2 Childrens Hosp of Philadelphia, Philadelphia,
PA.
866. The Cholinergic Anti-Inflammatory Pathway as a Modulator
of Immune Complex-Induced Acute Inflammation. Milena
Vukelic 2 , Gloria Koo 2 and Jane E. Salmon 1 , 1 Hospital for Special
Surgery, New York, NY, 2 Hospital for Special Surgery, New York,
NY.
2010 Program Book 199