NIS - libdoc.who.int - World Health Organization

WHO monographs on medicinal plants commonly used in the Newly Independent States (NIS)
tric administration (0.6 mg). The results demonstrated that 20–30% of the
total fraction, 40–81% of the trimeric procyanidins and 16–42% of the
oligomeric procyanidins were absorbed within 1–7 hours after administration.
After 7 hours, 0.6% of the radioactivity of the total fraction was
eliminated by expiration and 6.4% was eliminated in the urine. Daily intragastric
administration of 0.6 mg of a radiolabelled oligomeric procyanidin
fraction to mice for 7 days led to an accumulation of radioactivity
that was 2–3 times that in mice given a single dose (83).
Contraindications
None (84).
Warnings
Accurate diagnosis of stage II congestive heart failure should be obtained
prior to use of Folium cum Flore Crataegi. Consult a physician
if symptoms worsen, remain unchanged for longer than 6 weeks, or if
water accumulates in the legs. Medical attention is absolutely necessary
if pain occurs in the region of the heart, spreading out to the arms, upper
abdomen or neck area, or in cases of respiratory distress (e.g. dyspnoea)
(84).
Precautions
Drug interactions
None (84).
Drug and laboratory test interactions
No effects in laboratory tests (i.e. serum levels of sodium chloride, potassium
chloride, calcium chloride, serum glutamate oxaloacetate transaminase,
serum glutamate pyruvate transaminase, γ-glutamyl transpeptidase,
total bilirubin, cholesterol and creatinin, and blood glucose levels) were
observed (34).
Carcinogenesis, mutagenesis, impairment of fertility
A standardized extract of Folium cum Flore Crataegi (containing
18.75% oligomeric procyanidins) was not mutagenic or clastogenic in
the Salmonella/microsome assay, mouse lymphoma test, cytogenetic
analysis in cultured human lymphocytes or in the mouse bone marrow
micronucleus test (82). A fluidextract was moderately active in the Salmonella/microsome
assay in S. typhimurium strain TA98 only after
104