B O O K - American College of Rheumatology

ACR Poster Session A
Systemic Lupus Erythematosus - Animal Models
422. Altered microRNA Expression in the Murine Tri-Congenic
B6.Sle123 Model. Barry Garchow 1 , Yiu Tak Leung 3 , Roberto
Caricchio 2 and Marianthi Kiriakidou 1 , 1 Department of Medicine,
University of Pennsylvania School of Medicine, Philadelphia,
PA, 2 Temple Univ Med Office Bldg, Philadelphia, PA, 3 Thomas
Jefferson University Hospital, Philadelphia, PA.
423. Amelioration of Lupus Nephritis by a Macromolecular Prodrug
of Dexamethasone in NZB/W F1 Mice. Fang Yuan 2 , Richard K.
Nelson 2 , Xin-ming Liu 2 , Karen A. Gould 2 and Dong Wang 1 , 1 Univ
Nebraska Med Ctr, Omaha, NE, 2 University of Nebraska Medical
Center.
424. An Intrinsic B Cell Defect That Affects Toll-Like Receptor
Signaling Supports Autoimmunity in New Zealand Black
Chromosome 13 Congenic Mice. Christina Loh 2 , Evelyn Pau 3 ,
Nan-Hua Chang 1 and Joan E. Wither 2 , 1 University Health
Network, 2 University of Toronto, Toronto, ON, Canada,
3
University of Toronto.
425. Breach of B Cell Tolerance in New Zealand Black Chromosome
1 Congenic Mice. Nan-Hua Chang 1 , Evelyn Pau 3 , Christina Loh 3
and Joan E. Wither 2 , 1 Toronto Western Research Institute,
Toronto, ON, Canada, 2 University Health Network, Toronto, ON,
Canada, 3 University of Toronto.
426. Dysfunction of Hematopoietic Stem Cells in Lupus Mice. Haitao
Niu 2 , Luokun Xie 3 , Laurence Marguerite Morel 4 , Betty Diamond 1
and Yong-rui Zou 3 , 1 Feinstein Institute for Medical Research,
Manhasset, NY, 2 The Feinstein Institute for Medical Research,
Manhasset, NY, 3 The Feinstein Institute for Medical Research,
4
University of Florida.
427. Engraftment of PBMC from SLEand ACL Donors into BALB-
Rag2 -/- IL2Rgc - KO Mice: A Promising Model for Studying
SLE. Danieli Andrade 1 , Milena Vukelic 2 , Patricia B. Redecha 1 ,
Xiaoping Qing 1 , Giorgio Perino 3 , Jane E. Salmon 2 and Gloria C.
Koo 4 , 1 Hospital for Special Surgery, NY, NY, 2 Hospital for Special
Surgery, New York, NY, 3 Hospital for Special Surgery, NY, NY,
4
Hospital for Special Surgery, New York, NY.
428. Enhancement of IL-17 and Interferon-gamma Inflammatory
Pathways in IRF9-/- MRL/lpr Mice with Disrupted Type I
Interferon Signaling. Alvina D. Chu 2 , Nicole H. Kattah 3 , Michael
T. Wong 3 , Catherine Tadina 3 and Paul J. Utz 1 , 1 Stanford Univ Schl
of Med, Stanford, CA, 2 Stanford University School of Medicine,
Palo Alto, CA, 3 Stanford University School of Medicine.
429. Epistatic Interactions between Lupus Susceptibility Loci on
New Zealand Black Chromosomes 1 and 13 Lead to Marked
Expansion of Dendritic Cell Populations but Have Little Effect
on Autoimmunity. Yui Ho Cheung 2 , Evelyn Pau 2 and Joan E.
Wither 1 , 1 University Health Network, Toronto, ON, Canada,
2
University of Toronto, Toronto, ON, Canada.
430. Hypercholesterolaemia and Autoimmunity Interact in a
Mouse Model of Systemic Lupus Erythematosus To Enhance
Both Atherosclerosis and Renal Inflammation, but by Distinct
Mechanisms. Myles J. Lewis 2 , Talat H. Malik 2 , Liliane M. Fossati-
Jimack 2 , Daniele Carassiti 2 , Terence H. Cook 2 , Dorian O. Haskard 1
and Marina Botto 1 , 1 Imperial College, London, United Kingdom,
2
Imperial College.
431. IL-17 Promotes Autoimmunity in Pristane-Induced Lupus.
Elaine V. Lourenco, Chunlin Cai, Bevra H. Hahn and Antonio La
Cava, UCLA.
