NIS - libdoc.who.int - World Health Organization

WHO monographs on medicinal plants commonly used in the Newly Independent States (NIS)
of the plant to the feed of rats, at a concentration of 25–50% w/w, suppressed
the induction of estrus (43). However, oral administration of an
extract of the leaves to rats did not alter the time of first mating, fertility
or litter size (44). The effect of a 96% ethanol extract (200 mg/kg bw per
day, intraperitoneally, for 20 days) and an 80% ethanol extract (300 mg/
kg bw per day, orally, for 30 days) of the flowers on the spermatogenesis
of Swiss mice was assessed by examining morphological characteristics
with light and electron microscopes. Neither dose caused a significant difference
in body weight gain or in the weight of the testes and seminal
vesicles. The alterations observed were exfoliation of immature germ
cells, germ cell necrosis, and seminiferous tubule vacuolization. Animals
treated with the extracts had an increased number of metaphases in the
germ epithelium that might be due to cytotoxic substances or substances
stimulating cell proliferation (45).
Pregnancy: Non-teratogenic effects
See Contraindications.
Nursing mothers
Due to the lack of safety data the crude drug should not be used by breastfeeding
mothers.
Paediatric use
Due to the lack of safety data the crude drug should not be used in children
under the age of 12 years.
Other precautions
No information was found.
Dosage forms
Crude drug, extracts, fluidextract, infusions, succus (pressed juice from
fresh herb) and tinctures.
Posology
(Unless otherwise indicated) (12)
Internal: 4.5 g of cut herb (flowering top) per day, or 3.0 g cut flowers for
teas (infusions) and other Galenical preparations; pressed juice of freshly
harvested herb.
Infusion: 1–2 g in 150 ml boiled water for 10–15 minutes, three times daily
between meals.
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