B O O K - American College of Rheumatology

monday
2:45 pm
653. Specific Subgroup of New-Onset Systemic Juvenile
Idiopathic Arthritis without Overt Macrophage Activation
Syndrome Shares Similar Gene Expression Signature
with a Distinct Subset of Familial Hemophagocytic
Lymphohistiocytosis.
Keith A. Sikora, Ndate Fall, Michael G. Barnes, Janos Sumegi,
Alexandra H. Filipovich and Alexei A. Grom, Cincinnati Children’s
Hospital Medical Center, Cincinnati, OH
3:00 pm
654. A Genome-Wide Association Study for Juvenile Idiopathic
Arthritis Identifies Chromosome Region 3q13 near the T Cell
Receptor Co-Stimulatory Molecule CD80.
Susan D. Thompson 1 , Miranda Marion 10 , Marc Sudman 2 , Paula
S. Ramos 10 , Wendy Thomson 8 , Anne Hinks 8 , J. Peter Haas 7 ,
Sampath Prahalad 4 , John F. Bohnsack 9 , Carol Wise 6 , Marilynn G.
Punaro 5 , Carlos D. Rose 3 , Mary Ryan 2 , Monica Tsoras 2 , Michael
Wagner 2 , Mehdi Keddache 2 , Timothy Howard 10 , Carl Langefeld 10
and David N. Glass 1 , 1 Childrens Hospital Med Ctr, Cincinnati, OH,
2
Cincinnati Children’s Hospital Medical Center, 3 duPont Hospital
for Children, Wilmington, DE, 4 Emory Children’s Center, Atlanta,
GA, 5 Texas Scottish Rite Hospital for Children, Dallas, TX, 6 Texas
Scottish Rite Hospital for Children, 7 University of Greifswald,
8
University of Manchester, 9 University of Utah, Salt Lake City, UT,
10
Wake Forest University
3:15 PM
655. Gene Expression Profiling in Peripheral Blood
Mononuclear Cells Predicts Disease Flares in Children with
Polyarticular Juvenile Idiopathic Arthritis Who Have Achieved
Clinical Remission on Medication.
Nicholas Knowlton 2 , Mark Barton Frank 2 , Nicholas E. Armstrong 1 ,
Kaiyu Jiang 1 , Yanmin Chen 1 , Jeanette Osban 2 and James N.
Jarvis 1 , 1 Dept of Pediatrics, U of OK College of Medicine,
2
Oklahoma Medical Research Foundation
3:30 PM
656. Levels of beta2-Glycoprotein-I May Reflect a Protective
Effect on the Development of Heart Block in Fetuses Exposed
to Maternal Anti-Ro Antibodies.
Joanne H. Reed, Tom P. Gordon, Robert M. Clancy and Jill P.
Buyon, New York University School of Medicine
3:45 PM
657. Pathogenic Consequences of Mutations of NLRP12 Gene.
A New Cold-Induced Autoinflammatory Disease.
Silvia Borghini 2 , Sara Tassi 1 , Sabrina Chiesa 3 , Francesco Caroli 2 ,
Sonia Carta 1 , Roberta Caorsi 3 , Marco Di Duca 2 , Denise Lasigliè 3 ,
Alberto Martini 3 , Isabella Ceccherini 2 , Anna Rubartelli 1 and
Marco Gattorno 3 , 1 Institute for Cancer Research, Genoa, Italy,
2
Lab of Molecular Genetics, G. Gaslini Institute, Genoa, Italy,
3
Rheumatology Unit, G. Gaslini Institute, Genoa, Italy
Sidney J. Marcus Auditorium
Rheumatoid Arthritis - Clinical Aspects: Preclinical
RA and Early RA I
Moderators: Neal S. Birnbaum, MD; Pacific Rheumatology
Association; San Francisco, CA
Jonathan Kay, MD; UMass Memorial Medical Center; Worcester,
MA
2:30 PM
658. Application of the New ACR/EULAR Classification Criteria
for Rheumatoid Arthritis to At-Risk Populations May Identify
RA Prior to Clinical Presentation.
