B O O K - American College of Rheumatology

thursday
9:00 AM
2214. Genome-Wide Association Study of Systemic Sclerosis
Clinical Features Identifies New Disease Risk Variants.
Olga Gorlova 16 , Jose-Ezequiel Martin 15 , Blanca Rueda 15 , Bobby P.
C. Koeleman 19 , Maria Teruel 15 , Lina-Marcela Diaz-Gallo 15 , Jasper
C. Broen 12 , Madelon C. Vonk 17 , Carmen P. Simeon 14 , Behrooz Z.
Alizadeh 8 , Marieke J. H. Coenen 8 , Alexandre E. Voskuyl 9 , Annemie
J. Schuerwegh 8 , Piet L. C. M . van Riel 8 , Ruben van ‘t Slot 8 , Annet
Italiaander 8 , Roel A. Ophoff 8 , Nico Hunzelmann 3 , Norberto
Ortego-Centeno 6 , Miguel A. González-Gay 6 , María F González-
Escribano 6 , Paolo Airo 4 , Jaap van Laar 1 , Jane Worthington 1 ,
Roger Hesselstrand 7 , Vanessa Smith 2 , Filip de Keyser 2 , Fredric
Houssiau 2 , Meng May Chee 1 , Rajan Madhok 1 , Paul Shiels 1 , Rene
Westhovens 2 , Alexander Kreuter 3 , Hans Kiener 10 , Elfride de
Baere 2 , Torsten Witte 3 , Leonid Padykov 7 , Lars Klareskog 7 , Rafaella
Scorza 4 , Benedicte A. Lie 5 , Anna-Maria Hoffmann-Vold 3 , Patricia
Carreira 6 , John Varga, Monique Hinchcliff, Annette T. Lee, Pravitt
Gourh, Christopher I. Amos, Gabriella Riemekasten 11 , Ariane
Herrick 20 , Lorenzo Beretta 21 , Peter K. Gregersen 13 , Sandeep
Agarwal 18 , Shervin Assassi 18 , Filemon K. Tan 18 , Frank C. Arnett 18 ,
Timothy R. D. J. Radstake 17 , Maureen D. Mayes 18 and Javier
Martin 15 , 1 United Kingdom, 2 Belgium, 3 Germany, 4 Italy, 5 Norway,
6
Spain, 7 Sweden, 8 The Netherlands, 9 The The Netherlands,
10
Austria, 11 Charité University Hospital, Germany, 12 Department
of Rheumatology, Radboud University Nijmegen Medical Center,
The Netherlands, 13 Feinstein Institute of Medical Research,
14
Hospital Valle de Hebron, Spain, 15 Instituto de Parasitologia
y Biomedicina Lopez-Neyra, Spain, 16 MD Anderson, 17 Radboud
University Nijmegen Medical Center, The Netherlands, 18 The
University of Texas Health Science Center–Houston, 19 University
Medical Center Utrecht, The Netherlands, 20 University of
Manchester, Manchester Academic Health Science Centre,
United Kingdom, 21 University of Milan, Italy
9:15 AM
2215. Genetic Markers of Rheumatoid Arthritis Susceptibility
in Anti-Citrullinated Peptide Antibody Negative and Shared
Epitope Negative Patients.
Sebastien Viatte 1 , Darren Plant 2 , John Bowes 2 , Anne Barton 2 and
Jane Worthington 1 , 1 Arthritis Research UK Epidemiology Unit,
The University of Manchester, Manchester, United Kingdom,
2
Arthritis Research UK Epidemiology Unit, The University of
Manchester
9:30 AM
2216. A Signature of Aberrant Responsiveness of the Peripheral
Immune System Predicts the 6-Month Risk of Infections in
Rheumatoid Arthritis.
Megan L. Krause, John M. Davis III, Michael A. Strausbauch,
Cynthia S. Crowson, Terry M. Therneau, Eric L. Matteson, Keith L.
Knutson and Sherine E. Gabriel, Mayo Clinic, Rochester, MN
9:45 AM
2217. Homozygous 3.2kb Deletion in LEPREL1 (P3H2) Intron
1 Reduces Cytokine Production and Protects from Multiple
Inflammatory Diseases.
