B O O K - American College of Rheumatology

Session Overview:
Systemic sclerosis remains a major therapeutic challenge for
clinicians with significant potential morbidity and mortality.
Emerging therapies provide significant potential opportunities
for improved outcomes. Identifying which of these therapies
offers the greatest promise is of key importance.
Upon completion of this session, participants should be able to:
• explain the pathogenesis of interstitial lung disease
associated with scleroderma and outline the spectrum of new
therapeutic options in interstitial lung disease associated with
scleroderma
• identify and synthesize the emerging data on cardiovascular
complications including pulmonary hypertension to develop a
therapeutic approach
• describe the emerging role of stem cell therapy in scleroderma
and synthesize new clinical trial data on stem cell therapy
ACR Concurrent Abstract Sessions
4:30 - 6:00 PM
A402
Genetics, Genomics and Proteomics: SLE
Moderator: Betty P. Tsao, PhD; University of Californina-Los
Angeles School of Medicine; Los Angeles, CA
4:30 PM
2144. Exome Resequencing in a Densely Affected
Multigenerational SLE Pedigree.
Graham Wiley 2 , Chee Paul Lin 2 , Indra Adrianto 3 , Jennifer A.
Kelly 3 , Kathy L. Moser 2 , Kenneth M. Kaufman 3 , John B. Harley 4 ,
Courtney Gray-McGuire 2 and Patrick M. Gaffney 1 , 1 Oklahoma
Med Research Foundation, Oklahoma City, OK, 2 Oklahoma
Medical Research Foundation, Oklahoma City, OK, 3 Oklahoma
Medical Research Foundation, 4 Univ of OK Hlth Sci Ctr,
Oklahoma City, OK
4:45 PM
2145. Large-Scale Mapping of Systemic Lupus Erythematosus
(SLE) Variants across Different Ethnicities Reveals That the IRF5-
TNPO3 Region Is the Strongest Common Risk Factor.
Timothy J. Vyse 8 , Paula S. Ramos 3 , Kenneth M. Kaufman 2 ,
Jennifer A. Kelly 2 , Caroline Gallant 7 , Angelica Delgado 6 , Sharon
A. Chung 10 , Lindsey A. Criswell 12 , Robert P. Kimberly 4 , Mary E.
Comeau 3 , Adrienne H. Williams 3 , Laurie P. Russell 3 , Chaim O.
Jacob 9 , Betty P. Tsao 11 , Marta E. Alarcon-Riquelme 5 , Kathy L.
Moser 1 , Patrick M. Gaffney 1 , John B. Harley 13 , Carl D. Langefeld 3
and SLEGEN Consortium, 1 Arthritis and Immunology Program,
Oklahoma Medical Research Foundation, Oklahoma City,
OK, 2 Arthritis and Immunology Program, Oklahoma Medical
Research Foundation, 3 Dept Biostatistical Sciences, Wake
Forest University Health Sciences, 4 Dept Medicine, University
of Alabama at Birmingham, Birmingham, AL, 5 Dept of Genetics
and Pathology, Uppsala University, Uppsala, Sweden, 6 Dept of
Genetics and Pathology, Uppsala University, 7 Dept of Genetics
and Pathology, Uppsala University, Sweden, 8 Faculty of Medicine,
Imperial College, London, UK, 9 Keck School of Medicine,
University of Southern California, Los Angeles, CA, 10 Rosalind
Russell Medical Research Center for Arthritis, University of
California, San Francisco, San Francisco, CA, 11 UCLA School of
Medicine, Los Angeles, CA, 12 UCSF-Box 0500, San Francisco, CA,
13
Univ of OK Hlth Sci Ctr, Oklahoma City, OK
5:00 PM
2146. Targeted Resequencing in Systemic Lupus Erythematosus
Genetic Risk Loci: Initial Results from the REVEAL
(Resequencing Variants Enhancing Autoimmunity and Lupus)
Resource.
