B O O K - American College of Rheumatology

ACR/ARHP Poster Session C
1719. Loss of Integrin alpha2beta1 Suppresses Joint Inflammation
and Cartilage Destruction in Mouse Models of Rheumatoid
Arthritis. Marvin A. Peters 4 , Doreen Wendholt 6 , Simon
Strietholt 6 , Svetlana Frank 6 , Adelheid Korb 5 , Leo A. B. Joosten 2 ,
Wim B. Van Den Berg 8 , George Kollias 7 , Elena Neumann 3 , Beate
Eckes 1 , Ulf Muller-Ladner 9 and Thomas Pap 10 , 1 Department of
Dermatology, University of Cologne, 2 Department of General
Internal Medicine, Radboud University Nijmegen Medical
Centre, 3 Department of Internal Medicine and Rheumatology,
Justus-Liebig-University Giessen, Kerckhoff Clinic, Bad Nauheim,
Germany, 4 Department of Internal Medicine and Rheumatology,
Justus-Liebig-University Giessen, Kerckhoff Clinic; Institute
of Experimental Musculoskeletal Medicine, University of
Muenster, Bad Nauheim, Germany, 5 Department of Internal
Medicine D, University of Muenster, 6 Institute of Experimental
Musculoskeletal Medicine, University of Muenster, Muenster,
Germany, 7 Institute of Immunology, Biomedical Sciences
Research Center, 8 Radboud Univ Nijmegen Med Cntr, Nijmegen,
The Netherlands, 9 Univ.Giessen/Kerckhoff-Clinic, Bad Nauheim,
Germany, 10 University Hospital Münster, Münster, Germany.
1720. Lung Inflammation and Pulmonary Function Alterations in
Collagen-Induced Arthritis and in the Absence of Interferongamma
Signaling. Evelien Schurgers 1 , Freya Mertens 2 , Jeroen
Vanoirbeek 3 , Tania Mitera 2 , Stéphanie Put 2 , Benoit Nemery 3 and
Patrick Matthys 2 , 1 Laboratory of Immunobiology, Rega Institute,
Katholieke Universiteit Leuven, Leuven, Belgium, 2 Laboratory of
Immunobiology, Rega Institute, Katholieke Universiteit Leuven,
Leuven, Belgium, 3 Research Unit of Lung Toxicology (Laboratory
of Pneumology), Katholieke Universiteit Leuven, Leuven,
Belgium.
1721. Macrophage Migration Inhibitory Factor Plays an Important
Role in Inflammatory Arthritis. Mohammad A. Amin 2 , Jeffrey
H. Ruth 2 , Bradley J. Rabquer 2 , Phillip L. Campbell 2 , Solhee Lee 2 ,
John R. David 1 and Alisa E. Koch 3 , 1 Harvard School of Public
Health, 2 University of Michigan, 3 VA Medical Service and
University of Michigan Medical School, Ann Arbor, MI.
1722. Matrix Components Influence the Aggressive Behavior of
Rheumatoid Arthritis Synovial Fibroblasts. Stephanie Lefevre 2 ,
Birgit Zimmermann 3 , Matthias Geyer 3 , Angela Lehr 5 , Henning
Stürz 4 , Jürgen Steinmeyer 1 , Stefan Rehart 5 , Ulf Müller-Ladner 3
and Elena Neumann 3 , 1 Dept Experimental Orthopedics,
Justus-Liebig-University Giessen, 2 Dept Internal Medicine and
Rheumatology, Justus-Liebig University Giessen, Bad Nauheim,
Germany, 3 Dept Internal Medicine and Rheumatology, Justus-
Liebig University Giessen, 4 Dept Orthopedics and Orthopedic
Surgery, Justus-Liebig-University Giessen, 5 Dept Orthopedics
and Trauma Surgery, Markus-Hospital, Frankfurt.
1723. Monocytes Are Required for Progression but Not for Initiation
of Arthritis in Mouse Model of Autoantibody-Mediated
Arthritis. Alexander Misharin 1 , Evan Weber 1 and Harris R.
Perlman 2 , 1 Division of Rheumatology, Northwestern University,
Chicago, IL, 2 Northwestern University, Chicago, IL.
1724. Overexpression of RORγt Attenuated Collagen Induced
Arthritis (CIA). Zhaojin Yao 2 , Yuya Kondo 2 , Masahiro Tahara 2 ,
Satoru Takahashi 1 , Isao Matsumoto 2 and Takayuki Sumida 3 ,
1
Department of Anatomy and Embryology, Biomolecular, and
Integrated Medical Sciences, Graduate School of Comprehensive
Human Sciences, University of Tsukuba, 2 Division of Clinical
Immunology, Major of Advanced Biochemical Applications,
Graduate School of Comprehensive Human Science, University
of Tsukuba, Ibaraki, Japan, 3 Univ of Tsukuba/Inst Clin Med,
Tsukuba City, Japan.
