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Folium cum Flore Crataegi
metabolic activation. The mutagenic activity appeared to be due to the
quercetin content of the extract; however, the amount of quercetin ingested
in a normal daily diet is higher than would be obtained from the
extract (85). Intragastric administration of up to 1.6 g/kg body weight
had no effect on the fertility of female and male rats or the F 1
generation
(86).
Pregnancy: teratogenic effects
Intragastric administration of up to 1.6 g/kg body weight of a standardized
extract of Folium cum Flore Crataegi to rats and rabbits was not
teratogenic (86).
Pregnancy: non-teratogenic effects
No peri- or postnatal toxicity was observed in rats treated intragastrically
with a standardized extract of Folium cum Flore Crataegi (1.6 g/kg body
weight) (86).
Other precautions
No information available on general precautions or precautions concerning
nursing mothers or paediatric use. Therefore, Folium cum Flore Crataegi
should not be administered during lactation or to children without
medical supervision.
Adverse reactions
None (84).
Dosage forms
Crude drug for infusion and hydroalcoholic extracts (35). Store in a wellclosed
container, protected from light and moisture (1).
Posology
(Unless otherwise indicated)
Daily dosage: 160–900 mg dried 45% ethanol or 70% methanol extract
(drug:extract ratio 4–7:1) standardized to contain 18.75% oligomeric procyanidins
(calculated as epi-catechin) or 2.2% flavonoids (calculated as
hyperoside), respectively (26–29, 31–34, 84); 1.0–1.5 g comminuted crude
drug as an infusion 3–4 times daily (35). Therapeutic effects may require
4–6 weeks of continuous therapy (84).
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