B O O K - American College of Rheumatology

ACR/ARHP Poster Session B
833. IL13 Is a Risk Locus for Psoriatic Arthritis but Not Psoriasis
Vulgaris. John Bowes 1 , Pauline Ho 2 , Salma Salah 1 , Richard
B. Warren 5 , Eleanor Korendowych 7 , Neil McHugh 7 , Oliver
FitzGerald 4 , Jonathon Packham 3 , Ann W. Morgan 6 , Christopher
E. M. Griffiths 5 , Ian N. Bruce 2 , Jane Worthington 1 and
Anne Barton 2 , 1 Arthritis Research UK Epidemiology Unit,
The University of Manchester, UK, 2 Arthritis Research UK
Epidemiology Unit, The University of Manchester, UK; The
Kellgren Centre for Rheumatology, Manchester, UK, 3 Arthritis
Research UK, National Primary Care Centre, Keele University
UK, 4 Department of Rheumatology, University College Dublin,
Ireland, 5 Dermatological Sciences, The University of Manchester,
UK., 6 NIHR-Leeds Musculoskeletal Biomedical Research Unit,
University of Leeds, UK, 7 Royal National Hospital for Rheumatic
Diseases.
834. Major Differences among Proteomes of Macro-Vascular and
Micro-Vascular Endothelial Cells: 2D-DIGE Approach. Hanadi
Dib 1 , Philippe Chafey 3 , Guilhem Clary 3 , Morgane Le Gall 3 ,
Cedric Broussard 4 , Luc Camoin 4 , Christian Federici 3 , Veronique
Witko-Sarsat 3 , Mathieu C. Tamby 3 and Luc Mouthon 2 , 1 INSERM
1016, Cochin Institute, Paris Descartes University, Paris, France,
2
INSERM 1016, Cochin Institute, Paris Descartes University,
Paris, France, 3 INSERM 1016, Cochin Institute, Paris, France,
4
Proteomics Platform of Paris Descartes, Paris, France.
835. mtDNA Haplogroups Define Two Phenotypes of Osteoarthritis
(OA). Ignacio Rego-Pérez 4 , Mercedes Fernández-Moreno 5 , M.
Deberg 1 , Sonia Pértega 3 , Carlos Fernández-López 5 , Natividad
Oreiro 5 , Manuel Acasuso 2 , Victoria Bonome-González 2 , Y.
Henrotin 1 and Francisco J. Blanco 5 , 1 Bone and Cartilage
Res. Unit. Univ. of Liege, Liege, Belgium, 2 Centro de Salud
Matogrande - SERGAS, A Coruña, Spain, 3 Epidemiology Unit.
INIBIC-Complejo Hosp. Univ. A Coruna, A Coruna, Spain,
4
Osteoarticular and Aging Res. Lab. Rheumatology Div, INIBIC-
Complejo Hosp, Univ. A Coruña, Coruña, Spain, 5 Osteoarticular
and Aging Res. Lab. Rheumatology Div, INIBIC-Complejo Hosp,
Univ. A Coruña, A Coruña, Spain.
836. Neurotransmitter Receptor Gene Polymorphisms Are
Associated with Widespread Pain: Findings from the First
Genome-Wide Association Study of Musculoskeletal Pain. Kate
L. Holliday 3 , Tuhina Neogi 2 , David Felson 2 , Ke Wang 1 , Wendy
Thomson 4 and John McBeth 4 , 1 Boston Univerity School of Public
Health, 2 Boston University School of Medicine, 3 University
of Manchester, Manchester, United Kingdom, 4 University of
Manchester.
837. Pathogenesis of Idiopathic Recurrent Pericarditis and Role of
the TNFRSF1A Gene Mutations. Luca Cantarini, Orso Maria
Lucherini, Maria Giuseppina Brizi and Mauro Galeazzi, Unit of
Rheumatology, University of Siena, Siena, Italy.
838. Radiographic Kellgren-Lawrence (KL) Grade 1 Is Genetically
Distinct from KL 0: Implications for Genetic Studies of Knee
Osteoarthritis (OA). Venkateswarlu Kondragunta 3 , Xiaodong
Wu 3 , Jordan B. Renner 2 , Gordon W. Duff 4 , Kenneth S. Kornman 3
and Joanne M. Jordan 1 , 1 Chapel Hill, NC, 2 Department of
Radiology and Thurston Arthritis Research Center, University of
North Carolina at Chapel Hill, 3 Interleukin Genetics, Inc., 4 School
of Medicine, University of Sheffield.
839. Salivary Proteomic Profile in Behçet’s Disease. Rosaria
Talarico, Chiara Baldini, Laura Giusti, Ylenia Da Valle, Camillo
Giacomelli, Elena Donadio, Francesca Sernissi, Anna d’Ascanio,
Laura Bazzichi, Antonio Lucacchini and Stefano Bombardieri,
Rheumatology Unit, Department of Internal Medicine,
University of Pisa, Pisa, Italy.