1725. Paradoxical Decrease in Collagen Induced Arthritis Severity in
Gadd45β Deficient Mice. Yubin Luo 2 , David L. Boyle 1 and Gary S.
Firestein 1 , 1 UCSD School of Medicine, La Jolla, CA, 2 UCSD School
of Medicine.
1726. Protection from Collagen-Induced Arthritis in a CX3CR1-
Deficient Mouse Strain. Grainne Murphy 1 , Arun Kumar 2 , Fergus
Shanahan 1 , Sinead Harney 1 , Michael Molloy 1 and Noel Caplice 2 ,
1
Cork University Hospital, Cork, Ireland, 2 University College Cork,
Cork, Ireland.
1727. Role of the Central Nervous System (CNS) in Peripheral
Inflammation: Sympathetic Innervation of the Spleen
Regulates Inflammatory Arthritis. David L. Boyle 1 , Meghan
Edgar 2 , Linda Sorkin 2 and Gary S. Firestein 1 , 1 UCSD School of
Medicine, La Jolla, CA, 2 UCSD School of Medicine.
1728. SapC-DOPS Agents in Imaging Arthritis. Sherry Thornton 1 ,
Malinda Pinkerton 2 , Monica DeLay 2 , Tristan Bourdeau 2 , Rachel
Mason 2 , Zhengtao Chu 2 , Matthew Flick 2 and Xiaoyang Qi 1 ,
1
Cincinnati Children’s Research Foundation, Cincinnati, OH,
2
Cincinnati Children’s Research Foundation.
1729. Systemic, Lentiviral Gene Delivery of the Stress Protein
BiP (Binding Immunoglobulin Protein) Improves Clinical,
Histological and Immunological Parameters of Collagen-
Induced Arthritis Via Suppression of IL-17. Adrian M. Shields 2 ,
Paul H. Wooley 3 , Rana Alyahya 2 , Gabriel S. Panayi 1 , Stephen J.
Thompson 2 and Valerie M. Corrigall 2 , 1 King’s College London,
London, United Kingdom, 2 King’s College London, 3 Via Christi
Reg Medical Ctr, Wichita, KS.
1730. Targets of Innate and Adaptive Immunity in a Humanized
Arthritis Model: Research Value of the RA Synovium SCID
Mouse Model. Marije I. Koenders 3 , Shahla Abdollahi-Roodsaz 4 ,
Renoud J. Marijnissen 4 , Franco E. Di Padova 2 , John Dulos 1 ,
Annemieke M. H. Boots 1 and Wim B. van den Berg 4 , 1 MSD,
Oss, The Netherlands, 2 Novartis Pharma AG, Switzerland,
3
Radboud University Nijmegen Medical Centre, Nijmegen, The
Netherlands, 4 Radboud University Nijmegen Medical Centre,
The Netherlands.
1731. The Role for TIM-2 in Collagen-Induced Arthritis. Toshio
Kawamoto 2 , Hisaya Akiba 1 , Yoshiyuki Abe 2 , Shinji Morimoto 2 ,
Ken Yamaji 2 , Naoto Tamura 2 and Yoshinari Takasaki 2 ,
1
Department of Immunology, Juntendo University School of
Medicine, 2 Department of Rheumatology, Juntendo University
School of Medicine.
1732. The TNF-Ligand APRIL Can Control CIA by Regulating Antibody-
Production and Stimulating Anti-Inflammatory IL-10 Producing
B Cells. Leticia Fernandez 5 , Cecilia Rocha 5 , Carla Carvalho-Pinto 6 ,
Jan Paul Medema 2 , Bernard G. Combe 3 , Dominique Baeten 1 ,
Jacques Morel 4 and Michael Hahne 5 , 1 Academic Med Ctr/
Univ of Amsterdam, Amsterdam, The Netherlands, 2 Academic
Medical Center, University of Amsterdam, 3 Hopital Lapeyronie,
Montpellier, France, 4 Hopital Lapeyronie, 5 Institut de Génétique
Moléculaire de Montpellier, 6 Universidade Federal Fluminense/
UFF, Niteroi.
1733. Towards Personalized Arthritis Gene Therapy: Screening of
Computationally-Designed Promoters in an In Vivo Mouse
Model and in Human Synovial Fibroblasts. Fons A. J. van de
Loo, Eline Vermeij, Onno J. Arntz, Miranda B. Bennink, Jeroen
Geurts and Wim B. van den Berg, Department of Rheumatology,
Radboud University Nijmegen Medial Centre, Nijmegen, The
Netherlands.
2010 Program Book 253