Jason R. Kolfenbach 5 , Lezlie Derber 5 , Kevin D. Deane 9 , Jan
Hughes-Austin 4 , Michael H. Weisman 3 , Jane Buckner 2 , Ted
R. Mikuls 11 , James R. O’Dell 8 , Peter K. Gregersen 6 , Richard
M. Keating 1 , Jill Norris 10 and V. Michael Holers 7 , 1O ak Park, IL,
2
Benaroya Research Institute at Virginia Mason, 3 Cedars-Sinai
Medical Center, Los Angeles, CA, 4 Department of Epidemiology,
Colorado School of Public Health, University of Colorado Denver,
5
Division of Rheumatology, University of Colorado at Denver,
Aurora, CO, 6 N Shore Univ Hosp Rsch Ctr, Manhasset, NY, 7 Univ
of Colorado School of Med, Aurora, CO, 8 University of Nebraska
Medical Center, Omaha, NE, 9 University of Colorado at Denver,
Aurora, CO, 10 University of Colorado Denver, Aurora, CO,
11
University of Nebraska Medical Center, Omaha, NE
2:45 PM
659. The Revised 2010 ACR/EULAR Diagnostic Criteria for
Rheumatoid Arthritis Identify Many More Patients Who Are
Eligible for Treatment and for Clinical Trials.
Vivian P. Bykerk 5 , Gilles Boire 2 , Boulos Haraoui 4 , Carol A.
Hitchon 8 , Ed C. Keystone 9 , J. Carter Thorne 6 , Diane S. Ferland 3 ,
Janet E. Pope 7 and CATCH Investogators 1 , 1 Canada, Canada,
2
CHUS - Sherbrooke University, Sherbrooke, QC, Canada, 3 Hopital
Maisonneuve Rosement, Montreal, LaSalle, QC, Canada, 4 Institut
de Rhumatologie, Montreal, QC, Canada, 5 Mt Sinai Hospital,
University of Toronto, Toronto, ON, Canada, 6 Southlake Regional
Health Care, Newmarket, ON, Canada, 7 St Joseph Health
Care London, London, ON, Canada, 8 University of Manitoba,
Winnipeg, MB, Canada, 9 University of Toronto, Toronto, ON,
Canada
3:00 PM
660. A Novel Diagnostic Marker for RA, Anti-MCV.
Rong W. Zablocki 1 , Annette Van der Helm – van Mil 3 , Tom
Huizinga 3 and Srinivas Rao 2 , 1 Cypress Bioscience Inc, San Diego,
CA, 2 Cypress Bioscience Inc, 3 Leiden University Medical Center,
The Netherlands
3:15 PM
661. Smoking Is a Predictor of Very Early Presentation with
Rheumatoid Arthritis.
David W. Sharpley 1 , Sarang Chitale 2 , Cristina Estrach 2 , Robert N.
Thompson 2 , Robert J. Moots 2 and Nicola J. Goodson 2 , 1Academic
Rheumatology Department, Aintree University Hospitals,
University of Liverpool, Liverpool, Merseyside, United Kingdom,
2
Academic Rheumatology Department, Aintree University
Hospitals, University of Liverpool
3:30 PM
662. Long-Term Remission in Daily Clinical Practice: Excellent 2
Year Results with Treatment To Target in Very Early Rheumatoid
Arthritis, Results of the DREAM Remission Induction Cohort.
Marloes Vermeer 5 , Ina H. Kuper 5 , Monique Hoekstra 1 , Hein
J. Bernelot Moens 6 , Marcel D. Posthumus 4 , Herman L. M.
Brus 3 , Piet L. C. M. van Riel 2 and Mart A. F. J. van de Laar 5 ,
1
Isala Klinieken, Zwolle, The Netherlands, 2 Radboud University
Nijmegen Medical Centre, Nijmegen, The Netherlands,
3
TweeSteden Ziekenhuis, Tilburg, The Netherlands, 4 University
Medical Center Groningen, Groningen, The Netherlands,
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2010 Program Book