840. Study of the Chondrogenic Differentiation Process by
Metabolic Labeling of Mesenchymal Stem Cells. Beatriz Rocha 1 ,
Valentina Calamia 2 , Patricia Fernández-Puente 2 , Jesús Mateos 2 ,
Cristina Ruiz-Romero 2 and Francisco J. Blanco 2 , 1 Osteoarticular
and Aging Research Lab, Proteomics Unit, Nodo Asociado
de ProteoRed. INIBIC-Complejo Hospitalario Universitario A
Coruña, A Coruña, Coruña, Spain, 2 Osteoarticular and Aging
Research Lab, Proteomics Unit, Nodo Asociado de ProteoRed.
INIBIC-Complejo Hospitalario Universitario A Coruña, A Coruña,
Spain.
841. The FAAH Gene Is Involved in Risk of Symptomatic
Osteoarthritis of the Knee and in Pain in Osteoarthritis. Ana
M. Valdes 1 , Anne-Marie Malfait 3 , Sally Doherty 5 , Rosalina Das 4 ,
Margaret Wheeler 5 , Deborah Hart 2 , Tim D. Spector 2 , Cyrus
Cooper 6 , Michael Doherty 5 and Nigel K. Arden 6 , 1 King’s College
London, London, United Kingdom, 2 King’s College London, 3 Rush
University Medical Center, Chicago, IL, 4 Rush University Medical
Center, 5 University of Nottingham, United Kingdom, 6 University
of Southampton - University of Oxford, United Kingdom.
842. The Profile of miRNA Expression during the Differentiation of
Murine Osteoclast. Inhye E. Ahn 1 , Ji Hyeon Ju 2 and Jin Sil Park 3 ,
1
Department of Internal Medicine, The Methodist Hospital,
Houston, TX, 2 Division of Rheumatology, Department of Internal
Medicine, Catholic University of Korea, Seoul, Korea, Republic
of, 3 Rheumatology Research Center, Catholic University of
Korea, Seoul, Korea, Republic of.
843. Towards Allele-Specific Dynamic Proteomics: Measuring
Protein Synthesis and Turnover Using Heavy Water Labelling
and Peptide Mass Spectrometry. Michael J. Deery 1 , Alessandra
De Riva 2 , Claudia Prevosto 2 , Sarah McDonald 2 and Robert
Busch 2 , 1 Centre for Proteomics, University of Cambridge, 2 Dept
of Medicine, University of Cambridge.
Innate Immunity and Rheumatic Disease
844. β2 Integrins Control the Pro-Inflammatory Phenotype of Type
1 Macrophages and Dendritic Cells. Kim C. M. Santegoets 2 ,
Mark H. Wenink 2 , Richard Huijbens 2 , Lenny van Bon 2 , Alessandra
Cambi 2 , Piet L. Van Riel 3 , Wim B. Van Den Berg 1 and Timothy R.
D. J. Radstake 2 , 1 Radboud Univ Nijmegen Med Cntr, Nijmegen,
The Netherlands, 2 Radboud University Nijmegen Medical
Center, 3 University Hosp Nijmegen, Nijmegen, The Netherlands.
845. “Alarmins”S100A8 and A9 Are Expressed in Synovium of
Early OA Patients and Regulate Synovial Activation and
Joint Destruction during Experimental Osteoarthritis. Peter
van Lent 1 , Arjen Blom 1 , Rik Schelbergen 1 , Annet Sloetjes 1 ,
Thomas Vogl 2 , Johannes Roth 2 and Wim van den Berg 1 , 1 Dep
of Rheumatology University Hospital Nijmegen Medical
Centre, Nijmegen, Gelderland, The Netherlands, 2 Institute of
Immunology Muenster, Muenster, Germany.
846. Altered T Cell Signaling in Systemic Lupus Erythematosus (SLE):
A Role for FcγRIII and Immune Complexes (ICs). Anil Chauhan 1 ,
John P. Atkinson 3 and Terry L. Moore 2 , 1 Saint Louis University,
Saint Louis, MO, 2 St Louis University, St Louis, MO, 3 Washington
University School of Medicine, St Louis, MO.
847. C5aR Is Expressed by Macrophages and Dendritic Cells in
Close Proximity to T-Cells in Synovial Tissue from Patients
with Rheumatoid Arthritis. Ditte Tornehave 1 and Lars
Hornum 2 , 1 Histology, Biopharmaceuticals Research Unit,
Novo Nordisk A/S, Måløv, Denmark, 2 Immunopharmacology,
Biopharmaceuticals Research Unit, Novo Nordisk A/S, Måløv,
Måløv, Denmark.
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2010 Program Book