B O O K - American College of Rheumatology

ACR/ARHP Poster Session B
1262. Late Complement Complex in T Cell Function and Cell Death.
Anil Chauhan 1 , John P. Atkinson 3 and Terry L. Moore 2 , 1 Saint
Louis University, 2 St Louis University, St Louis, MO, 3 Washington
University School of Medicine, St Louis, MO.
1263. Linking Power Doppler Ultrasound with Th17 Cells in the RA
Joint. Nicola J. Gullick 1 , Hayley G. Evans 2 , Leigh Church 3 , David
Jayaraj 2 , Andrew Filer 3 , Bruce W. Kirkham 4 and Leonie S. Taams 2 ,
1
CMCBI, King’s College London, London, United Kingdom,
2
CMCBI, King’s College London, 3 Rheumatology Research Group,
University of Birmingham, 4 Rheumatology, Guy’s& St Thomas’
NHS Foundation Trust.
1264. NKT Cell Is Required for the Break of T Cell Anergy, Inducing
Autoantibody, and Generation of Autoantibody-Inducing CD4+
T Cell That Causes Systemic Autoimmunity. Yuko Fujita 1 , Ken
Tsumiyama 2 and Shunichi Shiozawa 3 , 1 Depertment of Biophysics,
Kobe University Graduate School of Health Science, Kobe,
Japan, 2 Depertment of Biophysics, Kobe University Graduate
School of Health Science, Kobe, Japan, 3 Depertment of
Biophysics, Kobe University Graduate School of Health Science/
Depertment of Medicine, Kobe University Graduate School of
Medicine/ The Center for Rheumatic Diseases, Kobe University
Hospital, Kobe, Japan.
1265. Peroxisome Proliferator-Activated Receptor α and γ Agonists
Together with TGF-β Convert Human CD4+CD25- T Cells into
Functional Foxp3+ Regulatory T Cells. Hitoshi Hasegawa 1 ,
Jin Lei 2 , Takuya Matsumoto 2 and Masaki Yasukawa 2 , 1 Ehime
University Graduate School of Medicine, Toon, Ehime, Japan,
2
Ehime University Graduate School of Medicine.
1266. Phenotype and Functional Stability of TGF-β-Induced
CD4+Foxp3+ Regulatory T Cells in Steady and Inflammatory
States. NIng Kong 3 , Julie Wang 3 , David Brand 4 , Hejian Zou 1 ,
Xuezhong Yu 2 and Song Guo Zheng 3 , 1 Fudan University Medical
School, 2 H. Lee Moffitt Cancer Center and Research Institute,
3
USC Keck School of Medicine, 4 VA Medical Center, Memphis.
1267. Plasmacytoid Dendritic Cells Control Peripheral Treg
Conversion to the RNA-Binding Nuclear Self Antigen La/SS-B.
A. Darise Farris 1 , Christina Lawrence 2 and Zi-jian Pan 2 , 1 Arthritis
and Immunology Program, Oklahoma Medical Research
Foundation, Oklahoma City, OK, 2 Oklahoma Medical Research
Foundation, Oklahoma City, OK.
1268. Protective Human CD4+CD25+FOXP3+ Regulatory T Cells
Generated Ex-Vivo with IL-2, Retinoic Acid and TGF-bets Are
Resistant to Pro-Inflammitory Cytokines. Xiaohui Zhou 1 , Chin
Lan 1 , Juhua Wang 1 , Song-guo Zheng 1 and David A. Horwitz 2 ,
1
University of Southern California, 2 University of Southern
California, Los Angeles, CA.
1269. RANKL Expression in Human T-Lymphocytes Requires
Cooperative Signaling through the T-Cell Receptor and
Adhesion Molecule CD2. Bohdan P. Harvey and Zehra
Kaymakcalan, Abbott Laboratories, Worcester, MA.
1270. Regulation of Human T Cell Activation and Effector Functions
by Kv1.3 and KCa3.1 Channels. Gang Chen 1 , Vaishali Patel 1 ,
Rothschild Soto 2 , Chen Shiow-Ling 2 , Sandip Panicker 2 , Philip
A. Nunn 2 and Julie A. DeMartino 2 , 1 Inflammation Discovery,
Hoffmann-La Roche, Inc., Nutley, NJ, 2 Inflammation Discovery,
Hoffmann-La Roche, Inc..
1271. Role for IL-23 in Differentiation of Human Th17 Cells. Hiroshi
Kato 1 , Laura Cooney 2 , Judith Endres 2 and David A. Fox 3 ,
1
University of Michigan, Northville, MI, 2 University of Michigan,
Ann Arbor, MI, 3 University of Michigan Medical Center, Ann
Arbor, MI.
