B O O K - American College of Rheumatology
B O O K - American College of Rheumatology
B O O K - American College of Rheumatology
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ACR Poster Session A<br />
281. Innovative Treatment <strong>of</strong> Experimental Arthritis and Inhibition<br />
<strong>of</strong> Human Osteoclasts Differentiation by Dendrimers. Myriam<br />
Hayder 2 , Mary Poupot 1 , Jean-Pierre Majoral 4 , Cédric Olivier<br />
Turrin 4 , Anne-Marie Caminade 4 , Alain Cantagrel 3 , Jean-Jacques<br />
Fournié 1 , Rémy Poupot 1 and Jean-Luc Davignon 3 , 1 INSERM U563,<br />
CPTP, IFR150, Toulouse, France, 2 JE2510, IFR150, Paul Sabatier<br />
University, Toulouse, France, 3 JE2510, IFR150, Paul Sabatier<br />
University, University Hospital Purpan, Toulouse, France,<br />
4<br />
Laboratoire de Chimie de Coordination, CNRS, Toulouse,<br />
France.<br />
282. IRF-1 Reduces TNFα-Induced-IL-18 Bioactivity in Rheumatoid<br />
Arthritis Synovial Fibroblasts by Induction <strong>of</strong> IL-18BPa.<br />
Hubert Marotte 1 , Adam J. Pinney 2 , Tatiana Fedorora 2 , Nalin<br />
Lalwani 2 , Pei-Suen Tsou 2 , Bradley J. Rabquer 2 and Alisa E.<br />
Koch 3 , 1 University <strong>of</strong> Michigan Medical School, Ann Arbor,<br />
MI, 2 University <strong>of</strong> Michigan Medical School, 3 Veteran’s<br />
Administration and University <strong>of</strong> Michigan.<br />
283. Liposomal Targeting <strong>of</strong> Glucocorticoids to the Synovial Lining<br />
during Experimental Arthritis Inhibits M1 Macrophage<br />
Activation in Favour <strong>of</strong> M2 Differentiation. Wouter H<strong>of</strong>kens 2 ,<br />
Gert Storm 3 , Wim B. Van Den Berg 1 and Peter van Lent 2 ,<br />
1<br />
Radboud Univ Nijmegen Med Cntr, Nijmegen, The Netherlands,<br />
2<br />
Radboud University Nijmegen Medical Center, 3 Utrecht<br />
University.<br />
284. Nanoparticles <strong>of</strong> LDE: A Potential Delivery Route for MTX<br />
in Sinovial Tissue <strong>of</strong> Antigen-Induced Arthritis. Suzana B.<br />
V. Mello 2 , Eloisa D. O. Bonfá 3 , Claudete J. Valduga 1 , Adriana<br />
Bugaralli 1 , Elaine R. Tavarez 1 and Raul Maranhão 1 , 1 Heart<br />
Institute (InCor), Faculdade de Medicina da Uiversidade de<br />
São Paulo, 2 Reumatology Division, Faculdade de Medicina da<br />
Unversidade de São Paulo, São Paulo, Brazil, 3 <strong>Rheumatology</strong><br />
Division, Faculdade de Medicina da Universidade de São Paulo.<br />
285. Novel Small Molecule Aminopyridizines Inhibit Rat<br />
Collagen-Induced Arthritis and Suppress Proinflammatory<br />
Cytokine Pathways. Soo-In Choi 2 , Lori D. Klaman 3 , Bruce<br />
Connop 3 , Aleksandra Pastrak 3 and Ernest Brahn 1 , 1 Division <strong>of</strong><br />
<strong>Rheumatology</strong>, UCLA School <strong>of</strong> Medicine, Los Angeles, CA,<br />
2<br />
Division <strong>of</strong> <strong>Rheumatology</strong>, UCLA School <strong>of</strong> Medicine and<br />
VA Greater Los Angeles Healthcare System, Los Angeles, CA,<br />