Yohei Kirino 14 , Michael J. Ombrello 15 , Ahmet Gul 11 , Kai Wang 1 ,
Akira Meguro 7 , Barbara Yang 14 , Massimo Gadina 14 , Fulya Cosan 11 ,
Neslihan Abaci 3 , Katherine Siminovitch 9 , Peter K. Gregersen 12 ,
Phaedon Kaklamanis 8 , Young-Hun Cho 10 , Dongsik Bang 2 , Hongwei
Sun 14 , Christopher Amos 16 , Massa Hama 4 , Mitsuhiro Takeno 4 ,
Nobuhisa Mizuki 7 , Hidetoshi Inoko 5 , Shigeaki Ohno6, Yoshiaki
Ishigatsubo 17 , Hakon Hakonarson 1 , Daniel L. Kastner 13 and
Elaine Remmers 14 , 1 Center for Applied Genomics, The Children’s
Hospital of Philadelphia, 2 Department of Dermatology, Yonsei
University College of Medicine, 3 Department of Genetics,
Institute for Experimental Medicine, 4 Department of Internal
Medicine and Clinical Immunology, Yokohama City University
Graduate School of Medicine, 5 Department of Molecular Life
Science, Division of Molecular Medical Science and Molecular
Medicine, Tokai University School of Medicine, 6 Department
of Ocular Inflammation and Immunology, Hokkaido University
Graduate School of Medicine, 7 Department of Ophthalmology
and Visual Science, Yokohama City University Graduate School
of Medicine, 8 Department of Rheumatology, Athens Medical
Center, Athens, Greece, 9 Departments of Medicine, Immunology
and Molecular Genetics, Department of Medicine, University of
Toronto, Mount Sinai Hospital and University Health Network,
10
Graduate School of Medical Science and Engineering, KAIST,
11
Istanbul Faculty of Medicine, Department of Internal Medicine,
Division of Rheumatology, Istanbul University, 12 N Shore Univ
Hosp Rsch Ctr, Manhasset, NY, 13 NIAMS, NIH, Bethesda, MD,
14
NIAMS/National Institute of Health, 15 NIAMS/National Institute
of Health, Bethesda, MD, 16 University of Texas M. D. Anderson
Cancer Center, 17 Yokohama City Grad Sch of Med, Yokohama,
Japan
10:00 AM
2218. Association of IL2RB Polymorphisms with Erosive Disease
in ACPA Positive Early Rheumatoid Arthritis (RA): Results from
the ESPOIR Cohort.
Adeline Ruyssen-Witrand 3 , Delphine Nigon 4 , Alain G . Cantagrel 5 ,
Cédric Lukas 7 , Jacques Morel 7 , Jean Sibilia 6 , Anne Cambon-
Thomsen 1 and Arnaud L. Constantin 2 , 1 INSERM, U558,
Toulouse, France, 2 Purpan University Hospital, Toulouse, France,
3
Rheumatology Center, Purpan Teaching Hospital, Toulouse,
Toulouse, France, 4 Rheumatology Center, Purpan Teaching
Hospital, Toulouse, France, 5 Rheumatology Center, Purpan
Teaching Hospital, Toulouse, University Paul Sabatier, Toulouse,
France, 6 Rheumatology Department, Hautepierre Teaching
Hospital, Strasbourg, France, 7 Rheumatology Department,
Lapeyronie Teaching Hospital, Montpellier, France
10:15 AM
2219. Discovery and Replication of JIA Predisposition Genes
by Genome-Wide Association and Validation of Candidates in
Fibroblast-Like Synoviocytes.
Terri H. Finkel 9 , Haitao Zhang 1 , Benedicte A. Lie 10 , Edward M.
Behrens 3 , Mara L. Becker 2 , Carol Wise 6 , Marilynn Punaro 7 ,
Emma Reuschel 8 , Debra Shivers 8 , Berit Flatø 4 , Øystein Førre 4 ,
Jane Munro 11 , Justine Ellis 11 and Hakon Hakonarson 5 , 1 Center
for Applied Genomics, The Children’s Hospital of Philadelphia,
2
Children’s Mercy Hospital, Kansas City, MO, 3 Childrens Hospital
of Phil, Philadelphia, PA, 4 Department of Rheumatology,
Oslo University Hospital, Rikshospitalet, Norway, 5 Division of
Genetics, The Children’s Hospital of Philadelphia, University of
Pennsylvania, 6 Division of Medical Genetics, Texas Scottish Rite
Hospital for Children, 7 Division of Rheumatology, Texas Scottish
Rite Hospital for Children, 8 Division of Rheumatology, The
Children’s Hospital of Philadelphia Research Institute, 9 Division
of Rheumatology, The Children’s Hospital of Philadelphia,
University of Pennsylvania, Philadelphia, PA, 10 Institute of
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2010 Program Book