NIS - libdoc.who.int - World Health Organization

WHO monographs on medicinal plants commonly used in the Newly Independent States (NIS)
Paediatric use
The safety and effectiveness of the drug in children have not been established.
Other precautions
No information available about drug and laboratory test interactions.
Adverse reactions
No adverse reactions have been associated with the drug when used within
the recommended dosage and treatment period.
Prolonged use (>6 weeks) of excessive doses (>50 g/day) can lead to
pseudoaldosteronism, which includes potassium depletion, sodium retention,
oedema, hypertension, and weight gain (9, 57, 58). In rare cases,
myoglobinuria and myopathy can occur (59).
Posology
Unless otherwise prescribed, average daily dose of crude plant material,
5–15 g, corresponding to 200–800 mg of glycyrrhizin. Doses of other
preparations should be calculated accordingly (29). Radix Glycyrrhizae
should not be used for longer than 4–6 weeks without medical advice.
References
1. African pharmacopoeia, Vol. 1, 1st ed. Lagos, Organization of African Unity,
Scientific Technical & Research Commission, 1985:131–134.
2. European pharmacopoeia, 2nd ed. Strasbourg, Council of Europe, 1995.
3. British pharmacopoeia. London, Her Majesty’s Stationery Office, 1988.
4. Deutsches Arzneibuch 1996. Stuttgart, Deutscher Apotheker Verlag, 1996.
5. Pharmacopoeia Helvetica VII. Berne, Département fédéral de l’intérieur, 1994.
6. Pharmacopoeia of the People’s Republic of China (English ed.). Guangzhou,
Guangdong Science and Technology Press, 1992.
7. The pharmacopoeia of Japan XII. Tokyo, The Society of Japanese Pharmacopoeia,
1991.
8. Farmakope Indonesia, 4th ed. Jakarta, Departemen Kesehatan, Republik Indonesia,
1995.
9. Bradley PR, ed. British herbal compendium, Vol. 1. Bournemouth, British
Herbal Medicine Association, 1992:145–148.
10. Kapoor LD. Handbook of Ayurvedic medicinal plants. Boca Raton, FL,
CRC Press, 1990:194–195.
11. The Indian pharmaceutical codex. Vol. I. Indigenous drugs. New Delhi,
Council of Scientific & Industrial Research, 1953:112–113.
12. Ghazanfar SA. Handbook of Arabian medicinal plants. Boca Raton, FL,
CRC Press, 1994:110–111.
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