3<br />
Transition Therapeutics.<br />
286. PCI-45292, a Novel Btk Inhibitor with Optimized<br />
Pharmaceutical Properties, Demonstrates Potent Activities in<br />
Mouse Models <strong>of</strong> Arthritis. Betty Y. Chang 2 , Patricia Thiemann 1 ,<br />
Nadia Moore 3 , Michelle Francesco 3 , Min Mei Huang 3 , Chitra<br />
Mani 3 , Purvi Jejurkar 3 , Danielle Tonev 3 , Wei Chen 3 , Joseph J.<br />
Buggy 3 and David J. Loury 3 , 1 Pharmacyclics, 2 Pharmacyclics,<br />
Research, Sunnyvale, CA, 3 Pharmacylics.<br />
287. Recognition <strong>of</strong> IL-23 Dependent and Independent Stages<br />
during Autoimmune Collagen-Induced Arthritis. Ferry<br />
Cornelissen 2 , Patrick Asmawidjaja 2 , Anne-Marie Mus 2 , Odilia<br />
Corneth 2 , Kristine Kikly 1 and Erik Lubberts 2 , 1 Eli Lilly, 2 Erasmus<br />
MC, University Medical Center.<br />
288. RO2492, a Phosphoinositide-3-Kinase d Inhibitor, Shows<br />
Inhibitory Effects in a Variety <strong>of</strong> Human Cell Types and<br />
Suppresses Collagen-Induced Arthritis in Mice. Cheng Liao 4 ,<br />
Pei-Yuan Hsu 4 , Shu Jin 2 , Vaishali Patel 2 , Mattew C. Lucas 3 , Yong<br />
Nam Kim 3 , Joe Dalpoto 3 , Karim Dabbagh 3 , Emma Masteller 3 ,<br />
Brian R. Wong 1 , Satwant K. Narula 2 and Julie A. Demartino 3 ,<br />
1<br />
H<strong>of</strong>fma-La Roche Inc., San Francisco, CA, 2 H<strong>of</strong>fma-La Roche<br />
Inc., Nutley, NJ, 3 H<strong>of</strong>fma-La Roche Inc., 4 H<strong>of</strong>fmann-La Roche Inc.,<br />
Nutley, NJ.<br />
289. Selective Switch Pocket Kinase Inhibitors Suppress<br />
Autoimmune Inflammatory Models <strong>of</strong> Rheumatoid Arthritis.<br />
Soo-In Choi 3 , Scott C. Wise 1 , Daniel L. Flynn 1 , Zejin Zhu 3 and<br />
Ernest Brahn 2 , 1 Deciphera Pharmaceuticals, 2 Division <strong>of</strong><br />
<strong>Rheumatology</strong>, UCLA School <strong>of</strong> Medicine, Los Angeles, CA,<br />
3<br />
Division <strong>of</strong> <strong>Rheumatology</strong>, UCLA School <strong>of</strong> Medicine and VA<br />
Greater Los Angeles Healthcare System, Los Angeles, CA.<br />
290. The Effects <strong>of</strong> Low Dose Etanercept on Disease Control<br />
and Radiographic Progression in Moderate to Severe<br />
Rheumatoid Arthritis. Bernd Raffeiner 1 , Costantino Botsios 2 ,<br />
Paolo Sfriso 2 , Francesca Ometto 2 , Livio Bernardi 2 , Silvano<br />
Todesco 2 and Leonardo Punzi 2 , 1 University Hospital <strong>of</strong> Padova -<br />
<strong>Rheumatology</strong> Unit, Padova, Italy, 2 University Hospital <strong>of</strong> Padova<br />
- <strong>Rheumatology</strong> Unit (Italy).<br />
291. TNF Inhibitors Induce the Fibrosis in Deep Lining Layers <strong>of</strong> the<br />
Synovium with Degeneration <strong>of</strong> Synoviocytes in Rheumatoid<br />
Arthritis. Shunsei Hirohata 1 , Tetsuya Tomita 2 , Hideki Yoshikawa 3<br />
and Masahisa Kyogoku 4 , 1 Kitasato Univ School <strong>of</strong> Med,<br />
Kanagawa, Japan, 2 Osaka Univ Med School, Suita Osaka, Japan,<br />
3<br />