432. IL-21 Promotes Autoimmune Features in Chronic Graft Versus
Host Disease by Enhancing T Follicular Helper Development
and B Cell Response. Vinh Nguyen 3 , Irina G. Luzina 1 , Qing Chen 1 ,
Horea Rus 1 and Violeta Rus 2 , 1 Baltimore, MD, 2 Univ of Maryland
Schl of Med, Baltimore, MD, 3 University of Maryland School of
Medicine, Baltimore, MD.
433. Interferon Regulatory Factor-5 (IRF-5) Is Critical for the
Development of Lupus in MRL/lpr Mice. Yoshifumi Tada 3 , Seiji
Kondo 4 , Shigehisa Aoki 2 , Syuichi Koarada 3 , Hisako Inoue 3 , Rie
Suematsu 3 , Akihide Ohta 1 and Kohei Nagasawa 3 , 1 Department
of Clinical Nursing, Saga University, Saga, Japan, 2 Department
of Pathology, Saga University, Saga, Japan, 3 Department of
Rheumatology, Saga University, Saga, Japan, 4 National Hospital
Organization Kyushu Medical Center, Fukuoka, Japan.
434. Interferonα Causes SLE by Expanding CD3+ CD4- CD8- Double
Negative T Cell (DN T Cell). Chieri Akiyama 1 , Eriko Honda 1 ,
Akira Hashiramoto 2 , Dean W. Felsher 3 and Shunichi Shiozawa 2 ,
1
Department of Biophysics, Graduate School of Health
Science, Kobe University, Kobe, Hyogo, Japan, 2 Department of
Biophysics, Graduate School of Health Science, Kobe University/
Department of Medicine, Graduate School of Medicine, Kobe
University/The Center for Rheumatic Disease, Kobe University
Hospital, Kobe, Japan, 3 Stanford University, School of Medicine,
Division of Oncology, Department of Medicine and Pathology,
Stanford, CA.
435. IRF4-Deficient Lupus-Prone MRL/lpr Mice Lack Serum Ig/
Auto-Abs and Th17 Cells but Develop Non-Immune Complex-
Mediated Diffuse Proliferative Glomerulonephritis and
Dermatitis/Ear Necrosis. Hideharu Sekine 4 , Takeshi Machida 1 ,
Eiji Suzuki 3 , Efrain Martinez Avila 3 , Phil Ruiz 5 , Christopher M.
Reilly 6 and Gary S. Gilkeson 2 , 1 Fukushima Medical University,
Fukushima, Japan, 2 Med Univ of South Carolina, Charleston, SC,
3
Medical University of South Carolina, Charleston, SC, 4 Medical
University of South Carolina/Fukushima Medical University,
Charleston, SC, 5 University of Miami, Miami, FL, 6 Virginia Tech,
VA.
436. Long-Term Anti-CD20 Treatment Reduces Antibody-Secreting
Ells in NZB/W Lupus Mouse. Wensheng Wang 2 , Terasa Owen 2 ,
Travis Ichikawa 2 and Jennifer H. Anolik 1 , 1 University of Rochester,
Rochester, NY, 2 University of Rochester Medical Center,
Rochester, NY.
437. Mitochondrial Dysfunction in T Cells Precede Disease
Development in Lupus-Prone Mice. Tiffany Telarico 4 , David R.
Fernandez 4 , Ann F. Hofbauer 2 , Gary S. Gilkeson 1 , Jim C. Oates 3
and Andras Perl 5 , 1 Med Univ of South Carolina, Charleston, SC,
2
Medical University of South Carolina, 3 MUSC, Charleston, SC,
4
SUNY, 5 Upstate Medical Univ, Syracuse, NY.
438. Molecular Mechanisms of Lupus Dyslipidemia in Mice.
Nilamadhab Mishra 1 , Kailin Yan 3 and Qiang Cao 2 , 1 Wake Forest
Univ Health Scienc, Winston-Salem, NC, 2 Wake Forest University
Health Sciences, 3 Wake Forest University Unv Health Sciences.
439. Nuclear Modifications during Apoptosis Are Required To
Maintain Tolerance to Nuclear Antigens. Neelakshi R. Jog 1 ,
Eline Luning-Prak 2 and Roberto Caricchio 1 , 1 Temple University,
2
University of Pennsylvania.
440. PARP-1 Deficiency Leads to More Severe Glomerulonephritis
and Increased Mortality in an Inducible Mouse Model of SLE.
Maximilian F. Koenig 1 , Serena M. Bagnasco 1 , Janelle Montagne 1 ,
Antony Rosen 2 and Thomas Grader-Beck 2 , 1 Johns Hopkins School
of Medicine, 2 Johns Hopkins School of Medicine, Baltimore, MD.
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2010 Program Book