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B O O K - American College of Rheumatology

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REF 25th Anniversary Celebration<br />

2:45 - 3:30 PM<br />

Halls A1 & A2<br />

REF Philanthropy Showcase (Booth#1325)<br />

ACR/ARHP Workshops<br />

4:00 - 6:00 PM<br />

Admission to each Workshop requires a separate registration<br />

and ticket. To verify which session you registered for, check to<br />

make sure the registration code on your ticket matches the code<br />

listed below in parentheses.<br />

B203<br />

Musculoskeletal Ultrasound (213)<br />

Speaker: Eugene Y. Kissin, MD; Boston University; Boston, MA<br />

Upon completion <strong>of</strong> this session, participants should be able to:<br />

• describe the indications for ultrasound in rheumatic diseases<br />

• discuss the techniques <strong>of</strong> ultrasonography<br />

• identify normal and abnormal anatomical structures by<br />

ultrasound imaging<br />

B204<br />

Pediatric Musculoskeletal Upper/Lower Examinations<br />

(214)<br />

Speaker: Christine W. Kennedy, MSN, RN, CPNP; Emory<br />

Children’s Center; Decatur, GA<br />

Upon completion <strong>of</strong> this session, participants should be able to:<br />

• discuss principles <strong>of</strong> pediatric musculoskeletal physical<br />

examination<br />

• detect and describe normal and abnormal pediatric<br />

musculoskeletal physical examination findings<br />

• demonstrate rheumatologic upper and lower musculoskeletal<br />

examinations for pediatric patients using patient volunteers<br />

B202<br />

Renal Histopathology in Systemic Lupus<br />

Erythematosus and Vasculitis (215)<br />

Speaker: Megan Troxell, MD; Oregon Health & Science<br />

University; Portland, OR<br />

Upon completion <strong>of</strong> this session, participants should be able to:<br />

• identify the pathologic changes that occur in lupus nephritis<br />

• discuss the pathologic basis for the classification <strong>of</strong> lupus<br />

nephritis and how it relates to clinical management<br />

• describe the histological changes in the kidneys <strong>of</strong> patients<br />

with vasculitis<br />

ARHP Concurrent Session<br />

4:00 - 6:00 PM<br />

B201<br />

You’ve Got the Power: How to Use and Teach<br />

Statistical Power for Studies and Grants R<br />

Moderator: Annette M. Oeser, BS, CCRP; Vanderbilt University<br />

Medical Center; Nashville, TN<br />

Speakers: Alyssa B. Dufour, MA; Hebrew Senior Life; Boston, MA<br />

Marian T. Hannan, DSc, MPH; Hebrew Senior Life and Harvard<br />

Medical School; Boston, MA<br />

Robert R. McLean, DSc, MPH; Hebrew Senior Life; Boston, MA<br />

Session Overview:<br />

Understanding the concept <strong>of</strong> statistical power is critical not only<br />

when designing a research study, but also when interpreting<br />

the results <strong>of</strong> a study. Often researchers have only rudimentary<br />

knowledge <strong>of</strong> calculating and interpreting power, and rely solely<br />

on statisticians to contend with power issues. The web-based<br />

activities covered in this session will allow participants to<br />

practice conducting power calculations with freely available<br />

power calculators.<br />

Upon completion <strong>of</strong> this session, participants should be able to:<br />

• describe the underlying concepts <strong>of</strong> statistical power and why<br />

it is important for research studies<br />

• utilize the methods <strong>of</strong> calculating statistical power, sample<br />

size, and minimal detectable difference when appropriate<br />

• effectively interpret and communicate results <strong>of</strong> statistical<br />

power calculations as both a rheumatology researcher and a<br />

consumer <strong>of</strong> the research literature in study design, grantwriting,<br />

IRB applications<br />

• utilize methods for teaching statistical power to students,<br />

including an interactive experience <strong>of</strong> conducting power<br />

analyses for case studies using web-based calculators<br />

ACR Basic Science Symposium<br />

4:30 - 6:00 PM<br />

A411<br />

The Revolution <strong>of</strong> Epigenetics in Autoimmunity R<br />

Moderator: Jennifer H. Anolik, MD, PhD; University <strong>of</strong> Rochester;<br />

Rochester, NY<br />

4:30 PM<br />

The Relevance <strong>of</strong> Epigenetics for <strong>Rheumatology</strong><br />

Bruce C. Richardson, MD, PhD; University <strong>of</strong> Michigan; Ann<br />

Arbor, MI<br />

5:00 PM<br />

Epigenetic Influences in Systemic Lupus Erythematosus<br />

Revealed by Twin Studies<br />

Esteban Ballestar, PhD; Bellvitge Biomedical Research Institute;<br />

L’Hospitalet de Llobregat, Barcelona, Spain<br />

5:30 PM<br />

Epigenetic Influences in Rheumatoid Arthritis<br />

Steffen Gay, MD; University Hospital Zurich Switzerland; Zurich,<br />

Switzerland<br />

Session Overview:<br />

The term epigenetics refers to changes in gene expression<br />

caused by mechanisms other than changes in the underlying<br />

DNA sequence, examples include chromatin structure, histone<br />

modifications, DNA methylation, and microRNA regulation.<br />

It has become increasingly clear that epigenetics provides a<br />

critical alternative mechanism for modulating gene function<br />

to those arising from genetic changes and may explain the<br />

variable penetrance <strong>of</strong> autoimmune phenotypes. Epigenetic<br />

mechanisms are essential for normal development and function<br />

<strong>of</strong> the immune system. Similarly, a failure to maintain epigenetic<br />

monday<br />

2010 Program Book 47

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