Osaka Univ Med School, 4 Tohoku Univ School <strong>of</strong> Med.<br />
292. TNFα-Induced Adipose-Related Protein (TIARP) Regulates<br />
Autoimmune Arthritis Via the Suppression <strong>of</strong> IL-6. Asuka<br />
Inoue 1 , Isao Matsumoto 2 , Yoko Tanaka-Watanabe 2 , Kayo<br />
Yamamoto 2 , Naoto Umeda 2 , Yuki Tanaka 2 and Takayuki Sumida 3 ,<br />
1<br />
Division <strong>of</strong> Clinical Immunology, Doctoral Program in Clinical<br />
Sciences, Graduate School <strong>of</strong> Comprehensive Human Sciences,<br />
University <strong>of</strong> Tsukuba/ JSPS Research Fellow, Tsukuba City,<br />
Ibaraki, Japan, 2 University <strong>of</strong> Tsukuba, 3 University <strong>of</strong> Tsukuba/<br />
Inst Clin Med, Tsukuba City, Japan.<br />
293. Tyrosin Kinases Are Essential Mediators in the Development<br />
<strong>of</strong> Antigen Induced Arthritis Regulating Formation <strong>of</strong><br />
Dendritic Cells and Antigen Presentation. Mats I. Dehlin 1 ,<br />
S<strong>of</strong>ia Andersson 2 , Malin Erlandsson 2 and Maria Bokarewa 2 ,<br />
1<br />
Department <strong>of</strong> <strong>Rheumatology</strong> and Inflammation Research,<br />
Sahlgrenska University Hospital, University <strong>of</strong> Göteborg,<br />
Gothenburg, Sweden, 2 Department <strong>of</strong> <strong>Rheumatology</strong> and<br />
Inflammation Research, Sahlgrenska University Hospital,<br />
University <strong>of</strong> Göteborg, Sweden.<br />
Rheumatoid Arthritis - Clinical Aspects: Drug Studies, Drug<br />
Safety, Disease Activity and Remission, Infections I<br />
294. A Decrease in Neutrophil Counts Following a Single Infusion<br />
<strong>of</strong> Tocilizumab Is Predictive <strong>of</strong> Low Disease Activity and<br />
Remission after 24 Weeks. Jasemine Saech 2 , Kathrin Kuhr 1 ,<br />
Matthias Laudes 1 , Olaf Schultz 1 , Thomas Rath 1 , Tobias Roehrs 1<br />
and Andrea Rubbert-Roth 1 , 1 University Clinic Cologne,<br />
2<br />
University Clinic <strong>of</strong> Cologne, Cologne.<br />
295. A Simplified Disease Activity Score (DAS): Validation in the<br />
BeSt Trial. Rosanne Koevoets 6 , Yvonne Goekoop-Ruyterman 2 ,<br />
Desiree M. Van Der Heijde 5 , K. H. Han 7 , H. K. Ronday 1 , T. W. J.<br />
Huizinga 6 , P. J. S. M Kerstens 3 , B. A. C. Dijkmans 8 and Cornelia<br />
F. Allaart 4 , 1 Haga Hospital, Den Hague, 2 Haga Hospital, Den<br />
Hague, The Netherlands, 3 JBI, Amsterdam, 4 Leiden Univ Med<br />
Ctr, Leiden, The Netherlands, 5 Leiden University Medical Center,<br />
Meerssen, The Netherlands, 6 Leiden University Medical Centre,<br />
Leiden, The Netherlands, 7 Maasstad Hospital, Rotterdam, 8 VU<br />
Medical Centre, Amsterdam, The Netherlands.<br />
296. Aiming To Reach Remission – Is It Worthwhile? Helga Radner 3 ,<br />
Josef S. Smolen 1 and Daniel Aletaha 2 , 1 Krankenhaus Lainz,<br />
Vienna, Austria, 2 Medical University <strong>of</strong> Vienna, Vienna, Austria,<br />
3<br />
Medical University Vienna, Vienna, Austria.<br />
166<br />
2010 Program Book