B O O K - American College of Rheumatology

ACR/ARHP Poster Session C
1479. Endogenous Joint Repair after Damage in the Red-Spotted
Newt. Matthias Geyer 1 , Thilo Borchardt 2 , Carina Schreiyaeck 1 ,
Ulf Müller-Ladner 1 and Robert Dinser 1 , 1 Department of
Rheumatology, Justus Liebig University Giessen, Kerckhoff-
Klinik, Bad Nauheim, 2 Max Planck Institute for Heart and Lung
Research, Bad Nauheim.
1480. Experimental Osteoarthritis in Rats Is Attenuated by Treatment
with a Selective Inhibitor of Sphingosine Kinase 2. Leo R.
Fitzpatrick 3 , Cecelia Green 1 , Lynn W. Maines 1 and Charles
D. Smith 2 , 1 Apogee Biotechnology Corporation, 2 Apogee
Biotechnology Corporation and Medical University of South
Carolina, 3 Penn State College of Medicine, Hummelstown, PA.
1481. Expression of MMP-13 and ADAMTS-5 Is Mediated Via Nuclear
Orphan Receptor NR4A3 Signalling in Human Chondrocytes.
Martin H. Stradner 2 , Hannes Angerer 3 , Daniela Krusch 1 ,
Florentine C. Fürst 3 , Marie-Luise Kremser 3 , Daniela Setznagl 3 and
Winfried B. Graninger 3 , 1 Karl-Franzens University Graz, 2 Medical
University Graz, Graz, Austria, 3 Medical University Graz.
1482. Histamine Contributes to Inflammatory Joint Disease by
Regulating the Expression of RANKL and OPG through
Altered NR4A Activity in Human Chondrocyte Cells. Viviana
Marzaioli 2 , Jason P. McMorrow 2 , Alice McEvoy 1 and Evelyn P.
Murphy 2 , 1 Dublin Institute of Technology, Kevin Street, Dublin,
Ireland, 2 UCD Veterinary Sciences Centre and Conway Insitute
for Biomolecular and Biomedical Research, Human Amniotic
Membrane as Scaffold for Human Articular Cartilage Repair.
Emma Muiños-López 4 , Silvia M. Díaz-Prado 3 , Tamara Hermida-
Gómez 2 , Esther Rendal-Vázquez 1 , Isaac Fuentes-Boquete 3 ,
María C. Arufe-Gonda 3 , Francisco J. De Toro 3 and Francisco J.
Blanco 2 , 1 Cryobiology Unit. Complejo Hosp. Univ. A Coruña, A
Coruña, Spain, 2 Osteoarticular and Aging Res. Lab. CIBER-BBN,
Rheumatology Div, INIBIC-Complejo Hosp, Univ. A Coruña, A
Coruña, SPAIN, 3 Osteoarticular and Aging Res. Lab. CIBER-BBN,
Rheumatology Div. INIBIC-Complejo Hosp, Univ. A Coruña, A
Coruña, SPAIN. INIBIC-University of A Coruña, A Coruña, SPAIN,
4
Osteoarticular and Aging Res. Lab. CIBER-BBN. Rheumatology
Div. INIBIC-Complejo Hosp. Univ. A Coruña, Coruña, Spain.
1484. Increased Expression of Arthritic Marker Genes in the Cartilage
of SirT1 Null Mice. Odile H. Gabay 2 , Eun Jin Lee 2 , Richard
Booth 2 , Viktoria Gagarina 2 , Mona Dvir-Ginzberg 1 and David J.
Hall 2 , 1 Hebrew University, Jerusalem, Israel, 2 NIH, Bethesda, MD.
1485. Increasing Osteoclastic Bone Loss Inspite of Fewer Osteoclast
Precursors during Chronic Autoimmune SKG-Arthrtitis
Evaluated by 3D Stereological Estimators. Kresten K. Keller 3 ,
Kristian Stengaard-Pedersen 2 , Frederik Dagnæs-Hansen 5 , Jens
R. Nyengaard 6 , Shimon Sakaguchi 1 and Ellen-Margrethe Hauge 4 ,
1
Department of Experimental Pathology, Institute for Frontier
Medical Science, Kyoto University, 2 Dept. of Rheumatology,
Aarhus University Hospital, Aarhus, Denmark, 3 Dept. of
Rheumatology, Aarhus University Hospital, Århus, Denmark,
4
Dept. of Rheumatology, Aarhus University Hospital, Denmark,
5
Institut of Medical Microbiology and Immunology, Aarhus
University, Denmark, 6 Stereology and Electron Microscopy
Research Laboratory, Aarhus University, Denmark.
1486. Influence of NPP1 on Osteoarthritis (OA)-Associated Cartilage
Calcification. Jessica Bertrand 3 , Martin Fürst 5 , Wolfgang Rüther 1 ,
Frank Rutsch 2 , Yvonne Nitschke 2 and Thomas Pap 4 , 1 Centre for
Orthopaedics and Trauma Surgery, 2 Department of Pedriatrics,
3
Insitute for Experimental Musculoskeletal Medicine, Münster,
Germany, 4 Insitute for Experimental Musculoskeletal Medicine,
5
MedBaltic.
