B O O K - American College of Rheumatology

ACR Poster Session A
599. Validation of 6 Minute Walking Distance in Patients with
Pulmonary Arterial Hypertension Associated with Systemic
Sclerosis. Dörte Huscher 11 , Nicholas Roubinis 17 , Jerome
Avouac 18 , Frank Behrens 10 , Christopher P. Denton 1 , Daniel E.
Furst 8 , Ivan Foeldvari 14 , Marc Humbert 19 , Otylia Kowal-Bielecka 4 ,
Marco Matucci-Cerinic 3 , Peter Nash 6 , Christian F. Opitz 2 ,
David Pittrow 13 , Lewis J. Rubin 7 , James R. Seibold 9 , Marius M.
Hoeper 12 , Mark F. Morris 15 , Simon A. Teal 16 and Oliver Distler 5 ,
1
Centre for Rheumatology, Royal Free Campus, University
College Medical School, London, United Kingdom, 2 Department
of Internal Medicine, DRK-Kliniken Berlin Köpenick, Berlin,
Germany, 3 Department of Medicine, Division of Rheumatology,
Denothe Center, University of Florence, Italy, 4 Department of
Rheumatology and Internal Medicine, Medical University of
Bialystok, Poland, 5 Department of Rheumatology, University
Hospital Zurich, Zurich, Switzerland, 6 Dept. of Medicine,
University of Queensland, Queensland, Australia, 7 Division
of Pulmonary and Critical Care Medicine, University of
California, San Diego School of Medicine, La Jolla, 8 Division of
Rheumatology, Department of Medicine, David Geffen School
at UCLA, Los Angeles, CA, 9 Division of Rheumatology, University
of Connecticut, Farmington, CT, 10 Division of Rheumatology/
ZAFES, J.W. Goethe University, Frankfurt, Germany, 11 German
Rheumatism Research Centre, Berlin, Germany, 12 Hannover
Medical School, Department of Pneumology, Hannover,
Germany, 13 Institute for Clinical Pharmacology, Medical
Faculty, Technical University, Dresden, Germany, 14 Pediatric
Rheumatology Clinic, General Hospital Eilbek, Germany, 15 Pfizer
Ltd, Sandwich, UK, 16 Pfizer Ltd, Tadworth, UK, 17 Quanticate Ltd,
Hitchin, UK, 18 Rheumatology A Department, RDU, Paris, France,
19
Service de Pneumologie et Reanimation Respiratoire, Centre
des Maladies Vasculaires Pulmonaires, Hopital Antoine-Beclere,
Université Paris-Sud, Clamart, France.
Systemic Sclerosis, Fibrosing Syndromes and Raynaud’s-Pathogenesis
and Animal Models I
600. Adenosine A 2 A Receptor Occupancy Promotes Dermal Fibrosis
by Modulating FLI 1 and CTGF Expression. Hailing Liu 3 , Edwin
Chan 2 , Patricia Fernández 2 and Bruce N. Cronstein 1 , 1 New York
Univ Med Ctr, New York, NY, 2 NYU School of Medicine, 3 NYU
School of Medicine, New York, NY.
601. Adipocyte-Targeted Wnt Activation Results in Spontaneous
Dermal Fibrosis and Subcutaneous Lipoatrophy. Jun Wei 3 ,
Denisa S. Melichian 2 , Kazuhiro Kumora 2 , Ormond Macdougald 4
and John Varga 1 , 1 Northwestern Univ Feinberg School, Chicago,
IL, 2 Northwestern University Feinberg School of Medicine,
3
Northwestern University Feinberg School of Medicine, Chicago,
IL, 4 University of Michigan.
602. Cadherin 11 Promotes Pulmonary Fibrosis through Production
of TGF β and the Regulation of Epithelial to Mesenchymal
Transition. Daniel J. Schneider 1 , Minghua Wu 4 , Thuy T. Le 2 ,
Seo-Hee Cho 3 , Michael B. Brenner 5 , Michael R. Blackburn 2
and Sandeep K. Agarwal 4 , 1 Department of Biochemistry and
Molecular Biology, University of Texas Health Science Center,
Houston, TX, 2 Department of Biochemistry and Molecular
Biology, University of Texas Health Science Center, 3 Department
of Pediatrics, Pediatric Research Center, University of Texas
Health Science Center, 4 Division of Rheumatology and Clinical
Immunogenetics, The University of Texas-Houston Medical
School, Houston, TX, 5 Division of Rheumatology, Immunology
and Allergy, Brigham and Women’s Hospital and Harvard
Medical School.
603. Cadherin-11 in Systemic Sclerosis and Its Role in Dermal
Fibrosis. Minghua Wu 3 , Michael B. Brenner 1 , Maureen D.