1272. Self-Organized Criticality Theory for the Cause of
Autoimmunity. Ken Tsumiyama 1 , Yumi Miyazaki 1 and Shunichi
Shiozawa 2 , 1 Department of Biophysics, Kobe University
Graduate School of Health Science, Kobe, Japan, 2 Department of
Biophysics, Kobe University Graduate School of Health Science/
Department of Medicine, Kobe University Graduate School of
Medicine/The Center for Rheumatic Diseases, Kobe University
Hospital, Kobe, Japan.
1273. SGN-70: Phase 1a Study of a Novel Humanized Antibody
Targeting CD70 for the Treatment of Autoimmune Diseases.
Jonathan G. Drachman 2 , Julie A. McEarchern 2 , Che-Leung Law 2 ,
Luis Lopez-Lazaro 1 , Gabriele Fabian 1 and Michael Seiberling 1 ,
1
Covance Clinical Research Unit AG, Basel, Switzerland, 2 Seattle
Genetics, Inc., Bothell, WA.
1274. Vitamin D Suppresses the Pathogenic Behavior of Primary
Th17 Cells from Patients with Early RA in Synovial Fibroblast
Activation. Jan Piet van Hamburg 3 , Patrick Asmawidjaja 3 , Anne-
Marie Mus 3 , Mieke Hazes 2 , Hans van Leeuwen 1 , Edgar Colin 2
and Erik Lubberts 4 , 1 Department of Internal Medicine, Erasmus
MC, University Medical Center Rotterdam, 2 Department
of Rheumatology, Erasmus MC, University Medical Center
Rotterdam, 3 Departments of Rheumatology and Immunology,
Erasmus MC, University Medical Center Rotterdam, 4 Erasmus
MC, Rotterdam, ZH, The Netherlands.
Large-Vessel Vasculitis and Behçet’s Disease I
1275. 18F-Fluorodeoxyglucose Positron Emission Tomography
Scanning (FDG-PET/CT) in Evaluation of Disease Activity
in Takaysu Arteritis. Øyvind Palm 3 , Birgir Gudbrandsson 2 ,
Torhild Garen 2 , Kjersti Johnsrud 1 and Jan Tore Gran 2 , 1 Section
for Nuclear Medicine, OUS, Rikshospitalet, 2 Section for
Rheumatology, OUS, Rikshospitalet, 3 Section for Rheumatology,
OUS, Rikshospitalet, Oslo, Norway.
1276. A Double-Blind Placebo Controlled Trial of Infliximab
in Patients with Corticosteroid-Dependent Polymyalgia
Rheumatica. Victor M. Martinez-Taboada 11 , Francisco Javier
López-Longo 10 , Rosario García de Vicuña 8 , Jordi Gratacos 5 ,
Georgina Espígol-Frigolé 2 , Julio Medina 6 , Javier Narváez 3 , Rosa
Roselló 7 , Luis Carreño 9 , Iñigo Rua-Figueroa 4 and María Cintia
Cid 1 , 1 Hospital Clinic, Barcelona, Spain, 2 Hospital Clinic, Spain,
3
Hospital de Bellvitge, Barcelona, Spain, 4 Hospital Doctor Negrín,
Spain, 5 Hospital Parc Taulí, Barcelona, Spain, 6 Hospital Río
Carrión, Palencia, Spain, 7 Hospital San Jorge de Huesca, Spain,
8
Hospital Universitario de la Princesa, Madrid, Spain, 9 Hospital
Universitario Gregorio Maranón, Madrid, Spain, 10 Hospital
Universitario Gregorio Maranón, Spain, 11 Hospital Universitario
Marqués de Valdecilla, Santander, Spain.
1277. Adverse Outcomes of Glucocorticoid Therapy among Patients
with Giant Cell Arteritis. Laura López Vives, Javier Narvaez,
Paula Estrada, Carmen Gómez Vaquero and Joan Miquel
Nolla, Department of Rheumatology, Hospital Universitario de
Bellvitge, Barcelona, Spain.
1278. Alemtuzumab (CAMPATH-1H) as Remission Induction Therapy
in Behcet’s Disease. Rona M. Smith 1 , Yok W. Chow 2 and David
R. W. Jayne 1 , 1 Addenbrooke’s Hospital, Cambridge, United
Kingdom, 2 Hospital Pantai Ayer Keroh Melaka, Malaysia.
1279. Ankylosing Spondylitis Associated with Takayasu Arteritis.
Süleyman Yildirim, Gülen Hatemi, Sebahattin Yurdakul, Izzet
Fresko and Huri Ozdogan, Istanbul University, Cerrahpasa
Medical School, Rheumatology.
2010 Program Book 227