1487. Inhibitory кBα Is a Direct Bone Morphogenetic Protein Target
Gene and an Essential Mediator of Anti-Catabolic Effects of
BMPs. Olexandr Korchynskyi 3 , Paul-Peter Tak 3 , Alisa E. Koch 2 ,
Peter ten Dijke 1 and Dhavalkumar D. Patel 4 , 1 Department
of Molecular Cell Biology, Leiden University Medical Cente,
Leiden, The Netherlands, 2 Department of Veteran’s Affairs
and the University of Michigan, Ann Arbor, MI, 3 Division of
Clinical Immunology & Rheumatology, Academic Medical
Center, University of Amsterdam, Amsterdam, The Netherlands,
4
Thurston Arthritis Research Center, University of North Carolina
at Chapel Hill, Chapel Hill, NC.
1488. Interleukin-10 Regulates Bone Metabolism by Suppressing
Osteoclastogenesis In Vivo. Seungwoo Han 4 , Younkwan
Jung 3 , Eunsoo Kim 2 and Gunwoo Kim 1 , 1 CIHR Group in Skeletal
Development and Remodeling, Department of Physiology and
Pharmacology, University of Western Ontario, London, ON,
Canada, 2 Dongsan Medical Center, Keimyung University, Daegu,
Korea, Republic of, 3 Laboratory for Arthritis and Bone Biology,
Fatima Research Institute, Korea, Republic of, 4 Laboratory
for Arthritis and Bone Biology, Fatima Research Institute,
Department of Internal Medicine, Daegu Fatima Hospital,
Daegu, Korea, Republic of.
1489. Interleukin-1-Induced Cyclooxygenase-2 and Inducible Nitric
Oxide Synthase Expression in Human OA Chondrocytes Is
Associated with Histone H3K4 Methylation. Fatima Ezzahra
El-Mansouri 3 , Nadir Chabane 3 , Nadia Zayed 3 , Johanne Martel-
Pelletier 2 , Jean-Pierre Pelletier 1 and Hassan Fahmi 3 , 1 CHUM
- Notre-Dame Hospital, Montreal, QC, Canada, 2 CR-CHUM,
Notre-Dame Hospital, Montreal, QC, Canada, 3 Osteoarthritis
Research Unit, University of Montreal Hospital Research Centre
(CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada.
1490. miR-7 and miR-130b Are Differentially Regulated during
Mesenchymal Stem Cell Commitment. Glyn Palmer 4 , Laura S.
Danielson 2 , Mukundan Attur 3 , Steven B. Abramson 1 and Eva
Hernando 2 , 1 Hospital for Joint Dis/NYU, New York, NY, 2 NYU-
Department of Pathology, 3 NYU-Hospital for Joint Diseases,
4
NYU-Hospital for Joint Diseases, New York, NY.
1491. MMP-3 and DKK-1 Levels in Juvenile Idiopathic Arthritis.
Matthew L. Stoll 2 , Michelle L. Christadoss 2 , Marilynn G. Punaro 2
and Nancy J. Olsen 1 , 1 Penn State Hershey Medical Center,
Hershey, PA, 2 UT Southwestern Med Ctr, Dallas, TX.
1492. Modeling Osteoclast Precursor Master Fusogens and
Mononuclear OCP Donors with Raw Cell Line Clones. Yawen
Ju, Masahiko Takahata, Kofi Mensah, Grace Chiu, Christopher
T. Ritchlin, Lianping Xing and Edward M. Schwarz, University of
Rochester.
1493. Multi-Targeted Kinase Inhibitor PKC412 Diminishes
Osteoclastogenesis and Counteracts Osteoclast Mediated
Bone Resorption In Vitro. Despoina Sykoutri 1 , Silvia Hayer 3 ,
Josef S. Smolen 4 and Kurt Redlich 2 , 1 Division of Rheumatology,
Department of Internal Medicine III, Medical University of
Vienna, Vienna, Austria, 2 Division of Rheumatology, Department
of Internal Medicine III, Medical University of Vienna, Vienna,
Austria, 3 Division of Rheumatology, Department of Internal
Medicine III, Medical University of Vienna, 4 Krankenhaus Lainz,
Vienna, Austria.
1494. Potential Role of the LKB1-AMPK and CaMKKb-AMPK
Pathways in Controlling the Progression of OA. Robert
Terkeltaub 3 , Bing Yang 4 , Martin K. Lotz 1 and Ru L. Bryan 2 ,
1
Scripps Rsch Inst, La Jolla, CA, 2 UCSD/VAMC, San Diego, CA, 3 VA
Medical Ctr, San Diego, CA, 4 VA Medical Ctr.
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2010 Program Book