Patrick M. Gaffney 1 , Graham Wiley 2 , Jennifer A. Kelly 2 , Kenneth
M. Kaufman 2 , John B. Harley 3 , Ekta Rai 4 and Edward K.
Wakeland 4 , 1 Oklahoma Medical Research Foundation, Oklahoma
City, OK, 2 Oklahoma Medical Research Foundation, Oklahoma
City, OK, 3 Univ of OK Hlth Sci Ctr, Oklahoma City, OK, 4 University
of Texas Southwestern Medical Center, Dallas, TX
5:15 PM
2147. Identification of a Novel Systemic Lupus Erythematosus
Susceptibility Locus at 11p13 near CD44 in a Multi-Ethnic Study.
Christopher J. Lessard 3 , Indra Adrianto 1 , Jennifer A. Kelly 1 ,
Kenneth M. Kaufman 1 , Marta E. Alarcon-Riquelme for the
BIOLUPUS Network 2 , Juan-Manuel Anaya 4 , Sang-Cheol Bae 10 ,
Elizabeth E. Brown for PROFILE 6 , Lindsey A. Criswell 14 , Jeffrey C.
Edberg 8 , Barry I. Freedman 7 , Chaim O. Jacob 9 , Judith A. James 1 ,
Robert P. Kimberly 8 , Javier Martin 13 , Joan T. Merrill 5 , Timothy
B. Niewold 16 , Bernardo A. Pons-Estel 15 , Betty P. Tsao 12 , Timothy
J. Vyse 11 , Courtney G. Montgomery 1 , John B. Harley 17 , R. Hal
Scofield 1 , Patrick M. Gaffney 1 and Kathy L. Moser 1 , 1 Arthritis and
Immunology Research Program, Oklahoma Medical Research
Foundation, 2 Arthritis and Immunology Research Program,
Oklahoma Medical Research Foundation and Center for
Genomics and Oncological Research (GENyO), Granada, Spain,
3
Arthritis and Immunology Research Program, Oklahoma Medical
Research Foundation and Department of Pathology, University
of Oklahoma Health Sciences Center, Oklahoma City, OK, 4 Center
for Autoimmune Diseases Research (CREA), Universidad del
Rosario, Bogota, Columbia, 5 Clinical Pharmacology, Oklahoma
Medical Research Foundation, 6 Department of Epidemiology,
University of Alabama at Birmingham, Birmingham, AL,
7
Department of Internal Medicine, Wake Forest University
Health Sciences, Winston-Salem, NC, 8 Department of Medicine,
University of Alabama at Birmingham, Birmingham, AL,
9
Department of Medicine, University of Southern California, Los
Angeles, CA, 10 Department of Rheumatology, Hanyang University
Hospital for Rheumatic Diseases, Seoul, Korea, 11 Division of
Medicine, Imperial College of London, London, UK, 12 Division of
Rheumatology, Department of Medicine, University of California
Los Angeles, Los Angeles, CA, 13 Instituto de Parasitologia y
Biomedicina Lopez-Neyra, Consejo Superior de Investigaciones
Cientificas (CSIC), Granada, Spain, 14 Rosalind Russell Medical
Research Center for Arthritis, University of California San
Francisco, 15 Sanatorio Parque, Rosario, Argentina, 16 Section
of Rheumatology and Gwen Knapp Center for Lupus and
Immunology Research, University of Chicago, 17 US Department
of Veterans Affairs Medical Center, Department of Medicine,
University of Oklahoma Health Sciences Center, and Cincinnati
Children’s Hospital Medical Center
5:30 PM
2148. Study of Systemic Lupus Erythematosus Susceptibility
Genes in a Hispanic Population: Identification of Six New
Candidate Susceptibility Loci.
Elena Sanchez-Rodriguez 1 , Kenneth M. Kaufman 3 , Jennifer
A. Kelly 1 , Adrienne H. Williams 11 , Paula S. Ramos 11 , Astrid
Rasmussen 1 , Chaim O. Jacob 9 , Patrick M. Gaffney 1 , Kathy
2010 Program Book 123
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