Mayes 4 , Frank C. Arnett 5 , Filemon K. Tan 6 and Sandeep K.
Agarwal 2 , 1 Brigham & Womens Hospital, Boston, MA, 2 Division
of Rheumatology and Clinical Immunogenetics, University of
Texas Health Science Center at Houston, Houston, TX, 3 Division
of Rheumatology and Clinical Immunogenetics, University of
Texas Health Science Center at Houston (UTHSC-H), Houston,
TX, 4 University of Texas-Houston, Houston, TX, 5 UT Medical
School, Houston, TX, 6 UT-Houston Med School, Houston, TX.
604. Dabigatran Etexilate, an Oral Direct Thrombin Inhibitor,
Represses Fibrotic Changes in a Murine Model of Pulmonary
Fibrosis. Galina Bogatkevich 3 , Anna Ludwicka-Bradley 3 , Paul J.
Nietert 4 , Joanne van Ryn 1 and Richard M. Silver 2 , 1 Boehringer
Ingelheim, 2 Medical University of South Carolina, Charleston,
SC, 3 Medical University of South Carolina, Charleston, SC,
4
Medical University of South Carolina.
605. Endothelial Dysfunction and Abnormal Collagen V Deposition
in Pulmonary Vasculature of Experimental Systemic Sclerosis
Model. Roberta G. Marangoni 2 , Edwin R. Parra 1 , Ana Paula P.
Velosa 3 , Walcy R. Teodoro 3 , Vera L. Capelozzi 1 and Natalino H.
Yoshinari 3 , 1 Pathology Department, Faculdade de Medicina da
Universidade de São Paulo, 2 Rheumatology Division, Faculdade
de Medicina da Universidade de São Paulo, São Paulo, SP,
Brazil, 3 Rheumatology Division, Faculdade de Medicina da
Universidade de São Paulo.
606. Genetic Deletion or Pharmacologic Antagonism of LPA1
Ameliorates Dermal Fibrosis in a Mouse Model of Systemic
Sclerosis. Flavia V. Castelino 3 , Jon Seiders 1 , Gretchen Bain 1 ,
Chris King 1 , James Swaney 1 , Dan Lorrain 1 , Jerold Chun 5 , Andrew
D. Luster 2 and Andrew M. Tager 4 , 1 Amira Pharmaceuticals,
2
Massachusetts General Hospital, Charlestown, MA,
3
Massachusetts General Hospital, Boston, MA, 4 Massuchusetts
General Hospital, 5 Scripps Research Institute.
607. Inactivation of the Transcription Factor STAT4 Prevents
Inflammation-Driven Fibrosis in Systemic Sclerosis Animal
Models. Jerome Avouac 3 , Barbara G. Fürnrohr 2 , Michal Tomcik 4 ,
Katrin Palumbo 2 , Pawel Zerr 2 , Angelika Horn 2 , Clara Dees 2 ,
Alfiya Akhmetshina 2 , Christian Beyer 2 , Oliver Distler 1 , Georg
Schett 5 , Yannick Allanore 6 and Jorg H. W. Distler 7 , 1 Center of
Experimental Rheumatology and Zurich Center of Integrative
Human Physiology, University Hospital Zurich, Zurich,
Switzerland, 2 Department of Internal Medicine III and Institute
for Clinical Immunology, University of Erlangen-Nuremberg,
Erlangen, Germany, 3 Department of Internal Medicine III
and Institute for Clinical Immunology, University of Erlangen-
Nuremberg, Erlangen, Germany, Paris Descartes University,
Rheumatology A Department, Cochin Hospital, and INSERM
U781, Necker Hospital, Paris, Fr, 4 Department of Internal
Medicine III, University of Erlangen-Nuremberg, Erlangen,
Germany and Institute of Rheumatology and Connective
Tissue Research Laboratory, Department of Rheumatology of
the First Faculty of Medicine, Charles University i, 5 Friedrich
Alexander Univ, Erlangen, Germany, 6 Paris Descartes University,
Rheumatology A Department, Cochin Hospital, and INSERM
U781, Necker Hospital, Paris, France, 7 University of Erlangen,
Erlangen, Germany.
608. Induction of Peripheral Tissue Ischemia and Anti-Endothelial
Antibodies after B Cell Adoptive Transfer from RNP-Immunized
Mice. YunJuan Zang 3 , Irina Fernandez 3 , Maite Chavez 3 , Laisel
Martinez 1 and Eric L. Greidinger 2 , 1 Miami VA Medical Center,
2
Miami VA Medical Center and University of Miami Miller School
of Medicine, Miami, FL, 3 University of Miami Miller School of
Medicine.
2010 Program Book 189